دورية أكاديمية
أعرض في EDS

Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease.

التفاصيل البيبلوغرافية
العنوان: Simultaneous enterovirus EV-D68 and CVA6 infections causing acute respiratory distress syndrome and hand, foot and mouth disease.
المؤلفون: de Sousa IP Jr; Laboratório de Enterovírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. ivanildo.junior@ioc.fiocruz.br., Giamberardino HI; Divisão de Epidemiologia, Hospital Pequeno Príncipe, Curitiba, Brazil., Raboni SM; Laboratório de Virologia, Universidade Federal Do Paraná, Curitiba, Brazil., Debur MC; Laboratório de Saúde Pública, Secretaria de Saúde do Estado do Paraná, Curitiba, Brazil., de Lourdes Aguiar Oliveira M; Laboratório de Vírus Respiratórios e do Sarampo, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., Burlandy FM; Laboratório de Enterovírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil., da Silva EE; Laboratório de Enterovírus, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil. edson@ioc.fiocruz.br.
المصدر: Virology journal [Virol J] 2021 Apr 30; Vol. 18 (1), pp. 88. Date of Electronic Publication: 2021 Apr 30.
نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2004-
مواضيع طبية MeSH: Enterovirus Infections*/complications , Enterovirus Infections*/diagnosis , Hand, Foot and Mouth Disease*/complications , Hand, Foot and Mouth Disease*/diagnosis , Respiratory Distress Syndrome*/virology , Respiratory Tract Infections*/virology, Child, Preschool ; Enterovirus/genetics ; Enterovirus D, Human ; Fever ; Humans ; Male ; Phylogeny
مستخلص: Background: Although most enterovirus (EV) infections can be asymptomatic, these viral agents can cause serious conditions associated with central nervous system, respiratory disease and uncommon manifestations of hand, foot and mouth disease (HFMD). EV-coinfections have been rarely reported with development of complications and severe clinical outcome. An atypical case of a child presenting HFMD and severe acute respiratory syndrome, co-infected with EV-D68 and CVA6, is reported herein.
Case Presentation: A 3-year-old boy was admitted in the emergency department unit showing fever, abdominal pain and tachycardia. Twenty-four hours after hospitalization the child developed severe clinical symptoms associated with HFMD and was discharged after recovery. Two days later, the child was readmitted with fever, cough and respiratory distress. RT-PCR and Sanger sequencing confirmed positivity for EV-D68 and CVA6 in oro and nasopharynges swabs and vesicles fluid, respectively. Phylogenetic analysis based on VP1 gene sequences suggested that CVA6 was closely related with HFMD viruses circulating in Turkey, while EV-D68 was genetically related to a Chinese strain.
Conclusions: To the best of our knowledge, this case is the first report of a double infection caused by CVA6 and EV-D68, which shed light on the pathogenesis of enterovirus infections. Further studies must be conducted to ascertain the role and clinical significance of EV co-infections, as well as a potential synergistic pathway between these viruses.
References: Lancet Infect Dis. 2014 Jan;14(1):83-86. (PMID: 24287184)
Clin Microbiol Infect. 2019 Feb;25(2):252.e5-252.e8. (PMID: 30149136)
Emerg Microbes Infect. 2015 Oct;4(10):e66. (PMID: 26576342)
Virus Evol. 2018 Oct 01;4(2):vey028. (PMID: 30288300)
J Med Virol. 2020 Aug;92(8):1075-1084. (PMID: 31840822)
Front Public Health. 2018 Apr 09;6:104. (PMID: 29686984)
Genetics. 2002 Jul;161(3):1307-20. (PMID: 12136032)
Arch Virol. 2019 Apr;164(4):1181-1185. (PMID: 30725183)
Virus Evol. 2016 Apr 09;2(1):vew007. (PMID: 27774300)
Mol Biol Evol. 2016 Jul;33(7):1870-4. (PMID: 27004904)
Nucleic Acids Res. 2004 Mar 19;32(5):1792-7. (PMID: 15034147)
Virus Evol. 2018 Jun 08;4(1):vey016. (PMID: 29942656)
Emerg Microbes Infect. 2018 Jan 10;7(1):2. (PMID: 29323107)
Nat Methods. 2012 Jul 30;9(8):772. (PMID: 22847109)
Syst Biol. 2018 Sep 1;67(5):901-904. (PMID: 29718447)
Mol Biol Evol. 2008 Jul;25(7):1459-71. (PMID: 18408232)
J Infect. 2014 Sep;69(3):303-5. (PMID: 24704297)
J Infect. 2018 Nov;77(5):448-454. (PMID: 30149028)
J Clin Virol. 2020 Aug;129:104503. (PMID: 32554306)
BMC Evol Biol. 2007 Nov 08;7:214. (PMID: 17996036)
Clin Infect Dis. 2011 Aug;53(4):400-1. (PMID: 21785005)
Lancet Respir Med. 2015 Nov;3(11):879-87. (PMID: 26482320)
Emerg Microbes Infect. 2020 Dec;9(1):2536-2546. (PMID: 33179584)
J Med Virol. 2013 Jan;85(1):116-20. (PMID: 23124895)
J Clin Microbiol. 1988 Dec;26(12):2576-80. (PMID: 2852672)
Viruses. 2019 Sep 14;11(9):. (PMID: 31540135)
Arch Virol. 2020 Mar;165(3):793-797. (PMID: 31980941)
Bull World Health Organ. 2018 Feb 1;96(2):122-128. (PMID: 29403115)
PLoS Pathog. 2007 Dec;3(12):e191. (PMID: 18085822)
Virology. 2015 Aug;482:28-31. (PMID: 25817402)
J Clin Virol. 2014 Dec;61(4):621-2. (PMID: 25449173)
J Clin Virol. 2019 Jan;110:1-6. (PMID: 30472520)
Lancet Infect Dis. 2016 May;16(5):e64-e75. (PMID: 26929196)
J Clin Microbiol. 2006 Aug;44(8):2698-704. (PMID: 16891480)
Virus Res. 2019 May;265:43-46. (PMID: 30836113)
Annu Rev Pathol. 2019 Jan 24;14:319-338. (PMID: 30355154)
فهرسة مساهمة: Keywords: Acute respiratory distress syndrome; CVA6; EV-D68; Enterovirus; Hand, foot and mouth disease
تواريخ الأحداث: Date Created: 20210501 Date Completed: 20220222 Latest Revision: 20220222
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8085469
DOI: 10.1186/s12985-021-01560-w
PMID: 33931064
قاعدة البيانات: MEDLINE
الوصف
تدمد:1743-422X
DOI:10.1186/s12985-021-01560-w