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Intestinal Dysbiosis Disguised as a Rectal Fistula Treated With Autologous Fecal Microbiota Transplantation.

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العنوان: Intestinal Dysbiosis Disguised as a Rectal Fistula Treated With Autologous Fecal Microbiota Transplantation.
المؤلفون: Scibelli N; Internal Medicine, Grand Strand Medical Center, Myrtle Beach, USA., Singh P; Internal Medicine, Grand Strand Medical Center, Myrtle Beach, USA., Raynor K; Gastroenterology, Grand Strand Medical Center, Myrtle Beach, USA.
المصدر: Cureus [Cureus] 2021 Mar 25; Vol. 13 (3), pp. e14115. Date of Electronic Publication: 2021 Mar 25.
نوع المنشور: Case Reports
اللغة: English
بيانات الدورية: Publisher: Cureus, Inc Country of Publication: United States NLM ID: 101596737 Publication Model: Electronic Cited Medium: Print ISSN: 2168-8184 (Print) Linking ISSN: 21688184 NLM ISO Abbreviation: Cureus Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Palo Alto, CA : Cureus, Inc.
مستخلص: Fecal microbiota transplantation (FMT) has been efficacious in the treatment of intestinal dysbiosis, derangement of the native intestinal microflora, and the indications for autologous FMT are growing. A 69-year-old Caucasian man with a past medical history of paraplegia secondary to motor vehicle accident and sigmoid-end colostomy presented to his gastroenterologist with the complaint of rectal discharge. A complicated medical course pre-dated his presentation and included multiple decubitus ulcers requiring debridement and several courses of broad-spectrum antibiotics. The rectal discharge was initially presumed to be from a fistula leading to one of his ulcers; however, workup with anoscopy, flexible sigmoidoscopy, and magnetic resonance imaging of the pelvis showed no visible perirectal abscess or connection to the sigmoid colon through a fistula. Intestinal dysbiosis was an alternative theory considered to be the cause of his copious rectal discharge due to his several courses of broad-spectrum antibiotics and prolonged inactivity of his gut. This prompted a trial treatment plan utilizing autologous FMT, with the patient administering enemas containing his own stool to the distal limb of his bowel. As a result of this treatment, the patient's chief complaint completely resolved within days of initiating treatment, although symptoms did eventually return. We would like to propose that further randomized studies should be done to investigate autologous FMT as a treatment for patients suffering from intestinal dysbiosis following sigmoid-end colostomy.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright © 2021, Scibelli et al.)
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فهرسة مساهمة: Keywords: autologous fecal microbiota transplant; fecal microbiota transplant; fecal microbiota transplantation; fmt; gut microbiome; intestinal dysbiosis; intestinal microbiome; sigmoid-end colostomy
تواريخ الأحداث: Date Created: 20210430 Latest Revision: 20210502
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8075766
DOI: 10.7759/cureus.14115
PMID: 33927926
قاعدة البيانات: MEDLINE
الوصف
تدمد:2168-8184
DOI:10.7759/cureus.14115