دورية أكاديمية
The chorioallantoic membrane as a bio-barrier model for the evaluation of nanoscale drug delivery systems for tumour therapy.
| العنوان: | The chorioallantoic membrane as a bio-barrier model for the evaluation of nanoscale drug delivery systems for tumour therapy. |
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| المؤلفون: | Preis E; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany., Schulze J; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany., Gutberlet B; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany., Pinnapireddy SR; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany; CSL Behring Innovation GmbH, Emil-von-Behring-Str. 76, 35041 Marburg, Germany., Jedelská J; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany; Center for Tumor Biology and Immunology, Core Facility for Small Animal MRI, Hans-Meerwein Str. 3, 35043 Marburg, Germany., Bakowsky U; Department of Pharmaceutics and Biopharmaceutics, University of Marburg, Robert-Koch-Str. 4, 35037 Marburg, Germany. Electronic address: ubakowsky@aol.com. |
| المصدر: | Advanced drug delivery reviews [Adv Drug Deliv Rev] 2021 Jul; Vol. 174, pp. 317-336. Date of Electronic Publication: 2021 Apr 24. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Publishers, B.V Country of Publication: Netherlands NLM ID: 8710523 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1872-8294 (Electronic) Linking ISSN: 0169409X NLM ISO Abbreviation: Adv Drug Deliv Rev Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier Science Publishers, B.V., c1987- |
| مواضيع طبية MeSH: | Drug Delivery Systems*, Chorioallantoic Membrane/*drug effects , Neoplasms/*drug therapy, Animal Use Alternatives ; Animals ; Antineoplastic Agents/administration & dosage ; Chorioallantoic Membrane/metabolism ; Humans ; Nanoparticles ; Xenograft Model Antitumor Assays/methods |
| مستخلص: | In 2010, the European Parliament and the European Union adopted a directive on the protection of animals used for scientific purposes. The directive aims to protect animals in scientific research, with the final goal of complete replacement of procedures on live animals for scientific and educational purposes as soon as it is scientifically viable. Furthermore, the directive announces the implementation of the 3Rs principle: "When choosing methods, the principles of replacement, reduction and refinement should be implemented through a strict hierarchy of the requirement to use alternative methods." The visibility, accessibility, and the rapid growth of the chorioallantoic membrane (CAM) offers a clear advantage for various manipulations and for the simulation of different Bio-Barriers according to the 3R principle. The extensive vascularisation on the CAM provides an excellent substrate for the cultivation of tumour cells or tumour xenografts which could be used for the therapeutic evaluation of nanoscale drug delivery systems. The tumour can be targeted either by topical application, intratumoural injection or i.v. injection. Different application sites and biological barriers can be examined within a single model. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Biocompatibility; CAM; Cancer; Egg; Ex ovo; Ex vivo; Liposomes; Nanoparticles |
| المشرفين على المادة: | 0 (Antineoplastic Agents) |
| تواريخ الأحداث: | Date Created: 20210427 Date Completed: 20220104 Latest Revision: 20220104 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.addr.2021.04.022 |
| PMID: | 33905805 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1872-8294 |
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| DOI: | 10.1016/j.addr.2021.04.022 |