دورية أكاديمية
Efficacy of dietary supplements containing isolated organic compounds for weight loss: a systematic review and meta-analysis of randomised placebo-controlled trials.
العنوان: | Efficacy of dietary supplements containing isolated organic compounds for weight loss: a systematic review and meta-analysis of randomised placebo-controlled trials. |
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المؤلفون: | Bessell E; The University of Sydney, The Boden Collaboration for Obesity, Nutrition, Exercise & Eating Disorders, Charles Perkins Centre, Faculty of Medicine and Health, Sydney, NSW, Australia. erica.bessell@sydney.edu.au., Maunder A; The University of Sydney, The Boden Collaboration for Obesity, Nutrition, Exercise & Eating Disorders, Charles Perkins Centre, Faculty of Medicine and Health, Sydney, NSW, Australia.; Western Sydney University, NICM Health Research Institute, Penrith, NSW, Australia., Lauche R; Southern Cross University, National Centre for Naturopathic Medicine, Lismore, NSW, Australia.; University of Technology Sydney, Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), School of Public Health, Faculty of Health, Sydney, NSW, Australia., Adams J; University of Technology Sydney, Australian Research Centre in Complementary and Integrative Medicine (ARCCIM), School of Public Health, Faculty of Health, Sydney, NSW, Australia., Sainsbury A; The University of Western Australia, School of Human Sciences, Faculty of Science, Perth, WA, Australia., Fuller NR; The University of Sydney, The Boden Collaboration for Obesity, Nutrition, Exercise & Eating Disorders, Charles Perkins Centre, Faculty of Medicine and Health, Sydney, NSW, Australia. |
المصدر: | International journal of obesity (2005) [Int J Obes (Lond)] 2021 Aug; Vol. 45 (8), pp. 1631-1643. Date of Electronic Publication: 2021 May 11. |
نوع المنشور: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Systematic Review |
اللغة: | English |
بيانات الدورية: | Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101256108 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5497 (Electronic) Linking ISSN: 03070565 NLM ISO Abbreviation: Int J Obes (Lond) Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Nature Pub. Group, c2005- |
مواضيع طبية MeSH: | Dietary Supplements*, Weight Loss/*drug effects, Chitosan/pharmacology ; Fructans/pharmacology ; Humans ; Linoleic Acids, Conjugated/pharmacology ; Mannans/pharmacology ; Randomized Controlled Trials as Topic ; Treatment Outcome |
مستخلص: | Background/objectives: A systematic review with meta-analysis was conducted to synthesise evidence on the efficacy of dietary supplements containing isolated organic compounds for weight loss. Subjects/methods: Four electronic databases (Medline, Embase, Web of Science, Cinahl) were searched until December 2019. Sixty-seven randomised placebo-controlled trials of dietary supplements containing isolated organic compounds for weight loss were included. Meta-analyses were conducted for chitosan, glucomannan, conjugated linoleic acid and fructans, comparing mean weight difference post-intervention between participants receiving the dietary supplement or placebo. Results: Statistically significant weight differences compared to placebo were observed for chitosan (-1.84 kg; 95% confidence interval [CI] -2.79, -0.88; p < 0.01), glucomannan (-1.27 kg; 95%CI -2.45, -0.09; p = 0.04), and conjugated linoleic acid (-1.08 kg; 95%CI -1.61, -0.55; p < 0.01). None met our threshold for clinical significance (≥2.5 kg). There was no statistically significant effect on weight for fructans compared to placebo (p = 0.24). For dietary supplements with an inadequate number of trials for meta-analysis, a statistically and borderline clinically significant weight difference compared to placebo was found for modified cellulose, manno-oligosaccharides (in males), blood orange juice extract, and three multiple-ingredient dietary supplements. These were only reported in one trial of each. Thus, more evidence is needed before recommending them for weight loss. Conclusions: While some dietary supplements containing isolated organic compounds warrant further investigation to determine efficacy and safety, there is currently insufficient evidence to recommend any of these dietary supplements for weight loss. (© 2021. The Author(s), under exclusive licence to Springer Nature Limited.) |
