دورية أكاديمية
أعرض في EDS

The Use of Imaging Techniques in Chronic Kidney Disease-Mineral and Bone Disorders (CKD-MBD)-A Systematic Review.

التفاصيل البيبلوغرافية
العنوان: The Use of Imaging Techniques in Chronic Kidney Disease-Mineral and Bone Disorders (CKD-MBD)-A Systematic Review.
المؤلفون: Pimentel A; Department of Dialysis AURA Nord Saint Ouen, 93400 Saint Ouen, France., Bover J; Fundació Puigvert, Department of Nephrology, IIB Sant Pau, RedinRen, Barcelona, 08025 Catalonia, Spain., Elder G; Department of Renal Medicine, Westmead Hospital, Sydney, NSW 2145, Australia., Cohen-Solal M; Bioscar INSERM U1132, Department of Rheumatology, Université de Paris, Hôpital Lariboisière, 75010 Paris, France., Ureña-Torres PA; Department of Dialysis AURA Nord Saint Ouen, 93400 Saint Ouen, France.; Department of Renal Physiology, Necker Hospital, University of Paris Descartes, 75015 Paris, France.
المصدر: Diagnostics (Basel, Switzerland) [Diagnostics (Basel)] 2021 Apr 26; Vol. 11 (5). Date of Electronic Publication: 2021 Apr 26.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101658402 Publication Model: Electronic Cited Medium: Print ISSN: 2075-4418 (Print) Linking ISSN: 20754418 NLM ISO Abbreviation: Diagnostics (Basel) Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2011]-
مستخلص: Although frequently silent, mineral and bone disease (MBD) is one of the most precocious complication of chronic kidney disease (CKD) and is omnipresent in patients with CKD stage 5. Its pathophysiology is complex, but basically, disturbances in vitamin D, phosphate, and calcium metabolism lead to a diverse range of clinical manifestations with secondary hyperparathyroidism usually being the most frequent. With the decline in renal function, CKD-MBD may induce microstructural changes in bone, vascular system and soft tissues, which results in macrostructural lesions, such as low bone mineral density (BMD) resulting in skeletal fractures, vascular and soft tissue calcifications. Moreover, low BMD, fractures, and vascular calcifications are linked with increased risk of cardiovascular mortality and all-cause mortality. Therefore, a better characterization of CKD-MBD patterns, beyond biochemical markers, is helpful to adapt therapies and monitor strategies as used in the general population. An in-depth characterization of bone health is required, which includes an evaluation of cortical and trabecular bone structure and density and the degree of bone remodeling through bone biomarkers. Standard radiological imaging is generally used for the diagnosis of fracture or pseudo-fractures, vascular calcifications and other features of CKD-MBD. However, bone fractures can also be diagnosed using computed tomography (CT) scan, magnetic resonance (MR) imaging and vertebral fracture assessment (VFA). Fracture risk can be predicted by bone densitometry using dual-energy X-ray absorptiometry (DXA), quantitative computed tomography (QTC) and peripheral quantitative computed tomography (pQTC), quantitative ultrasound (QUS) and most recently magnetic resonance micro-imaging. Quantitative methods to assess bone consistency and strength complete the study and adjust the clinical management when integrated with clinical factors. The aim of this review is to provide a brief and comprehensive update of imaging techniques available for the diagnosis, prevention, treatment and monitoring of CKD-MBD.
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فهرسة مساهمة: Keywords: CKD-MBD; bone; bone mineral density; computed tomography; cortical bone; dual-energy X-ray absorptiometry; fracture; trabecular bone
تواريخ الأحداث: Date Created: 20210430 Latest Revision: 20210527
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8146279
DOI: 10.3390/diagnostics11050772
PMID: 33925796
قاعدة البيانات: MEDLINE
الوصف
تدمد:2075-4418
DOI:10.3390/diagnostics11050772