دورية أكاديمية
Development of BRAF V600E Mutation in NRAS Q61L Mutated Rectal Cancer.
| العنوان: | Development of BRAF V600E Mutation in NRAS Q61L Mutated Rectal Cancer. |
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| المؤلفون: | Cao MN; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos., Chen KT; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos., Li QF; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos., Wang L; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos., Jin GW; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos., Na RT; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos., Ma J; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos., Liu YT; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos., Gao JL; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos golden_bright@hotmail.com.; Laboratory of Molecular Medicine, Ordos Central Hospital, Ordos. |
| المصدر: | Annals of clinical and laboratory science [Ann Clin Lab Sci] 2021 Mar; Vol. 51 (2), pp. 262-266. |
| نوع المنشور: | Case Reports; Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Institute for Clinical Science Country of Publication: United States NLM ID: 0410247 Publication Model: Print Cited Medium: Internet ISSN: 1550-8080 (Electronic) Linking ISSN: 00917370 NLM ISO Abbreviation: Ann Clin Lab Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Philadelphia, Institute for Clinical Science. |
| مواضيع طبية MeSH: | GTP Phosphohydrolases/*genetics , Membrane Proteins/*genetics , Proto-Oncogene Proteins B-raf/*genetics , Rectal Neoplasms/*genetics, DNA Mutational Analysis ; GTP Phosphohydrolases/metabolism ; Humans ; Male ; Membrane Proteins/metabolism ; Middle Aged ; Mutation/genetics ; Proto-Oncogene Proteins B-raf/metabolism ; Signal Transduction |
| مستخلص: | BRAF and NRAS are oncogenes in the RAS/RAF/MEK/MAP-kinase signaling pathway. Coexistent mutations of BRAF and NRAS in a single colorectal cancer patient have always been considered mutually exclusive or at least rare. The clinical outcome of these patients remains undetermined. Herein we report a 53-year-old man harboring an NRAS Q61L mutation in his primary rectal carcinoma, who presented with a concomitant mutation of BRAF V600E in his liver metastasis biopsy 55 months after the primary CRC surgical resection. Our findings suggest that a BRAF and NRAS developed co-mutation may lead to a distinct clinicopathological progression. BRAF-mutated CRCwill not benefit from anti-RAS targeted therapy. (© 2021 by the Association of Clinical Scientists, Inc.) |
| فهرسة مساهمة: | Keywords: BRAF; NRAS; colorectal cancer; concomitant mutation |
| المشرفين على المادة: | 0 (Membrane Proteins) EC 2.7.11.1 (BRAF protein, human) EC 2.7.11.1 (Proto-Oncogene Proteins B-raf) EC 3.6.1.- (GTP Phosphohydrolases) EC 3.6.1.- (NRAS protein, human) |
| تواريخ الأحداث: | Date Created: 20210504 Date Completed: 20210629 Latest Revision: 20210629 |
| رمز التحديث: | 20221213 |
| PMID: | 33941568 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1550-8080 |
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