References: | Maunder A, Bessell E, Lauche R, Adams J, Sainsbury A, Fuller NR. Effectiveness of herbal medicines for weight loss: a systematic review and meta-analysis of randomized controlled trials. Diabetes Obes Metab. 2020;22:891–903. https://doi.org/10.1111/dom.13973 . (PMID: 10.1111/dom.1397331984610) FDA 101: Dietary supplements. US Food and Drug Administration. Published July 15, 2015. Updated June 11, 2017. Accessed January 7, 2018. www.fda.gov/consumers/consumer-updates/fda-101-dietary-supplements . Tamayo C, Hoffman FA. Canada’s natural health products: a regulatory overview. Pharmaceut Reg Affairs. 2016;5:174. Esteghamati A, Mazaheri T, Vahidi Rad M, Noshad S. Complementary and alternative medicine for the treatment of obesity: a critical review. Int J Endocrinol Metab. 2015;13:e19678. (PMID: 25892995438622810.5812/ijem.19678) Barrea L, Altieri B, Polese B, De Conno B, Muscogiuri G, Colao A, et al. Nutritionist and obesity: brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements. Int J Obes Suppl. 2019;9:32–49. (PMID: 31391923668312710.1038/s41367-019-0007-3) Zalewski BM, Chmielewska A, Szajewska H. The effect of glucomannan on body weight in overweight or obese children and adults: a systematic review of randomized controlled trials. Nutrition. 2015;31:437–42.e2. (PMID: 2570133110.1016/j.nut.2014.09.004) Zalewski BM, Chmielewska A, Szajewska H, Keithley JK, Li P, Goldsby TU, et al. Correction of data errors and reanalysis of “The effect of glucomannan on body weight in overweight or obese children and adults: a systematic review of randomized controlled trials”. Nutrition. 2015;31:1056–7. (PMID: 26059384486809010.1016/j.nut.2015.02.008) Huang H, Liao D, Zou Y, Chi H. The effects of chitosan supplementation on body weight and body composition: a systematic review and meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2020;60:1815–25. (PMID: 3099005910.1080/10408398.2019.1602822) Namazi N, Irandoost P, Larijani B, Azadbakht L. The effects of supplementation with conjugated linoleic acid on anthropometric indices and body composition in overweight and obese subjects: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2019;59:2720–33. (PMID: 2967212410.1080/10408398.2018.1466107) Pittler MH, Ernst E. Dietary supplements for body-weight reduction: a systematic review. Am J Clin Nutr. 2004;79:529–36. (PMID: 1505159310.1093/ajcn/79.4.529) Moher D, Liberati A, Tetzlaff J, Altman DG. PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. BMJ. 2009;339:b2535. (PMID: 19622551271465710.1136/bmj.b2535) Higgins JPT, Green S (eds) Cochrane handbook for systematic reviews of interventions. Version 5.1.0. The Cochrane Collaboration; 2011. www.handbook.cochrane.org . WHO Expert Consultation. Appropriate body-mass index for Asian populations and its implications for policy and intervention strategies. Lancet. 2004;363:157–63. Caterson ID, Finer N, Coutinho W, Van Gaal LF, Maggioni AP, Torp-Pedersen C, et al. Maintained intentional weight loss reduces cardiovascular outcomes: results from the Sibutramine Cardiovascular OUTcomes (SCOUT) trial. Diabetes Obes Metab. 2012;14:523–30. (PMID: 2219233810.1111/j.1463-1326.2011.01554.x) Wing RR, Lang W, Wadden TA, Safford M, Knowler WC, Bertoni AG, et al. Benefits of modest weight loss in improving cardiovascular risk factors in overweight and obese individuals with type 2 diabetes. Diabetes Care. 2011;34:1481–6. (PMID: 21593294312018210.2337/dc10-2415) Borenstein M, Hedges LV, Higgins JPT, Rothstein HR. Introduction to meta-analysis. Chichester, UK: John Wiley & Sons; 2009:107–19. Higgins J, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003;327:557–60. (PMID: 1295812019285910.1136/bmj.327.7414.557) Kaats GR, Michalek JE, Preuss HG. Evaluating efficacy of a chitosan product using a double-blinded, placebo-controlled protocol. J Am Coll Nutr. 2006;25:389–94. (PMID: 1703100710.1080/07315724.2006.10719550) Pittler MH, Abbot NC, Harkness EF, Ernst E. Randomized, double-blind trial of chitosan for body weight reduction. Eur J Clin Nutr. 1999;53:379–81. (PMID: 1036949310.1038/sj.ejcn.1600733) Schiller RN, Barrager E, Schauss AG, Nichols EJ. A randomized, double-blind, placebo-controlled study examining the effects of a rapidly soluble chitosan dietary supplement on weight loss and body composition in overweight and mildly obese individuals. J Am Nutr Assoc. 