دورية أكاديمية
أعرض في EDS

Living Alone and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction.

التفاصيل البيبلوغرافية
العنوان: Living Alone and Clinical Outcomes in Patients With Heart Failure With Preserved Ejection Fraction.
المؤلفون: Zhu W; From the Department of Cardiology (Zhu, Y. Wu, Zhou, Liang, Xue, Z. Wu, D. Wu, He, Dong, Liu), the First Affiliated Hospital of Sun Yat-sen University; NHC Key Laboratory of Assisted Circulation (Zhu, Y. Wu, Zhou, Liang, Xue, Z. Wu, D. Wu, He, Dong, Liu), Sun Yat-sen University; and National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular Diseases (Dong, Liu), Guangzhou, PR China., Wu Y, Zhou Y, Liang W, Xue R, Wu Z, Wu D, He J, Dong Y, Liu C
المصدر: Psychosomatic medicine [Psychosom Med] 2021 Jun 01; Vol. 83 (5), pp. 470-476.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins Country of Publication: United States NLM ID: 0376505 Publication Model: Print Cited Medium: Internet ISSN: 1534-7796 (Electronic) Linking ISSN: 00333174 NLM ISO Abbreviation: Psychosom Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Hagerstown, MD : Lippincott Williams & Wilkins
Original Publication: Baltimore [etc.]
مواضيع طبية MeSH: Heart Failure*/epidemiology, Female ; Heart ; Hospitalization ; Humans ; Male ; Mineralocorticoid Receptor Antagonists ; Prognosis ; Stroke Volume
مستخلص: Objective: In patients with heart failure with preserved ejection fraction (HFpEF), whether living alone could contribute to a poor prognosis remains unknown. We sought to investigate the association of living alone with clinical outcomes in patients with HFpEF.
Methods: Symptomatic patients with HFpEF with a follow-up of 3.3 years (data collected from August 2006 to June 2013) in the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist trial were classified as patients living alone and those living with others. The primary outcome was defined as a composite of cardiovascular death, aborted cardiac arrest, or HF hospitalization.
Results: A total of 3103 patients with HFpEF were included; 25.2% of them were living alone and were older, predominantly female, and less likely to be White and have more comorbidities compared with the other patients. After multivariate adjustment for confounders, living alone was associated with increased risks of HF hospitalization (hazard ratio [HR] = 1.29, 95% confidence interval [CI] = 1.03-1.61) and any hospitalization (HR = 1.26, 95% CI = 1.12-1.42). A significantly increased risk of any hospitalization (HR = 1.16, 95% CI = 1.01-1.34) was also observed in the Americas-based sample. In addition, each year increase in age, female sex, non-White race, New York Heart Association functional classes III and IV, dyslipidemia, and chronic obstructive pulmonary disease were independently associated with living alone.
Conclusions: We assessed the effect of living arrangement status on clinical outcomes in patients with HFpEF and suggested that living alone was associated with an independent increase in any hospitalization.Clinical Trial Registration: ClinicalTrials.gov identifier: NCT00094302.
(Copyright © 2021 by the American Psychosomatic Society.)
References: van der Meer P, Gaggin HK, Dec GW. ACC/AHA versus ESC guidelines on heart failure: JACC guideline comparison. J Am Coll Cardiol 2019;73:2756–68.
Sokoreli I, Pauws SC, Steyerberg EW, de Vries GJ, Riistama JM, Tesanovic A, Kazmi S, Pellicori P, Cleland JG, Clark AL. Prognostic value of psychosocial factors for first and recurrent hospitalizations and mortality in heart failure patients: insights from the OPERA-HF study. Eur J Heart Fail 2018;20:689–96.
Lin TK, Hsu BC, Li YD, Chen CH, Lin JW, Chien CY, Weng CY. Prognostic value of anxiety between heart failure with reduced ejection fraction and heart failure with preserved ejection fraction. J Am Heart Assoc 2019;8:e010739.
Heidari Gorji MA, Fatahian A, Farsavian A. The impact of perceived and objective social isolation on hospital readmission in patients with heart failure: a systematic review and meta-analysis of observational studies. Gen Hosp Psychiatry 2019;60:27–36.
Manemann SM, Chamberlain AM, Roger VL, Griffin JM, Boyd CM, Cudjoe TKM, Jensen D, Weston SA, Fabbri M, Jiang R, Finney Rutten LJ. Perceived social isolation and outcomes in patients with heart failure. J Am Heart Assoc 2018;7:e008069.
Chin MH, Goldman L. Correlates of early hospital readmission or death in patients with congestive heart failure. Am J Cardiol 1997;79:1640–4.
Jensen MT, Marott JL, Holtermann A, Gyntelberg F. Living alone is associated with all-cause and cardiovascular mortality: 32 years of follow-up in the Copenhagen Male Study. Eur Heart J Qual Care Clin Outcomes 2019;5:208–17.
Holt-Lunstad J, Smith TB, Baker M, Harris T, Stephenson D. Loneliness and social isolation as risk factors for mortality: a meta-analytic review. Perspect Psychol Sci 2015;10:227–37.
