دورية أكاديمية
Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease.
العنوان: | Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease. |
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المؤلفون: | de Sousa IP Jr; Laboratório de Enterovírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. ivanildo.junior@ioc.fiocruz.br., Giamberardino HI; Divisão de Epidemiologia, Hospital Pequeno Príncipe, Curitiba, Brazil., Raboni SM; Laboratório de Virologia, Universidade Federal Do Paraná, Curitiba, Brazil., Debur MC; Laboratório de Saúde Pública, Secretaria de Saúde do Estado do Paraná, Curitiba, Brazil., de Lourdes Aguiar Oliveira M; Laboratório de Vírus Respiratórios e do Sarampo, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Burlandy FM; Laboratório de Enterovírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., da Silva EE; Laboratório de Enterovírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. edson@ioc.fiocruz.br. |
المصدر: | Virology journal [Virol J] 2021 Apr 30; Vol. 18 (1), pp. 88. Date of Electronic Publication: 2021 Apr 30. |
نوع المنشور: | Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: [London] : BioMed Central, 2004- |
مواضيع طبية MeSH: | Enterovirus Infections*/complications , Enterovirus Infections*/diagnosis , Hand, Foot and Mouth Disease*/complications , Hand, Foot and Mouth Disease*/diagnosis , Respiratory Distress Syndrome*/virology , Respiratory Tract Infections*/virology, Child, Preschool ; Enterovirus/genetics ; Enterovirus D, Human ; Fever ; Humans ; Male ; Phylogeny |
مستخلص: | Background: Although most enterovirus (EV) infections can be asymptomatic, these viral agents can cause serious conditions associated with central nervous system, respiratory disease and uncommon manifestations of hand, foot and mouth disease (HFMD). EV-coinfections have been rarely reported with development of complications and severe clinical outcome. An atypical case of a child presenting HFMD and severe acute respiratory syndrome, co-infected with EV-D68 and CVA6, is reported herein. Case Presentation: A 3-year-old boy was admitted in the emergency department unit showing fever, abdominal pain and tachycardia. Twenty-four hours after hospitalization the child developed severe clinical symptoms associated with HFMD and was discharged after recovery. Two days later, the child was readmitted with fever, cough and respiratory distress. RT-PCR and Sanger sequencing confirmed positivity for EV-D68 and CVA6 in oro and nasopharynges swabs and vesicles fluid, respectively. Phylogenetic analysis based on VP1 gene sequences suggested that CVA6 was closely related with HFMD viruses circulating in Turkey, while EV-D68 was genetically related to a Chinese strain. Conclusions: To the best of our knowledge, this case is the first report of a double infection caused by CVA6 and EV-D68, which shed light on the pathogenesis of enterovirus infections. Further studies must be conducted to ascertain the role and clinical significance of EV co-infections, as well as a potential synergistic pathway between these viruses. |
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فهرسة مساهمة: | Keywords: Acute respiratory distress syndrome; CVA6; EV-D68; Enterovirus; Hand, foot and mouth disease |
تواريخ الأحداث: | Date Created: 20210501 Date Completed: 20220222 Latest Revision: 20220222 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8085469 |
DOI: | 10.1186/s12985-021-01560-w |
PMID: | 33931064 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1743-422X |
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DOI: | 10.1186/s12985-021-01560-w |