2001;4:42–9. Ni Mhurchu C, Poppitt SD, McGill AT, Leahy FE, Bennett DA, Lin RB, et al. The effect of the dietary supplement, Chitosan, on body weight: a randomised controlled trial in 250 overweight and obese adults. Int J Obes Relat Metab Disord. 2004;28:1149–56. (PMID: 1531121810.1038/sj.ijo.0802693) Cornelli U, Belcaro G, Recchia M, D’Orazio N. Long-term treatment of overweight and obesity with polyglucosamine (PG L112): randomized study compared with placebo in subjects after caloric restriction. Curr Dev Nutr. 2017;1:e000919. (PMID: 29955677599877210.3945/cdn.117.000919) Pokhis K, Bitterlich N, Cornelli U, Cassano G. Efficacy of polyglucosamine for weight loss-confirmed in a randomized double-blind, placebo-controlled clinical investigation. BMC Obes. 2015;2:25. (PMID: 26217540451102610.1186/s40608-015-0053-5) Willers J, Plötz SC, Hahn A. The combination of a high-protein formula diet and polyglucosamine decreases body weight and parameters of glucose and lipid metabolism in overweight and obese men and women. Eur J Food Res Rev. 2012;2:29–45. Williams AR. A double-blind, placebo-controlled evaluation of the effects of RW94 on the body weight of both overweight and obese healthy volunteers. Curr Med Res Opin. 1998;14:243–9. (PMID: 989119710.1185/03007999809113365) Jung EY, Jun SC, Chang UJ, Suh HJ. L-ascorbic acid addition to chitosan reduces body weight in overweight women. Int J Vitam Nutr Res. 2014;84:5–11. (PMID: 2583523010.1024/0300-9831/a000187) Woodgate DE, Conquer JA. Effects of a stimulant-free dietary supplement on body weight and fat loss in obese adults: a six-week exploratory study. Curr Ther Res Clin Exp. 2003;64:248–62. (PMID: 24944372405299510.1016/S0011-393X(03)00058-4) Keithley JK, Swanson B, Mikolaitis SL, DeMeo M, Zeller JM, Fogg L, et al. Safety and efficacy of glucomannan for weight loss in overweight and moderately obese adults. J Obes. 2013;2013:610908. (PMID: 24490058389293310.1155/2013/610908) Walsh DE, Yaghoubian V, Behforooz A. Effect of glucomannan on obese patients: a clinical study. Int J Obes. 1984;8:289–93. (PMID: 6096282) Birketvedt GS, Shimshi M, Erling T, Florholmen J. Experiences with three different fiber supplements in weight reduction. Med Sci Monit. 2005;11:PI5–8. (PMID: 15614200) Lyon M, Wood S, Pelletier X, Donazzolo Y, Gahler R, Bellisle F. Effects of a 3-month supplementation with a novel soluble highly viscous polysaccharide on anthropometry and blood lipids in nondieting overweight or obese adults. J Hum Nutr Diet. 2011;24:351–9. (PMID: 2141404510.1111/j.1365-277X.2011.01157.x) Pal S, Ho S, Gahler RJ, Wood S. Effect on body weight and composition in overweight/obese Australian adults over 12 months consumption of two different types of fibre supplementation in a randomized trial. Nutr Metab (Lond). 2016;13:82. (PMID: 27891167511474210.1186/s12986-016-0141-7) Salas-Salvado J, Farres X, Luque X, Narejos S, Borrell M, Basora J, et al. Effect of two doses of a mixture of soluble fibres on body weight and metabolic variables in overweight or obese patients: a randomised trial. Br J Nutr. 2008;99:1380–7. (PMID: 1803159210.1017/S0007114507868528) von Hippel PT. The heterogeneity statistic I(2) can be biased in small meta-analyses. BMC Med Res Methodol. 