دورية أكاديمية
Long-term adult congenital heart disease survival after heart transplantation: A restricted mean survival time analysis.
| العنوان: | Long-term adult congenital heart disease survival after heart transplantation: A restricted mean survival time analysis. |
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| المؤلفون: | Dolgner SJ; Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle Washington. Electronic address: sdolgner@gmail.com., Nguyen VP; Providence St. Vincent's Medical Center, Heart Institute, Seattle Washington., Krieger EV; Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle Washington., Stempien-Otero A; Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle Washington., Dardas TF; Department of Medicine, Division of Cardiology, University of Washington School of Medicine, Seattle Washington. |
| المصدر: | The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation [J Heart Lung Transplant] 2021 Jul; Vol. 40 (7), pp. 698-706. Date of Electronic Publication: 2021 Mar 13. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 9102703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1557-3117 (Electronic) Linking ISSN: 10532498 NLM ISO Abbreviation: J Heart Lung Transplant Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 1999- : New York, NY : Elsevier Original Publication: St. Louis, Mo. : Mosby-Year Book, Inc., c1991- |
| مواضيع طبية MeSH: | Heart Defects, Congenital/*surgery , Heart Transplantation/*mortality , Tissue Donors/*statistics & numerical data, Adult ; Databases, Factual ; Female ; Follow-Up Studies ; Heart Defects, Congenital/mortality ; Humans ; Male ; Middle Aged ; Retrospective Studies ; Survival Rate/trends ; Time Factors ; United States/epidemiology |
| مستخلص: | Background: Adult Congenital Heart Disease (ACHD) heart transplant recipients may have lower post-transplant survival resulting from higher peri-operative mortality than non-ACHD patients. However, the late risk of mortality appears lower in ACHD recipients. This study seeks to establish whether long-term heart transplant survival is reduced among ACHD recipients relative to non-ACHD recipients. Methods: Adult patients who received a heart transplant between January, 2000 and December, 2019 in the United Network for Organ Sharing database were stratified by the presence of ACHD. Propensity-matched cohorts (1:4) were created to adjust for differences between groups. Graft survival at time points from 1 to 18 years was compared between groups using restricted mean survival time (RMST) analysis. Results: The matched cohort included 1,139 ACHD and 4,293 non-ACHD patients. Median age was 35 years and 61% were male. Average survival time at 1 year was 0.85 years for ACHD patients and 0.93 years for non-ACHD patients (average difference: -0.08 years, 95% Confidence Interval [CI] -0.10 to -0.06, p < 0.001), reflecting higher immediate post-transplant mortality. Average survival time at 18 years was not clinically or statistically different: 11.14 years for ACHD patients and 11.40 years for non-ACHD patients (average difference: -0.26 years, 95% CI: -0.85 to + 0.32 years, p = 0.38). Conclusions: Despite increased medium-term mortality among ACHD patients after heart transplant, differences in long-term survival are minimal. Allocation of hearts to ACHD patients results in acceptable utility of donor hearts. (Copyright © 2021 International Society for Heart and Lung Transplantation. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: UNOS; adult congenital heart disease; congenital heart disease; heart transplant; non-proportional risks; outcomes |
| تواريخ الأحداث: | Date Created: 20210509 Date Completed: 20220131 Latest Revision: 20220131 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.healun.2021.02.019 |
| PMID: | 33965332 |
| قاعدة البيانات: | MEDLINE |
Full Text via ClinicalKey 
Full Text Finder | تدمد: | 1557-3117 |
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| DOI: | 10.1016/j.healun.2021.02.019 |