دورية أكاديمية

The role of profilin-1 in cardiovascular diseases.

التفاصيل البيبلوغرافية
العنوان: The role of profilin-1 in cardiovascular diseases.
المؤلفون: Allen A; Bioengineering, University of Pittsburgh., Gau D; Bioengineering, University of Pittsburgh., Roy P; Bioengineering, University of Pittsburgh.; Pathology, University of Pittsburgh, 306 Center for Bioengineering, University of Pittsburgh, 300 Technology Drive, Pittsburgh, PA 15219, USA.
المصدر: Journal of cell science [J Cell Sci] 2021 May 01; Vol. 134 (9). Date of Electronic Publication: 2021 May 07.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review
اللغة: English
بيانات الدورية: Publisher: Company of Biologists Country of Publication: England NLM ID: 0052457 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1477-9137 (Electronic) Linking ISSN: 00219533 NLM ISO Abbreviation: J Cell Sci Subsets: MEDLINE
أسماء مطبوعة: Publication: Cambridge : Company of Biologists
Original Publication: London.
مواضيع طبية MeSH: Cardiovascular Diseases*/genetics , Profilins*/genetics, Actin Cytoskeleton/genetics ; Actins/genetics ; Humans ; Microfilament Proteins
مستخلص: Dynamic remodeling of the actin cytoskeleton is an essential feature for virtually all actin-dependent cellular processes, including cell migration, cell cycle progression, chromatin remodeling and gene expression, and even the DNA damage response. An altered actin cytoskeleton is a structural hallmark associated with numerous pathologies ranging from cardiovascular diseases to immune disorders, neurological diseases and cancer. The actin cytoskeleton in cells is regulated through the orchestrated actions of a myriad of actin-binding proteins. In this Review, we provide a brief overview of the structure and functions of the actin-monomer-binding protein profilin-1 (Pfn1) and then discuss how dysregulated expression of Pfn1 contributes to diseases associated with the cardiovascular system.
Competing Interests: Competing interests The authors declare no competing or financial interests.
(© 2021. Published by The Company of Biologists Ltd.)
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معلومات مُعتمدة: T32 HL129964 United States HL NHLBI NIH HHS; F31 HL160118 United States HL NHLBI NIH HHS; T32 HL076124 United States HL NHLBI NIH HHS; R01 CA248873 United States CA NCI NIH HHS; R01 CA108607 United States CA NCI NIH HHS
فهرسة مساهمة: Keywords: Actin; Atherosclerosis; Diabetes; Hypertension; Profilin
المشرفين على المادة: 0 (Actins)
0 (Microfilament Proteins)
0 (Profilins)
تواريخ الأحداث: Date Created: 20210507 Date Completed: 20210712 Latest Revision: 20220816
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8126447
DOI: 10.1242/jcs.249060
PMID: 33961053
قاعدة البيانات: MEDLINE
الوصف
تدمد:1477-9137
DOI:10.1242/jcs.249060