التفاصيل البيبلوغرافية
| العنوان: |
The Great Deceiver: miR-2392's Hidden Role in Driving SARS-CoV-2 Infection. |
| المؤلفون: |
McDonald JT, Enguita FJ, Taylor D, Griffin RJ, Priebe W, Emmett MR, Sajadi MM, Harris AD, Clement J, Dybas JM, Aykin-Burns N, Guarnieri JW, Singh LN, Grabham P, Baylin SB, Yousey A, Pearson AN, Corry PM, Saravia-Butler A, Aunins TR, Sharma S, Nagpal P, Meydan C, Foox J, Mozsary C, Cerqueira B, Zaksas V, Singh U, Wurtele ES, Costes SV, Davanzo GG, Galeano D, Paccanaro A, Meinig SL, Hagan RS, Bowman NM, Wolfgang MC, Altinok S, Sapoval N, Treangen TJ, Moraes-Vieira PM, Vanderburg C, Wallace DC, Schisler J, Mason CE, Chatterjee A, Meller R, Beheshti A |
| مؤلفون مشاركون: |
UNC COVID-19 Pathobiology Consortium |
| المصدر: |
BioRxiv : the preprint server for biology [bioRxiv] 2021 Aug 18. Date of Electronic Publication: 2021 Aug 18. |
| نوع المنشور: |
Preprint |
| اللغة: |
English |
| بيانات الدورية: |
Country of Publication: United States NLM ID: 101680187 Publication Model: Electronic Cited Medium: Internet NLM ISO Abbreviation: bioRxiv Subsets: PubMed not MEDLINE |
| مستخلص: |
MicroRNAs (miRNAs) are small non-coding RNAs involved in post-transcriptional gene regulation that have a major impact on many diseases and provides an exciting avenue towards antiviral therapeutics. From patient transcriptomic data, we have discovered a circulating miRNA, miR-2392, that is directly involved with SARS-CoV-2 machinery during host infection. Specifically, we show that miR-2392 is key in driving downstream suppression of mitochondrial gene expression, increasing inflammation, glycolysis, and hypoxia as well as promoting many symptoms associated with COVID-19 infection. We demonstrate miR-2392 is present in the blood and urine of COVID-19 positive patients, but not detected in COVID-19 negative patients. These findings indicate the potential for developing a novel, minimally invasive, COVID-19 detection method. Lastly, using in vitro human and in vivo hamster models, we have developed a novel miRNA-based antiviral therapeutic that targets miR-2392, significantly reduces SARS-CoV-2 viability in hamsters and may potentially inhibit a COVID-19 disease state in humans. |
| التعليقات: |
Update in: Cell Rep. 2021 Oct 19;37(3):109839. (PMID: 34624208) |
| معلومات مُعتمدة: |
P20 GM109005 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: |
Date Created: 20210505 Latest Revision: 20220223 |
| رمز التحديث: |
20240628 |
| مُعرف محوري في PubMed: |
PMC8095194 |
| DOI: |
10.1101/2021.04.23.441024 |
| PMID: |
33948587 |
| قاعدة البيانات: |
MEDLINE |
