دورية أكاديمية
أعرض في EDS

Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed.

التفاصيل البيبلوغرافية
العنوان: Counteracting the Ramifications of UVB Irradiation and Photoaging with Swietenia macrophylla King Seed.
المؤلفون: Mahendra CK; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia., Abidin SAZ; Liquid Chromatography Mass Spectrometry (LCMS) Platform, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Jalan Lagoon Selatan, Bandar Sunway 47500, Malaysia., Htar TT; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia., Chuah LH; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia., Khan SU; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia.; Department of Pharmacy, Abasyn University, Peshawar 25000, Pakistan., Ming LC; PAP Rashidah Sa'adatul Bolkiah Institute of Health Sciences, Universiti Brunei Darussalam, Gadong BE1410, Brunei., Tang SY; Chemical Engineering Discipline, School of Engineering, Monash University Malaysia, Bandar Sunway 47500, Malaysia.; Advanced Engineering Platform, School of Engineering, Monash University Malaysia, Bandar Sunway 47500, Malaysia.; Tropical Medicine and Biology Platform, School of Science, Monash University Malaysia, Bandar Sunway 47500, Malaysia., Pusparajah P; Medical Health and Translational Research Group, Jeffrey Cheah School of Medicine and Health Sciences, Monash University Malaysia, Bandar Sunway 47500, Malaysia., Goh BH; Biofunctional Molecule Exploratory Research Group, School of Pharmacy, Monash University Malaysia, Bandar Sunway 47500, Malaysia.; College of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.; Health and Well-Being Cluster, Global Asia in the 21st Century (GA21) Platform, Monash University Malaysia, Bandar Sunway 47500, Malaysia.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Apr 01; Vol. 26 (7). Date of Electronic Publication: 2021 Apr 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Meliaceae/*chemistry , Plant Extracts/*pharmacology , Seeds/*chemistry , Skin Aging/*drug effects , Skin Aging/*radiation effects , Ultraviolet Rays/*adverse effects, Apoptosis/drug effects ; Apoptosis/radiation effects ; Biological Products/chemistry ; Biological Products/pharmacology ; Cell Proliferation/drug effects ; Cell Proliferation/radiation effects ; Cell Survival/drug effects ; Cell Survival/radiation effects ; Chromatography, Liquid ; Cosmetics ; Epidermis/drug effects ; Epidermis/metabolism ; Epidermis/radiation effects ; Gene Expression Profiling/methods ; Humans ; Keratinocytes/drug effects ; Keratinocytes/metabolism ; Keratinocytes/radiation effects ; Mass Spectrometry ; Oxidation-Reduction/drug effects ; Plant Extracts/chemistry ; Proteomics/methods
مستخلص: In this day and age, the expectation of cosmetic products to effectively slow down skin photoaging is constantly increasing. However, the detrimental effects of UVB on the skin are not easy to tackle as UVB dysregulates a wide range of molecular changes on the cellular level. In our research, irradiated keratinocyte cells not only experienced a compromise in their redox system, but processes from RNA translation to protein synthesis and folding were also affected. Aside from this, proteins involved in various other processes like DNA repair and maintenance, glycolysis, cell growth, proliferation, and migration were affected while the cells approached imminent cell death. Additionally, the collagen degradation pathway was also activated by UVB irradiation through the upregulation of inflammatory and collagen degrading markers. Nevertheless, with the treatment of Swietenia macrophylla ( S. macrophylla ) seed extract and fractions, the dysregulation of many genes and proteins by UVB was reversed. The reversal effects were particularly promising with the S. macrophylla hexane fraction (SMHF) and S. macrophylla ethyl acetate fraction (SMEAF). SMHF was able to oppose the detrimental effects of UVB in several different processes such as the redox system, DNA repair and maintenance, RNA transcription to translation, protein maintenance and synthesis, cell growth, migration and proliferation, and cell glycolysis, while SMEAF successfully suppressed markers related to skin inflammation, collagen degradation, and cell apoptosis. Thus, in summary, our research not only provided a deeper insight into the molecular changes within irradiated keratinocytes, but also serves as a model platform for future cosmetic research to build upon. Subsequently, both SMHF and SMEAF also displayed potential photoprotective properties that warrant further fractionation and in vivo clinical trials to investigate and obtain potential novel bioactive compounds against photoaging.
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معلومات مُعتمدة: vote no. GBA-81811A External Industry Grants from Biotek Abadi Sdn Bhd; GA-HW-19-L01 & GA-HW-19-S02 Monash Global Asia in the 21st Century (GA21) research grant; FRGS/1/2019/WAB09/MUSM/02/1 Fundamental Research Grant Scheme
فهرسة مساهمة: Keywords: LC-MS/MS; Swietenia macrophylla; UV irradiation; cosmetics; epidermal layer; genomics; keratinocytes; natural product; photoaging; proteomics
المشرفين على المادة: 0 (Biological Products)
0 (Cosmetics)
0 (Plant Extracts)
تواريخ الأحداث: Date Created: 20210430 Date Completed: 20210524 Latest Revision: 20210524
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8037697
DOI: 10.3390/molecules26072000
PMID: 33916053
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules26072000