دورية أكاديمية
أعرض في EDS

Antiretroviral Drugs Impact Autophagy with Toxic Outcomes.

التفاصيل البيبلوغرافية
العنوان: Antiretroviral Drugs Impact Autophagy with Toxic Outcomes.
المؤلفون: Cheney L; Division of Infectious Diseases, Department of Medicine, Montefiore Medical Center and Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA., Barbaro JM; Department of Pathology, Montefiore Medical Center and Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA., Berman JW; Department of Pathology, Montefiore Medical Center and Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.; Department of Microbiology and Immunology, Montefiore Medical Center and Albert Einstein College of Medicine, 1300 Morris Park Ave, Bronx, NY 10461, USA.
المصدر: Cells [Cells] 2021 Apr 15; Vol. 10 (4). Date of Electronic Publication: 2021 Apr 15.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Review
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI
مواضيع طبية MeSH: Anti-Retroviral Agents/*toxicity , Autophagy/*drug effects, Animals ; Drug Therapy, Combination ; HIV/drug effects ; Humans ; Protease Inhibitors/pharmacology ; Reverse Transcriptase Inhibitors/pharmacology
مستخلص: Antiretroviral drugs have dramatically improved the morbidity and mortality of people living with HIV (PLWH). While current antiretroviral therapy (ART) regimens are generally well-tolerated, risks for side effects and toxicity remain as PLWH must take life-long medications. Antiretroviral drugs impact autophagy, an intracellular proteolytic process that eliminates debris and foreign material, provides nutrients for metabolism, and performs quality control to maintain cell homeostasis. Toxicity and adverse events associated with antiretrovirals may be due, in part, to their impacts on autophagy. A more complete understanding of the effects on autophagy is essential for developing antiretroviral drugs with decreased off target effects, meaning those unrelated to viral suppression, to minimize toxicity for PLWH. This review summarizes the findings and highlights the gaps in our knowledge of the impacts of antiretroviral drugs on autophagy.
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معلومات مُعتمدة: T32GM00728846 United States NH NIH HHS; 5R01DA044584 United States NH NIH HHS; R01 MH112391 United States MH NIMH NIH HHS; 5R01DA048609 United States NH NIH HHS; R01 DA044584 United States DA NIDA NIH HHS; T32 GM007288 United States GM NIGMS NIH HHS; P30 AI124414 United States AI NIAID NIH HHS; T32 AI070117 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: ER stress; HIV; antiretroviral drugs; autophagy; mitochondria; mitophagy; side effects; toxicity
المشرفين على المادة: 0 (Anti-Retroviral Agents)
0 (Protease Inhibitors)
0 (Reverse Transcriptase Inhibitors)
تواريخ الأحداث: Date Created: 20210430 Date Completed: 20211020 Latest Revision: 20240814
رمز التحديث: 20240814
مُعرف محوري في PubMed: PMC8071244
DOI: 10.3390/cells10040909
PMID: 33920955
قاعدة البيانات: MEDLINE
الوصف
تدمد:2073-4409
DOI:10.3390/cells10040909