دورية أكاديمية
Sex chromosome transformation and the origin of a male-specific X chromosome in the creeping vole.
| العنوان: | Sex chromosome transformation and the origin of a male-specific X chromosome in the creeping vole. |
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| المؤلفون: | Couger MB; Department of Thoracic Surgery, Brigham and Women's Hospital, Boston MA, 02115, USA., Roy SW; Department of Biology, San Francisco State University, San Francisco, CA 94117, USA.; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA 95343, USA., Anderson N; Department of Molecular and Cell Biology, University of California, Merced, Merced, CA 95343, USA., Gozashti L; Department of Organismic and Evolutionary Biology and Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, USA., Pirro S; Iridian Genomes, Inc., Bethesda, MD 20817, USA., Millward LS; Department of Fisheries and Wildlife, Oregon State University, Corvallis, OR 97330, USA., Kim M; Circulomics Inc., Baltimore, MD 21202, USA., Kilburn D; Circulomics Inc., Baltimore, MD 21202, USA., Liu KJ; Circulomics Inc., Baltimore, MD 21202, USA., Wilson TM; US Forest Service, PNW Research Station, Corvallis, OR 97331, USA., Epps CW; Department of Fisheries and Wildlife, Oregon State University, Corvallis, OR 97330, USA., Dizney L; Department of Biology, University of Portland, Portland, OR 97203, USA., Ruedas LA; Department of Biology and Museum of Natural History, Portland State University, Portland, OR 97207, USA., Campbell P; Department of Evolution, Ecology, and Organismal Biology, University of California, Riverside, Riverside, CA 92521, USA. polly.campbell@ucr.edu. |
| المصدر: | Science (New York, N.Y.) [Science] 2021 May 07; Vol. 372 (6542), pp. 592-600. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Association for the Advancement of Science Country of Publication: United States NLM ID: 0404511 Publication Model: Print Cited Medium: Internet ISSN: 1095-9203 (Electronic) Linking ISSN: 00368075 NLM ISO Abbreviation: Science Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Original Publication: New York, N.Y. : [s.n.] 1880- |
| مواضيع طبية MeSH: | Abnormal Karyotype*, Arvicolinae/*genetics , Sex Determination Processes/*genetics , X Chromosome/*genetics, Animals ; Base Sequence ; Female ; Gene Amplification ; Genes, sry ; Haplotypes ; Male ; Maternal Inheritance ; X Chromosome Inactivation ; Y Chromosome/genetics |
| مستخلص: | The mammalian sex chromosome system (XX female/XY male) is ancient and highly conserved. The sex chromosome karyotype of the creeping vole ( Microtus oregoni ) represents a long-standing anomaly, with an X chromosome that is unpaired in females (X0) and exclusively maternally transmitted. We produced a highly contiguous male genome assembly, together with short-read genomes and transcriptomes for both sexes. We show that M. oregoni has lost an independently segregating Y chromosome and that the male-specific sex chromosome is a second X chromosome that is largely homologous to the maternally transmitted X. Both maternally inherited and male-specific sex chromosomes carry fragments of the ancestral Y chromosome. Consequences of this recently transformed sex chromosome system include Y-like degeneration and gene amplification on the male-specific X, expression of ancestral Y-linked genes in females, and X inactivation of the male-specific chromosome in male somatic cells. The genome of M. oregoni elucidates the processes that shape the gene content and dosage of mammalian sex chromosomes and exemplifies a rare case of plasticity in an ancient sex chromosome system. (Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.) |
| معلومات مُعتمدة: | R44 GM134994 United States GM NIGMS NIH HHS |
| تواريخ الأحداث: | Date Created: 20210507 Date Completed: 20210514 Latest Revision: 20220131 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1126/science.abg7019 |
| PMID: | 33958470 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1095-9203 |
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| DOI: | 10.1126/science.abg7019 |