دورية أكاديمية
أعرض في EDS

Immune and barrier characterization of atopic dermatitis skin phenotype in Tanzanian patients.

التفاصيل البيبلوغرافية
العنوان: Immune and barrier characterization of atopic dermatitis skin phenotype in Tanzanian patients.
المؤلفون: Lang CCV; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Dermatology, University Hospital Zürich, Zürich, Switzerland., Renert-Yuval Y; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York., Del Duca E; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Dermatology, University of Magna Graecia, Catanzaro, Italy., Pavel AB; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York; Department of Biomedical Engineering, University of Mississippi, Oxford, Mississippi., Wu J; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York., Zhang N; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York., Dubin C; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York., Obi A; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York., Chowdhoury M; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York., Kim M; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York., Estrada YD; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York., Krueger JG; Laboratory for Investigative Dermatology, The Rockefeller University, New York, New York., Kaderbhai H; Department of Dermatology, M.P. Shah Hospital, Nairobi, Kenya; Department of Dermatology, Regional Dermatology Training Center, Moshi, Tanzania., Semango G; Department of Dermatology, Regional Dermatology Training Center, Moshi, Tanzania., Schmid-Grendelmeier P; Department of Dermatology, University Hospital Zürich, Zürich, Switzerland., Brüggen MC; Department of Dermatology, University Hospital Zürich, Zürich, Switzerland; Hochgebirgsklinik Davos, Davos, Switzerland., Masenga JE; Department of Dermatology, Regional Dermatology Training Center, Moshi, Tanzania., Guttman-Yassky E; Laboratory of Inflammatory Skin Diseases, Department of Dermatology, Icahn School of Medicine at Mount Sinai, New York, New York. Electronic address: Emma.Guttman@mountsinai.org.
المصدر: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology [Ann Allergy Asthma Immunol] 2021 Sep; Vol. 127 (3), pp. 334-341. Date of Electronic Publication: 2021 May 09.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: American College of Allergy, Asthma, and Immunology Country of Publication: United States NLM ID: 9503580 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1534-4436 (Electronic) Linking ISSN: 10811206 NLM ISO Abbreviation: Ann Allergy Asthma Immunol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: McLean, VA : American College of Allergy, Asthma, and Immunology
مواضيع طبية MeSH: Dermatitis, Atopic/*immunology , Skin/*immunology, Adult ; Black People/genetics ; Cytokines/immunology ; Dermatitis, Atopic/ethnology ; Dermatitis, Atopic/genetics ; Female ; Filaggrin Proteins ; Gene Expression ; Humans ; Lipid Metabolism/genetics ; Male ; Phenotype ; Severity of Illness Index ; Tanzania ; Black or African American
مستخلص: Background: Atopic dermatitis (AD) is a common disease, with particularly high prevalence found in Africa. It is increasingly recognized that patients with AD of different ethnic backgrounds have unique molecular signatures in the skin, potentially accounting for treatment response variations. Nevertheless, the skin profile of patients with AD from Africa is unknown, hindering development of new treatments targeted to this patient population.
Objective: To characterize the skin profile of patients with AD from Africa.
Methods: Gene expression studies, including RNA sequencing (using threshold of fold change of >2 and false discovery rate of <0.05) and real-time polymerase chain reaction, were performed on skin biopsies of Tanzanian patients with moderate-to-severe AD and controls.
Results: Tanzanian AD skin presented robust up-regulations of multiple key mediators of both T helper 2 (T H 2) (interleukin 13 [IL-13], IL-10, IL-4R, CCL13,CCL17,CCL18,CCL26) and T H 22 (IL22, S100As) pathways. Markers related to T H 17 and IL-23 (IL-17A, IL-23A, IL-12, PI3, DEFB4B) and T H 1 (interferon gamma, CXCL9,CXCL10,CXCL11) were also significantly overexpressed in AD tissues (FDR<.05), albeit to a lesser extent. IL-36 isoforms revealed substantial up-regulations in African skin. The barrier fingerprint of Tanzanian AD revealed no suppression of hallmark epidermal barrier differentiation genes, such as filaggrin, loricrin, and periplakin, with robust attenuation of lipid metabolism genes (ie, AWAT1).
Conclusion: The skin phenotype of Tanzanian patients with AD is consistent with that of African Americans, exhibiting dominant T H 2 and T H 22 skewing, minimal dysregulation of terminal differentiation, and even broader attenuation of lipid metabolism-related products. These data highlight the unique characteristic of AD in Black individuals and the need to develop unique treatments targeting patients with AD from these underrepresented populations.
(Copyright © 2021 American College of Allergy, Asthma & Immunology. Published by Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: UL1 TR001866 United States TR NCATS NIH HHS
المشرفين على المادة: 0 (Cytokines)
0 (FLG protein, human)
0 (Filaggrin Proteins)
تواريخ الأحداث: Date Created: 20210511 Date Completed: 20210917 Latest Revision: 20240825
رمز التحديث: 20240826
مُعرف محوري في PubMed: PMC11344219
DOI: 10.1016/j.anai.2021.04.023
PMID: 33975024
قاعدة البيانات: MEDLINE
الوصف
تدمد:1534-4436
DOI:10.1016/j.anai.2021.04.023