دورية أكاديمية
أعرض في EDS

Antimicrobial susceptibility testing results from 13 hospitals in Viet Nam: VINARES 2016-2017.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial susceptibility testing results from 13 hospitals in Viet Nam: VINARES 2016-2017.
المؤلفون: Vu TVD; Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam. dungvtv@oucru.org., Choisy M; Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK., Do TTN; Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam., Nguyen VMH; Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam., Campbell JI; Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam., Le TH; National Hospital for Tropical Diseases, Hanoi, Viet Nam., Nguyen VT; National Hospital for Tropical Diseases, Hanoi, Viet Nam., Wertheim HFL; Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam.; Department of Medical Microbiology, Radboudumc Center for Infectious Diseases, Radboudumc, Nijmegen, Netherlands., Pham NT; National Hospital for Tropical Diseases, Hanoi, Viet Nam., Nguyen VK; National Hospital for Tropical Diseases, Hanoi, Viet Nam., van Doorn HR; Oxford University Clinical Research Unit, National Hospital for Tropical Diseases, 78 Giai Phong, Dong Da, Hanoi, Viet Nam.; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
مؤلفون مشاركون: VINARES consortium
المصدر: Antimicrobial resistance and infection control [Antimicrob Resist Infect Control] 2021 May 10; Vol. 10 (1), pp. 78. Date of Electronic Publication: 2021 May 10.
نوع المنشور: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101585411 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-2994 (Electronic) Linking ISSN: 20472994 NLM ISO Abbreviation: Antimicrob Resist Infect Control Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مواضيع طبية MeSH: Drug Resistance, Bacterial* , Microbial Sensitivity Tests*, Anti-Bacterial Agents/*pharmacology, Gram-Negative Bacteria/drug effects ; Gram-Positive Bacteria/drug effects ; Hospitals ; Humans ; Vietnam
مستخلص: Objective: To analyse data from 2016-17 from a hospital-based antimicrobial resistance surveillance with national coverage in a network of hospitals Viet Nam.
Methods: We analysed data from 13 hospitals, 3 less than the dataset from the 2012-13 period. Identification and antimicrobial susceptibility testing data from the clinical microbiology laboratories from samples sent in for routine diagnostics were used. Clinical and Laboratory Standards Institute 2018 guidelines were used for antimicrobial susceptibility testing interpretation. WHONET was used for data entry, management and analysis.
Results: 42,553 deduplicated isolates were included in this analysis; including 30,222 (71%) Gram-negative and 12,331 (29%) Gram-positive bacteria. 8,793 (21%) were from ICUs and 7,439 (18%) isolates were from invasive infections. Escherichia coli and Staphylococcus aureus were the most frequently detected species with 9,092 (21%) and 4,833 isolates (11%), respectively; followed by Klebsiella pneumoniae (3,858 isolates - 9.1%) and Acinetobacter baumannii (3,870 isolates - 9%). Bacteria were mainly isolated from sputum (8,798 isolates - 21%), blood (7,118 isolates - 17%) and urine (5,202 isolates - 12%). Among Gram-positives 3,302/4,515 isolates (73%) of S. aureus were MRSA; 99/290 (34%) of Enterococcus faecium were resistant to vancomycin; and 58% (663/1,136) of Streptococcus pneumoniae proportion were reduced susceptible to penicillin. Among Gram-negatives 59% (4,085/6,953) and 40% (1,186/2,958) of E. coli and K. pneumoniae produced ESBL and 29% (376/1,298) and 11% (961/8,830) were resistant to carbapenems, respectively. 79% (2855/3622) and 45% (1,514/3,376) of Acinetobacter spp. and Pseudomonas aeruginosa were carbapenem resistant, respectively. 88% (804/911) of Haemophilus influenzae were ampicillin resistant and 18/253 (7%) of Salmonella spp. and 7/46 (15%) of Shigella spp. were resistant to fluoroquinolones. The number of isolates from which data were submitted in the 2016-2017 period was twice as high as in 2012-2013. AMR proportions were higher in 2016-2017 for most pathogen-antimicrobial combinations of interest including imipenem-resistant A. baumannii, P. aeruginosa and Enterobacterales.
Conclusions: The data show alarmingly high and increasing resistant proportions among important organisms in Viet Nam. AMR proportions varied across hospital types and should be interpreted with caution because existing sampling bias and missing information on whether isolates were community or hospital acquired. Affordable and scalable ways to adopt a sample- or case-based approach across the network should be explored and clinical data should be integrated to help provide more accurate inferences of the surveillance data.
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معلومات مُعتمدة: T32 HS000063 United States HS AHRQ HHS
فهرسة مساهمة: Keywords: Antimicrobial resistance; Surveillance; VINARES; Viet Nam
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20210511 Date Completed: 20211216 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC8112055
DOI: 10.1186/s13756-021-00937-4
PMID: 33971969
قاعدة البيانات: MEDLINE
الوصف
تدمد:2047-2994
DOI:10.1186/s13756-021-00937-4