دورية أكاديمية
أعرض في EDS

A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014-2018).

التفاصيل البيبلوغرافية
العنوان: A prospective, multicentre, cohort study to assess the incidence of dengue illness in households from selected communities in Brazil (2014-2018).
المؤلفون: de Aguiar DF; Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos/Fiocruz, Avenida Brasil 4.365, Manguinhos, Rio de Janeiro - RJ, 21.040-900, Brazil., de Barros ENC; GSK, Estrada dos Bandeirantes, 8464, Jacarepaguá, Rio de Janeiro - RJ, 22775-610, Brazil., Ribeiro GS; Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, Avenida Waldemar Falcão, 121, Candeal, Salvador - BA, 40296-710, Brazil; Faculdade de Medicina, Universidade Federal da Bahia, Avenida Adhemar de Barros, s/nº - Ondina, Salvador - BA, 40170-110, Brazil., Brasil P; Instituto Nacional de Infectologia Evandro Chagas (INI/Fiocruz), Avenida Brasil 4.365, Manguinhos, Rio de Janeiro - RJ, 21.040-900, Brazil., Mourao MPG; Universidade do Estado do Amazonas, Avenida Djalma Batista, 3578, Manaus, 69050-010, Brazil., Luz K; Centro de Pesquisas Clínicas de Natal, Rua Dr. Ponciano Barbosa, 282, Cidade Alta, Natal - RN, 59025-050, Brazil., Aoki FH; Universidade Estadual de Campinas, Cidade Universitária Zeferino Vaz - Barão Geraldo, Campinas - SP, 13083-970, Brazil., Freitas ARR; São Leopoldo Mandic College, Rua Dr. José Rocha Junqueira, 13 - Pte. Preta, Campinas - SP, 13045-755, Brazil., Calvet GA; Instituto Nacional de Infectologia Evandro Chagas (INI/Fiocruz), Avenida Brasil 4.365, Manguinhos, Rio de Janeiro - RJ, 21.040-900, Brazil., Oliveira E; GSK, Estrada dos Bandeirantes, 8464, Jacarepaguá, Rio de Janeiro - RJ, 22775-610, Brazil., Branco BF; GSK, Estrada dos Bandeirantes, 8464, Jacarepaguá, Rio de Janeiro - RJ, 22775-610, Brazil., Abreu A; GSK, Estrada dos Bandeirantes, 8464, Jacarepaguá, Rio de Janeiro - RJ, 22775-610, Brazil., Cheuvart B; GSK, Avenue Fleming 20, Wavre, 1300, Belgium., Guignard A; GSK, Avenue Fleming 20, Wavre, 1300, Belgium., de Boer M; GSK, 14200 Shady Grove Road, Rockville, MD 20850, USA. Electronic address: melanie.x.de-boer@gsk.com., Duarte AC; Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos/Fiocruz, Avenida Brasil 4.365, Manguinhos, Rio de Janeiro - RJ, 21.040-900, Brazil., Borges MB; Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos/Fiocruz, Avenida Brasil 4.365, Manguinhos, Rio de Janeiro - RJ, 21.040-900, Brazil., de Noronha TG; Instituto de Tecnologia em Imunobiológicos Bio-Manguinhos/Fiocruz, Avenida Brasil 4.365, Manguinhos, Rio de Janeiro - RJ, 21.040-900, Brazil.
المصدر: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases [Int J Infect Dis] 2021 Jul; Vol. 108, pp. 443-453. Date of Electronic Publication: 2021 Apr 21.
نوع المنشور: Journal Article; Multicenter Study
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Canada NLM ID: 9610933 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-3511 (Electronic) Linking ISSN: 12019712 NLM ISO Abbreviation: Int J Infect Dis Subsets: MEDLINE
أسماء مطبوعة: Publication: Hamilton, ON : Elsevier
Original Publication: Hamilton, ON : Decker, c1996-
مواضيع طبية MeSH: Dengue/*epidemiology, Adolescent ; Adult ; Asymptomatic Infections/epidemiology ; Brazil/epidemiology ; Child ; Child, Preschool ; Cohort Studies ; Dengue Virus/immunology ; Family Characteristics ; Female ; Humans ; Incidence ; Male ; Middle Aged ; Prospective Studies ; Seroepidemiologic Studies ; Young Adult
مستخلص: Objectives: To estimate the incidence of dengue infection across geographically distinct areas of Brazil.
Methods: This prospective, household-based, cohort study enrolled participants in five areas and followed them up for up to 4 years (2014-2018). Dengue seroprevalence was assessed at each scheduled visit. Suspected dengue cases were identified through enhanced passive and active surveillance. Acute symptomatic dengue infection was confirmed through reverse-transcriptase quantitative polymerase chain reaction in combination with an antigenic assay (non-structural protein 1) and serology.
Results: Among 3300 participants enrolled, baseline seroprevalence was 76.2%, although only 23.3% of participants reported a history of dengue. Of 1284 suspected symptomatic dengue cases detected, 50 (3.9%) were laboratory-confirmed. Based on 8166.5 person-years (PY) of follow-up, the incidence of laboratory-confirmed symptomatic infection (primary endpoint) was 6.1 per 1000 PY (95% confidence interval [CI]: 4.5, 8.1). Incidence varied substantially in different years (1.8-7.4 per 1000 PY). The incidence of inapparent primary dengue infection was substantially higher: 41.7 per 1000 PY (95% CI: 31.1, 54.6).
Conclusions: Our findings, highlighting that the incidence of dengue infection is underestimated in Brazil, will inform the design and implementation of future dengue vaccine trials.
Clinical Trial Registration: NCT01751139.
(Copyright © 2021 GlaxoSmithKline Biologicals SA. Published by Elsevier Ltd.. All rights reserved.)
فهرسة مساهمة: Keywords: Brazil (max 6); Dengue; Epidemiology; Incidence; Multicentre cohort study; Seroprevalence
سلسلة جزيئية: ClinicalTrials.gov NCT01751139
تواريخ الأحداث: Date Created: 20210424 Date Completed: 20210810 Latest Revision: 20210810
رمز التحديث: 20221213
DOI: 10.1016/j.ijid.2021.04.062
PMID: 33894353
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-3511
DOI:10.1016/j.ijid.2021.04.062