دورية أكاديمية
Identification and quantification of plasticizers, bisphenol, and environmental toxic mineral elements residues in medicines from Tunisian markets.
| العنوان: | Identification and quantification of plasticizers, bisphenol, and environmental toxic mineral elements residues in medicines from Tunisian markets. |
|---|---|
| المؤلفون: | Beltifa A; Research Unit: Analysis and Process Applied on the Environment UR17ES32, ISSAT Mahdia, Rejiche, Tunisia.; Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, University of Messina, Messina, Italy., Alibi S; Research Unit: Analysis and Process Applied on the Environment UR17ES32, ISSAT Mahdia, Rejiche, Tunisia., Turco VL; Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, University of Messina, Messina, Italy., Mansour HB; Research Unit: Analysis and Process Applied on the Environment UR17ES32, ISSAT Mahdia, Rejiche, Tunisia. hdbenmansour@gmail.com., Di Bella G; Dipartimento di Scienze Biomediche, Odontoiatriche e delle Immagini Morfologiche e Funzionali, University of Messina, Messina, Italy. |
| المصدر: | Environmental science and pollution research international [Environ Sci Pollut Res Int] 2021 Sep; Vol. 28 (36), pp. 50462-50470. Date of Electronic Publication: 2021 May 06. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2013->: Berlin : Springer Original Publication: Landsberg, Germany : Ecomed |
| مواضيع طبية MeSH: | Phthalic Acids* , Plasticizers*, Benzhydryl Compounds ; Chromatography, Liquid ; Humans ; Minerals ; Phenols ; Tandem Mass Spectrometry |
| مستخلص: | In this study, 18 plasticizer (phthalates, adipates, sebacates, and others) residues in sixteen medicines available in Tunisian pharmaceutical markets are evaluated by MSPD combined with GC-MS. In parallel, in this research, UPLC-MS/MS technique was performed to detect bisphenol A, and cadmium, lead, chromium, cobalt, nickel, mercury, selenium, and arsenic levels were determined by ICP-MS. The maximum daily ingested mass of mineral elements was calculated and compared with permissible daily exposure limits published by USP NF 2013. Our results demonstrated that the 50% of drugs contained similar concentrations of di-ethyl adipate. Di-isobutyl phthalate was found in a single sample with a high concentration (1.07mgkg -1 ). Di-methyladipate was also present in only one sample. Diethyl phthalate was detected in three medicines: the highest concentration (17.03mgkg -1 ) was found in capsules. The other plasticizers and bisphenol A levels were below the limits of quantification in the all samples. All tested products were safe for use, except two clay-originated products. Concentrations and the maximum daily ingested mass of lead and arsenic were higher than recommended limits. The use of these medicines should require more attention taking into account the serious hazards of heavy metals to human health. (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
