دورية أكاديمية
أعرض في EDS

Malignant Ascites Promote Adhesion of Ovarian Cancer Cells to Peritoneal Mesothelium and Fibroblasts.

التفاصيل البيبلوغرافية
العنوان: Malignant Ascites Promote Adhesion of Ovarian Cancer Cells to Peritoneal Mesothelium and Fibroblasts.
المؤلفون: Uruski P; Department of Hypertensiology, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland., Mikuła-Pietrasik J; Department of Pathophysiology of Ageing and Civilization Diseases, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland., Pakuła M; Department of Hypertensiology, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland., Budkiewicz S; Department of Pathophysiology of Ageing and Civilization Diseases, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland., Drzewiecki M; Department of Pathophysiology of Ageing and Civilization Diseases, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland., Gaiday AN; Department of Obstetrics and Gynecology, West Kazakhstan Marat Ospanov Medical University, 50B 12th Microdistrict Apt.21, Aktobe 030008, Kazakhstan., Wierzowiecka M; Department of Hypertensiology, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland., Naumowicz E; General Surgery Ward, Medical Centre HCP, 28 Czerwca 1956 r. 223/229 Str., 61-485 Poznan, Poland., Moszyński R; Division of Gynecological Surgery, Poznan University of Medical Sciences, Polna 33 Str., 60-535 Poznan, Poland., Tykarski A; Department of Hypertensiology, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland., Książek K; Department of Pathophysiology of Ageing and Civilization Diseases, Poznan University of Medical Sciences, Długa 1/2 Str., 61-848 Poznan, Poland.
المصدر: International journal of molecular sciences [Int J Mol Sci] 2021 Apr 19; Vol. 22 (8). Date of Electronic Publication: 2021 Apr 19.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101092791 Publication Model: Electronic Cited Medium: Internet ISSN: 1422-0067 (Electronic) Linking ISSN: 14220067 NLM ISO Abbreviation: Int J Mol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, [2000-
مواضيع طبية MeSH: Ascites/*metabolism , Ascites/*pathology , Cell Adhesion/*physiology , Ovarian Neoplasms/*metabolism, Apoptosis/physiology ; Carcinoma, Ovarian Epithelial/metabolism ; Carcinoma, Ovarian Epithelial/pathology ; Cell Line, Tumor ; Cells, Cultured ; Female ; Fibroblasts/metabolism ; Fibroblasts/pathology ; Flow Cytometry ; Fluorescent Antibody Technique ; Humans ; Ovarian Neoplasms/pathology ; Peritoneal Neoplasms/metabolism ; Peritoneal Neoplasms/pathology ; Peritoneum/metabolism ; Peritoneum/pathology
مستخلص: Although malignant ascites (MAs) are known to contribute to various aspects of ovarian cancer progression, knowledge regarding their role in the adhesion of cancer cells to normal peritoneal cells is incomplete. Here, we compared the effect of MAs and benign ascites (BAs) on the adhesion of A2780 and OVCAR-3 cancer cells to omentum-derived peritoneal mesothelial cells (PMCs) and peritoneal fibroblasts (PFBs). The results showed that MAs stimulated the adhesion of A2780 and OVCAR-3 cells to PMCs and PFBs more efficiently than did BAs, and the strongest binding occurred when both cancer and normal cells were exposed to the fluid. Intervention studies showed that MAs-driven adhesion of A2780 cells to PMCs/PFBs depends on the presence of TGF-β1 and HGF, whereas binding of OVCAR-3 cells was mediated by TGF-β1, GRO-1, and IGF-1. Moreover, MAs upregulated α5β1 integrin expression on PFBs but not on PMCs or cancer cells, vimentin expression in all cells tested, and ICAM-1 only in cancer cells. When integrin-linked kinase was neutralized in PMCs or PFBs, cancer cell adhesion to PMCs and PFBs decreased. Collectively, our report shows that MAs may contribute to the early stages of ovarian cancer metastasis by modulating the proadhesive interplay between normal and cancer cells.
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معلومات مُعتمدة: 2017/25/B/NZ3/00122 Narodowe Centrum Nauki; 2020/37/B/NZ5/00100 Narodowe Centrum Nauki; SHIP-2.3/CS-02 Ministry of Education and Science of the Republic of Kazakhstan
فهرسة مساهمة: Keywords: cancer cell adhesion; malignant ascites; ovarian cancer; peritoneal metastases
تواريخ الأحداث: Date Created: 20210430 Date Completed: 20210524 Latest Revision: 20210524
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8073321
DOI: 10.3390/ijms22084222
PMID: 33921783
قاعدة البيانات: MEDLINE
الوصف
تدمد:1422-0067
DOI:10.3390/ijms22084222