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Efficacy of dietary supplements containing isolated organic compounds for weight loss: a systematic review and meta-analysis of randomised placebo-controlled trials.

التفاصيل البيبلوغرافية
العنوان: Efficacy of dietary supplements containing isolated organic compounds for weight loss: a systematic review and meta-analysis of randomised placebo-controlled trials.
المؤلفون: Bessell E; The University of Sydney, The Boden Collaboration for Obesity, Nutrition, Exercise & Eating Disorders, Charles Perkins Centre, Faculty of Medicine and Health, Sydney, NSW, Australia. erica.bessell@sydney.edu.au., Maunder A; The University of Sydney, The Boden Collaboration for Obesity, Nutrition, Exercise & Eating Disorders, Charles Perkins Centre, Faculty of Medicine and Health, Sydney, NSW, Australia.; Western Sydney University, NICM Health Research Institute, Penrith, NSW, Australia., Lauche R; Southern Cross University, National Centre for Naturopathic Medicine, Lismore, NSW, Australia.; University of Technology Sydney, Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), School of Public Health, Faculty of Health, Sydney, NSW, Australia., Adams J; University of Technology Sydney, Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), School of Public Health, Faculty of Health, Sydney, NSW, Australia., Sainsbury A; The University of Western Australia, School of Human Sciences, Faculty of Science, Perth, WA, Australia., Fuller NR; The University of Sydney, The Boden Collaboration for Obesity, Nutrition, Exercise & Eating Disorders, Charles Perkins Centre, Faculty of Medicine and Health, Sydney, NSW, Australia.
المصدر: International journal of obesity (2005) [Int J Obes (Lond)] 2021 Aug; Vol. 45 (8), pp. 1631-1643. Date of Electronic Publication: 2021 May 11.
نوع المنشور: Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101256108 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5497 (Electronic) Linking ISSN: 03070565 NLM ISO Abbreviation: Int J Obes (Lond) Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Pub. Group, c2005-
مواضيع طبية MeSH: Dietary Supplements*, Weight Loss/*drug effects, Chitosan/pharmacology ; Fructans/pharmacology ; Humans ; Linoleic Acids, Conjugated/pharmacology ; Mannans/pharmacology ; Randomized Controlled Trials as Topic ; Treatment Outcome
مستخلص: Background/objectives: A systematic review with meta-analysis was conducted to synthesise evidence on the efficacy of dietary supplements containing isolated organic compounds for weight loss.
Subjects/methods: Four electronic databases (Medline, Embase, Web of Science, Cinahl) were searched until December 2019. Sixty-seven randomised placebo-controlled trials of dietary supplements containing isolated organic compounds for weight loss were included. Meta-analyses were conducted for chitosan, glucomannan, conjugated linoleic acid and fructans, comparing mean weight difference post-intervention between participants receiving the dietary supplement or placebo.
Results: Statistically significant weight differences compared to placebo were observed for chitosan (-1.84 kg; 95% confidence interval [CI] -2.79, -0.88; p < 0.01), glucomannan (-1.27 kg; 95%CI -2.45, -0.09; p = 0.04), and conjugated linoleic acid (-1.08 kg; 95%CI -1.61, -0.55; p < 0.01). None met our threshold for clinical significance (≥2.5 kg). There was no statistically significant effect on weight for fructans compared to placebo (p = 0.24). For dietary supplements with an inadequate number of trials for meta-analysis, a statistically and borderline clinically significant weight difference compared to placebo was found for modified cellulose, manno-oligosaccharides (in males), blood orange juice extract, and three multiple-ingredient dietary supplements. These were only reported in one trial of each. Thus, more evidence is needed before recommending them for weight loss.
Conclusions: While some dietary supplements containing isolated organic compounds warrant further investigation to determine efficacy and safety, there is currently insufficient evidence to recommend any of these dietary supplements for weight loss.
(© 2021. The Author(s), under exclusive licence to Springer Nature Limited.)
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المشرفين على المادة: 0 (Fructans)
0 (Linoleic Acids, Conjugated)
0 (Mannans)
36W3E5TAMG ((1-6)-alpha-glucomannan)
9012-76-4 (Chitosan)
تواريخ الأحداث: Date Created: 20210512 Date Completed: 20220128 Latest Revision: 20230202
رمز التحديث: 20231215
DOI: 10.1038/s41366-021-00839-w
PMID: 33976376
قاعدة البيانات: MEDLINE
الوصف
تدمد:1476-5497
DOI:10.1038/s41366-021-00839-w