دورية أكاديمية
أعرض في EDS

The Emerging Role of Viability Testing During Liver Machine Perfusion.

التفاصيل البيبلوغرافية
العنوان: The Emerging Role of Viability Testing During Liver Machine Perfusion.
المؤلفون: Brüggenwirth IMA; Department of SurgerySection of Hepato-Pancreato-Biliary Surgery and Liver Transplantation University Medical Center GroningenUniversity of Groningen Groningen the Netherlands Division of Organ TransplantationDepartment of Surgery UMass Memorial Medical CenterUniversity of Massachusetts Worcester MA., van Leeuwen OB, Porte RJ, Martins PN
المصدر: Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society [Liver Transpl] 2022 May; Vol. 28 (5), pp. 876-886. Date of Electronic Publication: 2021 Jun 24.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Wolters Kluwer Health, Inc Country of Publication: United States NLM ID: 100909185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1527-6473 (Electronic) Linking ISSN: 15276465 NLM ISO Abbreviation: Liver Transpl Subsets: MEDLINE
أسماء مطبوعة: Publication: 2023- : [Philadelphia] : Wolters Kluwer Health, Inc.
Original Publication: Philadelphia, PA : W.B. Saunders Co., c2000-
مواضيع طبية MeSH: Liver Transplantation*/adverse effects , Organ Preservation*/adverse effects, Humans ; Liver/metabolism ; Liver/surgery ; Perfusion/adverse effects ; Tissue Donors
مستخلص: The transplant community continues to be challenged by the disparity between the need for liver transplantation and the shortage of suitable donor organs. At the same time, the number of unused donor livers continues to increase, most likely attributed to the worsening quality of these organs. To date, there is no reliable marker of liver graft viability that can predict good posttransplant outcomes. Ex situ machine perfusion offers additional data to assess the viability of donor livers before transplantation. Hence, livers initially considered unsuitable for transplantation can be assessed during machine perfusion in terms of appearance and consistency, hemodynamics, and metabolic and excretory function. In addition, postoperative complications such as primary nonfunction or posttransplant cholangiopathy may be predicted and avoided. A variety of viability criteria have been used in machine perfusion, and to date there is no widely accepted composition of criteria for clinical use. This review discusses potential viability markers for hepatobiliary function during machine perfusion, describes current limitations, and provides future recommendations for the use of viability criteria in clinical liver transplantation.
(Copyright © 2021 by the American Association for the Study of Liver Diseases.)
التعليقات: Comment in: Liver Transpl. 2022 May;28(5):751-753. (PMID: 35092160)
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تواريخ الأحداث: Date Created: 20210508 Date Completed: 20220420 Latest Revision: 20230509
رمز التحديث: 20230509
DOI: 10.1002/lt.26092
PMID: 33963657
قاعدة البيانات: MEDLINE
الوصف
تدمد:1527-6473
DOI:10.1002/lt.26092