Lu MLR, Davila CD, Shah M, Wheeler DS, Ziccardi MR, Banerji S, Figueredo VM. Marital status and living condition as predictors of mortality and readmissions among African Americans with heart failure. Int J Cardiol 2016;222:313–8.
Huynh Q, Negishi K, De Pasquale C, Hare J, Leung D, Stanton T, Marwick TH. Effects of post-discharge management on rates of early re-admission and death after hospitalisation for heart failure. Med J Aust 2018;208:485–91.
Huynh QL, Saito M, Blizzard CL, Eskandari M, Johnson B, Adabi G, Hawson J, Negishi K, Marwick TH, Huynh Q, Marwick T, DePasquale C, Leung D, Hare J, Stanton T. Roles of nonclinical and clinical data in prediction of 30-day rehospitalization or death among heart failure patients. J Card Fail 2015;21:374–81.
Luttik ML, Jaarsma T, Veeger N, van Veldhuisen DJ. Marital status, quality of life, and clinical outcome in patients with heart failure. Heart Lung 2006;35:3–8.
Pitt B, Pfeffer MA, Assmann SF, Boineau R, Anand IS, Claggett B, Clausell N, Desai AS, Diaz R, Fleg JL, Gordeev I, Harty B, Heitner JF, Kenwood CT, Lewis EF, O’Meara E, Probstfield JL, Shaburishvili T, Shah SJ, Solomon SD, Sweitzer NK, Yang S, McKinlay SM; TOPCAT Investigators. Spironolactone for heart failure with preserved ejection fraction. N Engl J Med 2014;370:1383–92.
Zavaleta D, Samuel K, Mills CT. Measures of social isolation. Soc Indic Res 2017;131:367–91.
Leigh-Hunt N, Bagguley D, Bash K, Turner V, Turnbull S, Valtorta N, Caan W. An overview of systematic reviews on the public health consequences of social isolation and loneliness. Public Health 2017;152:157–71.
Alun J, Murphy B. Loneliness, social isolation and cardiovascular risk. Br J Cardiac Nurs 2019;14:1–8.
Brinkhues S, Dukers-Muijrers NHTM, Hoebe CJPA, van der Kallen CJH, Dagnelie PC, Koster A, Henry RMA, Sep SJS, Schaper NC, Stehouwer CDA, Bosma H, Savelkoul PHM, Schram MT. Socially isolated individuals are more prone to have newly diagnosed and prevalent type 2 diabetes mellitus—the Maastricht study. BMC Public Health 2017;17:955.
Case RB, Moss AJ, Case N, McDermott M, Eberly S. Living alone after myocardial infarction. Impact on prognosis. JAMA 1992;267:515–9.
Lammintausta A, Airaksinen JK, Immonen-Räihä P, Torppa J, Kesäniemi AY, Ketonen M, Koukkunen H, Kärjä-Koskenkari P, Lehto S, Salomaa V; FINAMI Study Group. Prognosis of acute coronary events is worse in patients living alone: the FINAMI myocardial infarction register. Eur J Prev Cardiol 2013;21:989–96.
Gandhi S, Goodman SG, Greenlaw N, Ford I, McSkimming P, Ferrari R, Jang Y, Alcocer-Gamba MA, Fox K, Tardif JC, Tendera M, Dorian P, Steg G, Udell JA. Living alone and cardiovascular disease outcomes. Heart 2019;105:1087–95.
Schmaltz HN, Southern D, Ghali WA, Jelinski SE, Parsons GA, King KM, Maxwell CJ. Living alone, patient sex and mortality after acute myocardial infarction. J Gen Intern Med 2007;22:572–8.
Kilpi F, Konttinen H, Silventoinen K, Martikainen P. Living arrangements as determinants of myocardial infarction incidence and survival: a prospective register study of over 300,000 Finnish men and women. Soc Sci Med 2015;133:93–100.
Kitamura T, Sakata Y, Nakatani D, Suna S, Usami M, Matsumoto S, Hara M, Hamasaki T, Nanto S, Sato H, Hori M, Iso H, Komuro I. Living alone and risk of cardiovascular events following discharge after acute myocardial infarction in Japan. J Cardiol 2013;62:257–62.
Udell JA, Steg PG, Scirica BM, Smith SC Jr., Ohman EM, Eagle KA, Goto S, Cho JI, Bhatt DL; REduction of Atherothrombosis for Continued Health (REACH) Registry Investigators. Living alone and cardiovascular risk in outpatients at risk of or with atherothrombosis. Arch Intern Med 2012;172:1086–95.
Li H, Xia N. The role of oxidative stress in cardiovascular disease caused by social isolation and loneliness. Redox Biol 2020;37:101585.
Xia N, Li H. Loneliness, social isolation, and cardiovascular health. Antioxid Redox Signal 2018;28:837–51.
سلسلة جزيئية: ClinicalTrials.gov NCT00094302
المشرفين على المادة: 0 (Mineralocorticoid Receptor Antagonists)
تواريخ الأحداث: Date Created: 20210426 Date Completed: 20211020 Latest Revision: 20220531
رمز التحديث: 20231215
DOI: 10.1097/PSY.0000000000000945
PMID: 33901053
قاعدة البيانات: MEDLINE
الوصف
تدمد:1534-7796
DOI:10.1097/PSY.0000000000000945