دورية أكاديمية
Extracellular miRNAs in redox signaling: Health, disease and potential therapies.
| العنوان: | Extracellular miRNAs in redox signaling: Health, disease and potential therapies. |
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| المؤلفون: | Ruiz GP; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Camara H; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Fazolini NPB; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil., Mori MA; Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Campinas, SP, Brazil; Experimental Medicine Research Cluster (EMRC), University of Campinas, Campinas, SP, Brazil; Obesity and Comorbidities Research Center (OCRC), University of Campinas, Campinas, SP, Brazil. Electronic address: morima@unicamp.br. |
| المصدر: | Free radical biology & medicine [Free Radic Biol Med] 2021 Sep; Vol. 173, pp. 170-187. Date of Electronic Publication: 2021 May 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: United States NLM ID: 8709159 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-4596 (Electronic) Linking ISSN: 08915849 NLM ISO Abbreviation: Free Radic Biol Med Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Tarrytown, NY : Elsevier Science Original Publication: New York : Pergamon, c1987- |
| مواضيع طبية MeSH: | Diabetes Mellitus, Type 2*/metabolism , Exosomes*/metabolism , MicroRNAs*/genetics , MicroRNAs*/metabolism, Humans ; Oxidation-Reduction ; Signal Transduction |
| مستخلص: | Extracellular microRNAs (miRNAs) have emerged as important mediators of cell-to-cell communication and intertissue crosstalk. MiRNAs are produced by virtually all types of eukaryotic cells and can be selectively packaged and released to the extracellular medium, where they may reach distal cells to regulate gene expression cell non-autonomously. By doing so, miRNAs participate in integrative physiology. Oxidative stress affects miRNA expression, while miRNAs control redox signaling. Disruption in miRNA expression, processing or release to the extracellular compartment are associated with aging and a number of chronic diseases, such as obesity, type 2 diabetes, neurodegenerative diseases and cancer, all of them being conditions related to oxidative stress. Here we discuss the interplay between redox balance and miRNA function and secretion as a determinant of health and disease states, reviewing the findings that support this notion and highlighting novel and yet understudied venues of research in the field. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Aging; Cancer; Cardiovascular disease; Exosomes; Extracellular vesicles; Metabolic syndrome; Neurodegenerative diseases; Oxidative stress; RNA therapeutics; Redox biology; miRNA |
| المشرفين على المادة: | 0 (MicroRNAs) |
| تواريخ الأحداث: | Date Created: 20210509 Date Completed: 20210902 Latest Revision: 20210902 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.freeradbiomed.2021.05.004 |
| PMID: | 33965563 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1873-4596 |
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| DOI: | 10.1016/j.freeradbiomed.2021.05.004 |