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Chromolaena laevigata (Asteraceae) as a source of endophytic non-aflatoxigenic Aspergillus flavus: chemical profile in different culture conditions and biological applications.

التفاصيل البيبلوغرافية
العنوان: Chromolaena laevigata (Asteraceae) as a source of endophytic non-aflatoxigenic Aspergillus flavus: chemical profile in different culture conditions and biological applications.
المؤلفون: Balbinot RB; Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., de Oliveira JAM; Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Bernardi DI; Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Polli AD; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Polonio JC; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Cabral MRP; Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Zanqueta ÉB; Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Endo EH; Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Meneguello JE; Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Cardoso RF; Departamento de Análises Clínicas e Biomedicina, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Azevedo JL; Departamento de Genética, Escola Superior de Agricultura Luiz de Queiroz - ESALQ/USP, Universidade de São Paulo, Av. Pádua Dias 11, 13418-900, Piracicaba, São Paulo, Brazil., Dias Filho BP; Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Nakamura TU; Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., do Carmo MRB; Departamento de Biologia Geral, Universidade Estadual de Ponta Grossa, Av. Carlos Cavalcanti, 4778, 84030-910, Ponta Grossa, Paraná, Brazil., Sarragiotto MH; Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Pamphile JA; Departamento de Biotecnologia, Genética e Biologia Celular, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil., Baldoqui DC; Departamento de Química, Universidade Estadual de Maringá, Av. Colombo 5790, 87020-900, Maringá, Paraná, Brazil. dcbaldoqui@uem.br.
المصدر: Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] [Braz J Microbiol] 2021 Sep; Vol. 52 (3), pp. 1201-1214. Date of Electronic Publication: 2021 Apr 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Springer International Publishing Country of Publication: Brazil NLM ID: 101095924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1678-4405 (Electronic) Linking ISSN: 15178382 NLM ISO Abbreviation: Braz J Microbiol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2019- : Switzerland, AG : Springer International Publishing
Original Publication: Rio de Janeiro, RJ, Brasil : Sociedade Brasileira de Microbiologia
مواضيع طبية MeSH: Chromolaena*/microbiology, Aspergillus flavus/*chemistry , Biological Products/*chemistry, Aflatoxins ; Aspergillus flavus/genetics ; Biological Products/pharmacology ; Endophytes
مستخلص: Endophytes are microorganisms that form symbiotic relationships with their host. These microorganisms can produce a variety of secondary metabolites, some of which have inhibitory effects on pests and pathogens or even act to promote plant growth. Due to these characteristics, these microorganisms are used as sources of biologically active substances for a wide range of biotechnological applications. Based on that, the aim of this study was to evaluate the production of metabolites of the endophytic Aspergillus flavus CL7 isolated from Chromolaena laevigata, in four different cultivation conditions, and to determine the antimicrobial, cytotoxic, antiviral, and antioxidant potential of these extracts. The multiphasic approach used to identify this strain was based on morphology and ITS gene sequence analysis. The chemical investigation of A. flavus using potato dextrose and minimal medium, using both stationary and agitated methods, resulted in the isolation of kojic acid, α-cyclopiazonic acid, and 20,25-dihydroxyaflavinine. Another 18 compounds in these extracts were identified by UHPLC-HRMS/MS, of which dideacetyl parasiticolide A has been described for the first time from A. flavus. Aflatoxins, important chemomarkers of A. flavus, were not detected in any of the extracts, thus indicating that the CL7 strain is non-aflatoxigenic. The biological potential of all extracts was evaluated, and the best results were observed for the extract obtained using minimal medium against Trichophyton rubrum and Mycobacterium tuberculosis.
(© 2021. Sociedade Brasileira de Microbiologia.)
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فهرسة مساهمة: Keywords: Antimicrobial activity; Antiviral activity; Biotechnology; Endophytic fungi; Secondary metabolites
المشرفين على المادة: 0 (Aflatoxins)
0 (Biological Products)
تواريخ الأحداث: Date Created: 20210430 Date Completed: 20211206 Latest Revision: 20231107
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8324641
DOI: 10.1007/s42770-021-00502-6
PMID: 33929720
قاعدة البيانات: MEDLINE
الوصف
تدمد:1678-4405
DOI:10.1007/s42770-021-00502-6