دورية أكاديمية
Predicting the disaster - The role of CRP in acetabular surgery.
| العنوان: | Predicting the disaster - The role of CRP in acetabular surgery. |
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| المؤلفون: | Saul D; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Germany; Kogod Center on Aging and Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: Dominik.Saul@med.uni-goettingen.de., Hünicke P; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Germany., Böker KO; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Germany., Spering C; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Germany., Maheshwari AK; Kogod Center on Aging and Division of Endocrinology, Mayo Clinic, Rochester, MN 55905, USA., Acharya M; Trauma & Orthopaedics, Southmead Hospital, Bristol BS10 5NB, United Kingdom., Lehmann W; Department of Trauma, Orthopedics and Reconstructive Surgery, Georg-August-University of Goettingen, Germany. |
| المصدر: | Clinical biochemistry [Clin Biochem] 2021 Aug; Vol. 94, pp. 48-55. Date of Electronic Publication: 2021 Apr 23. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 0133660 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2933 (Electronic) Linking ISSN: 00099120 NLM ISO Abbreviation: Clin Biochem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Science Original Publication: [Toronto] Canadian Society of Clinical Chemists. |
| مواضيع طبية MeSH: | C-Reactive Protein/*metabolism, Acetabulum/injuries ; Acetabulum/surgery ; Humans ; Leukocyte Count ; Models, Theoretical ; Postoperative Period ; Predictive Value of Tests ; ROC Curve ; Retrospective Studies ; Surgical Wound Infection/metabolism |
| مستخلص: | Objectives: Acetabular fractures represent a complex surgical challenge. Given the heterogenous fracture pattern, the patient characteristics and spectrum of complications demand individual solutions. Surgical site infections (SSI) threaten osteosynthesis, and early detection of them and treatment remain crucial. What is the value of postoperative C-reactive protein (CRP) in this group of patients as well as its normal course? Design & Methods: 115 patients with isolated fractures of the acetabulum were retrospectively evaluated. CRP, white blood cell count (WBC) and fracture patterns as well as patient characteristics were assessed for 20 days following operative fixation of the acetabular fracture (n = 71) and in fractures that were managed conservatively (n = 44). Results: Twelve patients suffered an infectious complication. With a one-phase decay, 70.55% of the variance of postoperative CRP kinetics was predicted. To anticipate maximum CRP as well as an infection, the preoperative CRP represented the best prognostic parameter. To predict an infection, the single variable "peak CRP value above 100 mg/l" resulted in a sensitivity and specificity of 91.67% and 36.21%, respectively. Combining a second peak of CRP with maximum CRP and day 5 CRP value for receiver-operating characteristic (ROC) analysis resulted in 83.3% and 88.1%, respectively. Conclusions: Predicting surgical site infections after an acetabular fracture is most predictive when analyzing the maximum overall CRP, the second peak and the CRP after day 5. With a combination of these parameters, a sensitivity and specificity of 83.3% and 88.1% to detect an infection was achieved. (Copyright © 2021 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Acetabulum fracture; C-reactive protein; CRP; Pelvic surgery; Revision surgery |
| المشرفين على المادة: | 9007-41-4 (C-Reactive Protein) |
| تواريخ الأحداث: | Date Created: 20210425 Date Completed: 20210809 Latest Revision: 20210809 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.clinbiochem.2021.04.020 |
| PMID: | 33895126 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-2933 |
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| DOI: | 10.1016/j.clinbiochem.2021.04.020 |