دورية أكاديمية
A novel simple and sensitive approach for determination of 1,1-dimethylhydrazine in aqueous samples by high performance liquid chromatography with ultraviolet and tandem mass spectrometric detection after derivatization with unsubstituted aromatic aldehydes.
| العنوان: | A novel simple and sensitive approach for determination of 1,1-dimethylhydrazine in aqueous samples by high performance liquid chromatography with ultraviolet and tandem mass spectrometric detection after derivatization with unsubstituted aromatic aldehydes. |
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| المؤلفون: | Timchenko YV; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, GSP-1, Moscow, 119991, Russia. Electronic address: iurii.timchenko@chemistry.msu.ru., Stavrianidi AN; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, GSP-1, Moscow, 119991, Russia; A.N. Frumkin Institute of Physical Chemistry and Electrochemistry, Russian Academy of Sciences, Leninsky Prospect, 31, GSP-1, Moscow, 119071, Russia., Smolenkov AD; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, GSP-1, Moscow, 119991, Russia., Pirogov AV; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, GSP-1, Moscow, 119991, Russia., Shpigun OA; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, GSP-1, Moscow, 119991, Russia. |
| المصدر: | Chemosphere [Chemosphere] 2021 Oct; Vol. 280, pp. 130747. Date of Electronic Publication: 2021 May 03. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Ltd Country of Publication: England NLM ID: 0320657 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-1298 (Electronic) Linking ISSN: 00456535 NLM ISO Abbreviation: Chemosphere Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Oxford : Elsevier Science Ltd Original Publication: Oxford, New York, : Pergamon Press. |
| مواضيع طبية MeSH: | Aldehydes* , Tandem Mass Spectrometry*, Chromatography, High Pressure Liquid ; Dimethylhydrazines ; Water |
| مستخلص: | In this work, simple, rapid and highly sensitive method of hazardous chemical 1,1-dimethylhydrazine (unsymmetrical dimethylhydrazine, UDMH) determination based on pre-column derivatization with unsubstituted aromatic aldehydes and reversed-phase high performance liquid chromatography-ultraviolet-tandem mass spectrometry (RP HPLC-UV-MS/MS) has been developed. Along with benzaldehyde, commercially available aromatic aldehydes, namely: 2-naphthaldehyde, 2-pyridinecarboxaldehyde, and 2-quinolinecarboxaldehyde, were used as derivatizing reagents in the analysis of hydrazines for the first time. The reactions were studied in a wide pH range by varying reaction time and other conditions. A slightly alkaline pH 9 was shown to be optimal for the derivatization of UDMH by aromatic aldehydes. The quantitative yield of derivatization products under the established conditions was confirmed by HPLC analysis with amperometric detection. For all studied reagents, wide linear ranges of concentrations (0.01-1000 μg/L) in natural water samples were observed. The limits of detection for UDMH in natural water were in the 3.7-130 ng/L range. 2-Quinolinecarboxaldehyde was selected as the most appropriate reagent for HPLC-UV-MS/MS determination of UDMH. In case of using this reagent, the accuracy was in the range of 97-102%, and precision, expressed as RSD was less than 8%. The developed approach does not require laborious stages of pre-concentration and isolation of UDMH from natural water components. (Copyright © 2021 Elsevier Ltd. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 1,1-Dimethylhydrazine (unsymmetrical dimethylhydrazine; Aqueous samples; Aromatic aldehydes; Derivatization; High performance liquid chromatography; Tandem mass spectrometric detection; UDMH) |
| المشرفين على المادة: | 0 (Aldehydes) 0 (Dimethylhydrazines) 059QF0KO0R (Water) 4WPQ90N53J (dimazine) |
| تواريخ الأحداث: | Date Created: 20210511 Date Completed: 20210623 Latest Revision: 20210623 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.chemosphere.2021.130747 |
| PMID: | 33975236 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-1298 |
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| DOI: | 10.1016/j.chemosphere.2021.130747 |