دورية أكاديمية
Effect of GPIIb-IIIa complex ligands on calcium ion movement and cytoskeleton organization in activated platelets.
| العنوان: | Effect of GPIIb-IIIa complex ligands on calcium ion movement and cytoskeleton organization in activated platelets. |
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| المؤلفون: | Sinigaglia F; Department of Biochemistry, University of Pavia, Italy., Bisio A, Torti M, Balduini CL, Bertolino G, Balduini C |
| المصدر: | Biochemical and biophysical research communications [Biochem Biophys Res Commun] 1988 Jul 15; Vol. 154 (1), pp. 258-64. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 0372516 Publication Model: Print Cited Medium: Print ISSN: 0006-291X (Print) Linking ISSN: 0006291X NLM ISO Abbreviation: Biochem Biophys Res Commun Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2002- >: San Diego, CA : Elsevier Original Publication: New York, Academic Press. |
| مواضيع طبية MeSH: | Blood Platelets/*physiology , Calcium/*blood , Cytoskeleton/*metabolism , Platelet Membrane Glycoproteins/*physiology, Adenosine Diphosphate/pharmacology ; Blood Platelets/drug effects ; Blood Platelets/ultrastructure ; Cytoplasm/metabolism ; Cytoskeleton/ultrastructure ; Fibrinogen/metabolism ; Humans ; Platelet Aggregation ; Thrombin/physiology |
| مستخلص: | We studied the influence of the occupancy of the fibrinogen receptor (GP IIb-IIIa complex) on two early aspects of agonist induced platelet activation: the increase of the intracellular Ca2+ concentration and the cytoskeleton reorganization. A monoclonal antibody, a peptide containing the RGD sequence and fibrinogen purified from human plasma were used as GP IIb-IIIa ligands. The obtained results demonstrated that fibrinogen receptor occupancy inhibits Ca2+ movement and cytoskeleton reorganization caused by low thrombin concentration and ADP. |
| المشرفين على المادة: | 0 (Platelet Membrane Glycoproteins) 61D2G4IYVH (Adenosine Diphosphate) 9001-32-5 (Fibrinogen) EC 3.4.21.5 (Thrombin) SY7Q814VUP (Calcium) |
| تواريخ الأحداث: | Date Created: 19880715 Date Completed: 19880818 Latest Revision: 20190612 |
| رمز التحديث: | 20240513 |
| DOI: | 10.1016/0006-291x(88)90678-x |
| PMID: | 3395329 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0006-291X |
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| DOI: | 10.1016/0006-291x(88)90678-x |