| References: | Arora M, Kiran B, Rania S, Rani A, Kaur B, Mittala N (2008) Heavy metal accumulation in vegetables irrigated with water from different sources. Food Chem 111(4):811–815. (PMID: 10.1016/j.foodchem.2008.04.049) Beltifa A, Feriani A, Machreki M, Ghorbel A, Ghazouani L, Di Bella VLJ, Reyns T, Mansour HB (2017) Plasticizers and bisphenol A, in packaged foods sold in the Tunisian markets: study of their acute in vivo toxicity and their environmental fate. Environ Sci Pollut Res 24(28):22382–22392. (PMID: 10.1007/s11356-017-9861-0) Beltifa A, Belaid A, Lo Turco V, Machreki M, Ben Mansour H, Di Bella G (2018a) Preliminary evaluation of plasticizer and BPA in Tunisian cosmetics and investigation of hazards on human skin cells. J Environ Health Res 28(5):491–501. (PMID: 10.1080/09603123.2018.1489528) Beltifa A, Feriani A, Macherki M, Ghorbel A, Ghazouani L, Di Bella G, Sire O, Van Loco J, Reyns T, Mansour HB (2018b) Persistent plasticizers and bisphenol in the cheese of Tunisian markets induced biochemical and histopathological alterations in male BALB/c mice. Environ Sci Pollut Res 25(7):6545–6557. (PMID: 10.1007/s11356-017-0857-6) Campbell I (2010) Trace element analysis of heavy metals in pharmaceutical materials. Spectroscopy. Celeiro M, Guerra E, Lamas JP, Lores M, Garcia-Jares C, Llompart M (2014) Development of a multianalyte method based on micro-matrix-solid-phase dispersion for the analysis of fragrance allergens and preservatives in personal care products. J Chromatogr A 1344:1–14. (PMID: 10.1016/j.chroma.2014.03.070) Chebbi M, Beltifa A, Alibi S, Di Bella G, Loturco V, Sire O, Ben Mansour H, Le Tilly V (2020) Estrogenic hazards of short chain phthalates and bisphenols found in cosmetic products. Int J Environ Health Res 1-12. Chen SJ, Yan XJ, Chen Z (2013) Arsenic in therapy. Encycl Metalloproteins. https://doi.org/10.1007/978-1-4614-1533-6_492. De Toni L, Tisato F, Seraglia R, Roverso M, Gandin V, Marzano C, Padrini R, Foresta C (2017) Phthalates and heavy metals as endocrine disruptors in food: a study on pre-packed coffee products. Toxicol Rep 4:234–239. (PMID: 10.1016/j.toxrep.2017.05.004) Di Bella G, Ben Mansour H, Ben Tekaya A, Beltifa A, Potortì AG, Saiya E, Bartolomeo G, Dugo G, Lo Turco V (2018) Plasticizers and BPA residues in Tunisian and Italian culinary herbs and spices. J Food Sci 83(6):1769–1774. (PMID: 10.1111/1750-3841.14171) Dyer CA (2007) Heavy metals as endocrine-disrupting chemicals. Endocrine-disrupting chemicals. Contemporary Endocrinology. Humana Press 111-133. Eurachem/CITAC Guide (2000) Quantifying uncertainty in analytical measurement, 2. edition 2000, Published by LGC, UK (see www.eurachem.org ). Fankhauser NA, Grob K (2007) Blank problems in trace analysis of diethylhexyl and dibutyl phthalate: investigation of the sources, tips and tricks. Anal Chim Acta 23(2):353–360. (PMID: 10.1016/j.aca.2006.09.012) Iavicoli I, Fontana L, Bergamaschi A (2009) The effects of metals as endocrine disruptors. J Toxicol Environ Health B Crit Rev 12(3):206–223. (PMID: 10.1080/10937400902902062) Jaishankar M, Tseten T, Anbalagan N, Mathew BB, Beeregowda KN (2014) Toxicity, mechanism and health effects of some heavy metals. Interdiscip Toxicol 7(2):60–72. (PMID: 10.2478/intox-2014-0009) Leyssens L, Vinck B, Van Der Straeten C, Wuyts F, Maes L (2017) Cobalt toxicity in humans—a review of the potential sources and systemic health effects. Toxicology 387(17):43–56. (PMID: 10.1016/j.tox.2017.05.015) Li X, Qian P (2017) Identification of an exposure risk to heavy metals from pharmaceutical-grade rubber stoppers. J Food Drug Anal 25(3):723–730. (PMID: 10.1016/j.jfda.2016.07.008) Lo Turco V, Di Bella G, Potortì AG, Tropea A, Casale EK, Fede MR, Dugo G (2016) Determination of plasticisers and BPA in Sicilian and Calabrian nectar honeys by selected ion monitoring