دورية أكاديمية

New perspectives on natural flavonoids on COVID-19-induced lung injuries.

التفاصيل البيبلوغرافية
العنوان: New perspectives on natural flavonoids on COVID-19-induced lung injuries.
المؤلفون: Santana FPR; Department of Bioscience, Federal University of São Paulo, Santos, São Paulo, Brazil.; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil., Thevenard F; Center of Natural Sciences and Humanities, Federal University of ABC, São Paulo, São Paulo, Brazil., Gomes KS; Center of Natural Sciences and Humanities, Federal University of ABC, São Paulo, São Paulo, Brazil., Taguchi L; Department of Bioscience, Federal University of São Paulo, Santos, São Paulo, Brazil., Câmara NOS; Department of Immunology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil., Stilhano RS; Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, São Paulo, Brazil., Ureshino RP; Department of Biological Science, Federal University of São Paulo, Diadema, São Paulo, Brazil., Prado CM; Department of Bioscience, Federal University of São Paulo, Santos, São Paulo, Brazil., Lago JHG; Center of Natural Sciences and Humanities, Federal University of ABC, São Paulo, São Paulo, Brazil.
المصدر: Phytotherapy research : PTR [Phytother Res] 2021 Sep; Vol. 35 (9), pp. 4988-5006. Date of Electronic Publication: 2021 Apr 29.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Wiley Country of Publication: England NLM ID: 8904486 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1099-1573 (Electronic) Linking ISSN: 0951418X NLM ISO Abbreviation: Phytother Res Subsets: MEDLINE
أسماء مطبوعة: Publication: : Chichester : Wiley
Original Publication: London : Heyden & Son, c1987-
مواضيع طبية MeSH: COVID-19*/complications , Flavonoids*/pharmacology , Lung Injury*/drug therapy , Lung Injury*/virology, Humans ; Pandemics
مستخلص: The SARS-CoV-2 virus, responsible for COVID-19, spread rapidly worldwide and became a pandemic in 2020. In some patients, the virus remains in the respiratory tract, causing pneumonia, respiratory failure, acute respiratory distress syndrome (ARDS), and sepsis, leading to death. Natural flavonoids (aglycone and glycosides) possess broad biological activities encompassing antiinflammatory, antiviral, antitumoral, antiallergic, antiplatelet, and antioxidant effects. While many studies have focused on the effects of natural flavonoids in experimental models, reports based on clinical trials are still insufficient. In this review, we highlight the effects of flavonoids in controlling pulmonary diseases, particularly the acute respiratory distress syndrome, a consequence of COVID-19, and their potential use in coronavirus-related diseases. Furthermore, we also focus on establishing a relationship between biological potential and chemical aspects of related flavonoids and discuss several possible mechanisms of action, pointing out some possible effects on COVID-19.
(© 2021 John Wiley & Sons Ltd.)
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معلومات مُعتمدة: 301354/2019-7 Conselho Nacional de Desenvolvimento Científico e Tecnológico; 306278/2015-4 Conselho Nacional de Desenvolvimento Científico e Tecnológico; financial code 001 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; 2018/06088-0 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2018/07885-1 Fundação de Amparo à Pesquisa do Estado de São Paulo; 2020/01221-4 Fundação de Amparo à Pesquisa do Estado de São Paulo
فهرسة مساهمة: Keywords: ACE2; COVID-19; SARS-CoV-2; acute lung injury; flavonoids
المشرفين على المادة: 0 (Flavonoids)
تواريخ الأحداث: Date Created: 20210430 Date Completed: 20210927 Latest Revision: 20220716
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8242604
DOI: 10.1002/ptr.7131
PMID: 33928690
قاعدة البيانات: MEDLINE
الوصف
تدمد:1099-1573
DOI:10.1002/ptr.7131