دورية أكاديمية
أعرض في EDS

Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study.

التفاصيل البيبلوغرافية
العنوان: Systemic inflammation is negatively associated with early post discharge growth following acute illness among severely malnourished children - a pilot study.
المؤلفون: Njunge JM; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Gonzales GB; Department of Internal Medicine and Pediatrics, Faculty of Medicine and Health Sciences, Ghent University, Ghent, Belgium., Ngari MM; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Thitiri J; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya., Bandsma RHJ; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; Centre for Global Child Health, The Hospital for Sick Children, Toronto, Ontario, Canada., Berkley JA; The Childhood Acute Illness & Nutrition (CHAIN) Network, Nairobi, Kenya.; KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.; Centre for Tropical Medicine & Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
المصدر: Wellcome open research [Wellcome Open Res] 2021 Mar 16; Vol. 5, pp. 248. Date of Electronic Publication: 2021 Mar 16 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Wellcome Trust Country of Publication: England NLM ID: 101696457 Publication Model: eCollection Cited Medium: Print ISSN: 2398-502X (Print) Linking ISSN: 2398502X NLM ISO Abbreviation: Wellcome Open Res Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [London] : Wellcome Trust, [2016]-
مستخلص: Background: Rapid growth should occur among children with severe malnutrition (SM) with medical and nutritional management. Systemic inflammation (SI) is associated with death among children with SM and is negatively associated with linear growth. However, the relationship between SI and weight gain during therapeutic feeding following acute illness is unknown. We hypothesised that growth post-hospital discharge is associated with SI among children with SM. Methods: We conducted secondary analysis of data from HIV-uninfected children with SM (n=98) who survived and were not readmitted to hospital during one year of follow-up. We examined the relationship between changes in absolute deficits in weight and mid-upper-arm circumference (MUAC) from enrolment at stabilisation to 60 days and one year later, and untargeted plasma proteome, targeted cytokines/chemokines, leptin, and soluble CD14 using multivariate regularized linear regression. Results: The mean change in absolute deficit in weight and MUAC was -0.50kg (standard deviation; SD±0.69) and -1.20cm (SD±0.89), respectively, from enrolment to 60 days later. During the same period, mean weight and MUAC gain was 3.3g/kg/day (SD±2.4) and 0.22mm/day (SD±0.2), respectively. Enrolment interleukins; IL17-alpha and IL-2, and serum amyloid P were negatively associated with weight and MUAC gain during 60 days. Lipopolysaccharide binding protein and complement component 2 were negatively associated with weight gain only. Leptin was positively associated with weight gain. Soluble CD14, beta-2 microglobulin, and macrophage inflammatory protein 1 beta were negatively associated with MUAC gain only. Glutathione peroxidase 3 was positively associated with weight and MUAC gain during one year. Conclusions: Early post-hospital discharge weight and MUAC gain were rapid and comparable to children with uncomplicated SM treated in the community. Higher concentrations of SI markers were associated with less weight and MUAC gain, suggesting inflammation negatively impacts recovery from wasting. This finding warrants further research on reducing inflammation on growth among children with SM.
Competing Interests: No competing interests were disclosed.
(Copyright: © 2021 Njunge JM et al.)
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معلومات مُعتمدة: United Kingdom WT_ Wellcome Trust; MR/M007367/1 United Kingdom MRC_ Medical Research Council
فهرسة مساهمة: Keywords: anthropometric deficit; child growth; cytokines; inflammation; mid-upper arm circumference; proteome; severe malnutrition; weight
تواريخ الأحداث: Date Created: 20210512 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC8080977
DOI: 10.12688/wellcomeopenres.16330.2
PMID: 33969227.2. Version: 2. Publisher Version ID: 2. Version Date: 2021/03/16
قاعدة البيانات: MEDLINE
الوصف
تدمد:2398-502X
DOI:10.12688/wellcomeopenres.16330.2