GC/MS. Food Addit Contam Part A Chem Anal Control Expo Risk Assess 33(11):1693–1699. (PMID: 10.1080/19440049.2016.1239030) MacFarquhar JK, Broussard DL, Melstrom P, Hutchinson R, Wolkin A, Martin C, Burk RF, Dunn JR, Green LA, Hammond R, Schaffner W, Jones TF (2010) Acute selenium toxicity associated with a dietary supplement. Arch Intern Med 170(3):256–261. (PMID: 10.1001/archinternmed.2009.495) Mathieu-Denoncourt J, Wallace SJ, de Solla SR, Langlois VS (2015) Plasticizer endocrine disruption: highlighting developmental and reproductive effects in mammals and non-mammalian aquatic species. Gen Comp Endocrinol 219:74–88. (PMID: 10.1016/j.ygcen.2014.11.003) Nessa F, Khan SA, Abu Shawish KY (2016) Lead, cadmium and nickel contents of some medicinal agents. Indian J Pharm Sci 78(1):111–119. (PMID: 10.4103/0250-474X.180260) Orazizadeh M, Khodadadi A, Bayati V, Saremy S, Farasat M, Khorsandi L (2015) In vitro toxic effects of zinc oxide nanoparticles on rat adipose tissue-derived mesenchymal stem cells. Cell J 17(3):412–421. Pereira C, Mapuskar K, Rao CV (2006) Chronic toxicity of diethyl phthalate in male Wistar rats—a dose–response study. Regul Toxicol Pharmacol 45(2):169–177. (PMID: 10.1016/j.yrtph.2006.04.006) Raghuram P, Soma Raju IV, Sriramulu J (2010) Heavy metals testing in active pharmaceutical ingredients: an alternate approach. Pharmazie 65(1):15–18. Reddy MM, Reddy KH, Reddy MU (2016) Harmonized guideline on limit and testing of elemental impurities in pharmaceutical substances: a review. Pharm Reg Affairs 5:2. Reichert U, Sehat N (2013) Merck Millipore metal residue: how much is too much? 2013. Available from: http://www.pharmamanufacturing.com/articles/2013/1308-metal-residue/ . Accessed 2020. Saillenfait AM, Sabaté JP, Gallissot F (2006) Developmental toxic effects of diisobutyl phthalate, the methyl-branched analogue of di-n-butyl phthalate, administered by gavage to rats. Toxicol Lett 165(1):39–46. (PMID: 10.1016/j.toxlet.2006.01.013) Singh AR, Lawrence WH, Autian J (1973) Embryonic-fetal toxicity and teratogenic effects of adipic acid esters in rats. J Pharm Sci 62(10):1596–1600. (PMID: 10.1002/jps.2600621004) Stewart FN, Strode CW Jr (1952) Determination of heavy metals in pharmaceutical chemicals. J Am Pharm Assoc 41(5):242–251. (PMID: 10.1002/jps.3030410506) Trela BA, Frame SR, Bogdanffy MS (1992) A microscopic and ultrastructural evaluation of dibasic esters (DBE) toxicity in rat nasal explants. Exp Mol Pathol 56(3):208–218. (PMID: 10.1016/0014-4800(92)90037-C) Trombetta D, Mondello MR, Cimino F, Cristani M, Pergolizzi S, Saija A (2005) Toxic effect of nickel in an in vitro model of human oral epithelium. Toxicol Lett 59(3):219–225. (PMID: 10.1016/j.toxlet.2005.05.019) United States Pharmacopeia (USP) (2013) pp 1–33 ( https://www.usp.org/ ). Accessed 2020. |
| فهرسة مساهمة: | Keywords: Bisphenol A; Contaminants; Migration; Pharmaceutical residues; Plasticizers; Toxic mineral elements |
| المشرفين على المادة: | 0 (Benzhydryl Compounds) 0 (Minerals) 0 (Phenols) 0 (Phthalic Acids) 0 (Plasticizers) MLT3645I99 (bisphenol A) |
| تواريخ الأحداث: | Date Created: 20210506 Date Completed: 20210920 Latest Revision: 20210920 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1007/s11356-021-14221-w |
| PMID: | 33956323 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 1614-7499 |
|---|---|
| DOI: | 10.1007/s11356-021-14221-w |