2015;15:35. (PMID: 10.1186/s12874-015-0024-z) Genta S, Cabrera W, Habib N, Pons J, Carillo IM, Grau A, et al. Yacon syrup: beneficial effects on obesity and insulin resistance in humans. Clin Nutr. 2009;28:182–7. (PMID: 1925481610.1016/j.clnu.2009.01.013) Parnell JA, Reimer RA. Weight loss during oligofructose supplementation is associated with decreased ghrelin and increased peptide YY in overweight and obese adults. Am J Clin Nutr. 2009;89:1751–9. (PMID: 1938674110.3945/ajcn.2009.27465) Hess AL, Benitez-Paez A, Blaedel T, Larsen LH, Iglesias JR, Madera C, et al. The effect of inulin and resistant maltodextrin on weight loss during energy restriction: a randomised, placebo-controlled, double-blinded intervention. Eur J Nutr. 2019; https://doi.org/10.1007/s00394-019-02099-x . Uebelhack R, Bongartz U, Seibt S, Bothe G, Chong PW, De Costa P, et al. Double-blind, randomized, three-armed, placebo-controlled, clinical investigation to evaluate the benefit and tolerability of two dosages of IQP-AE-103 in reducing body weight in overweight and moderately obese subjects. J Obes. 2019;2019:3412952. (PMID: 308636326377993) Aoe S, Ichinose Y, Kohyama N, Komae K, Takahashi A, Abe D, et al. Effects of high beta-glucan barley on visceral fat obesity in Japanese individuals: a randomized, double-blind study. Nutrition. 2017;42:1–6. (PMID: 2887047210.1016/j.nut.2017.05.002) Chang HC, Huang CN, Yeh DM, Wang SJ, Peng CH, Wang CJ. Oat prevents obesity and abdominal fat distribution, and improves liver function in humans. Plant Foods Hum Nutr. 2013;68:18–23. (PMID: 2337178510.1007/s11130-013-0336-2) Santas J, Lazaro E, Cune J. Effect of a polysaccharide-rich hydrolysate from Saccharomyces cerevisiae (LipiGo(R)) in body weight loss: randomised, double-blind, placebo-controlled clinical trial in overweight and obese adults. J Sci Food Agric. 2017;97:4250–7. (PMID: 2825165410.1002/jsfa.8301) Grube B, Chong PW, Alt F, Uebelhack R. Weight maintenance with Litramine (IQP-G-002AS): a 24-week double-blind, randomized, placebo-controlled study. J Obes. 2015;2015:953138. (PMID: 26435849457601810.1155/2015/953138) Grube B, Chong PW, Lau KZ, Orzechowski HD. A natural fiber complex reduces body weight in the overweight and obese: a double-blind, randomized, placebo-controlled study. Obesity (Silver Spring). 2013;21:58–64. (PMID: 10.1002/oby.20244) Fragala MS, Kraemer WJ, Volek JS, Maresh CM, Puglisi MJ, Vingren JL, et al. Influences of a dietary supplement in combination with an exercise and diet regimen on adipocytokines and adiposity in women who are overweight. Eur J Appl Physiol. 2009;105:665–72. (PMID: 1904827710.1007/s00421-008-0944-y) Guerin-Deremaux L, Li S, Pochat M, Wils D, Mubasher M, Reifer C, et al. Effects of NUTRIOSE(R) dietary fiber supplementation on body weight, body composition, energy intake, and hunger in overweight men. Int J Food Sci Nutr. 2011;62:628–35. (PMID: 2159198510.3109/09637486.2011.569492) Georg Jensen M, Kristensen M, Astrup A. Effect of alginate supplementation on weight loss in obese subjects completing a 12-wk energy-restricted diet: a randomized controlled trial. Am J Clin Nutr. 2012;96:5–13. (PMID: 2264870910.3945/ajcn.111.025312) Lambert JE, Parnell JA, Tunnicliffe JM, Han J, Sturzenegger T, Reimer RA. Consuming yellow pea fiber reduces voluntary energy intake and body fat in overweight/obese adults in a 12-week randomized controlled trial. Clin Nutr. 2017;36:126–33. (PMID: 2681113010.1016/j.clnu.2015.12.016) St-Onge MP, Salinardi T, Herron-Rubin K, Black RM. A weight-loss diet including coffee-derived mannooligosaccharides enhances adipose tissue loss in overweight men but not women. Obesity (Silver Spring). 2012;20:343–8. (PMID: 10.1038/oby.2011.289) Hu X, Gao J, Zhang Q, Fu Y, Li K, Zhu S, et al. Soy fiber improves weight loss and lipid profile in overweight and obese adults: a randomized controlled trial. Mol Nutr Food Res. 2013;57:2147–54. (PMID: 2388177410.1002/mnfr.201300159) Lopez-Plaza B, Bermejo LM, Koester Weber T, Parra P, Serra F, Hernandez M, et al. Effects of milk supplementation with conjugated linoleic acid on weight control and body composition in healthy overweight people. Nutr Hosp. 2013;28:2090–8. (PMID: 24506387) Watras AC, Buchholz AC, Close RN, Zhang Z, Schoeller DA. The role of conjugated linoleic acid in reducing body fat and preventing holiday weight gain. Int J Obes (Lond). 2007;31:481–7. (PMID: 10.1038/sj.ijo.0803437) Madry E, Chudzicka-Strugala I, Grabanska-Martynska K, Malikowska K, Grebowiec P, Lisowska A, et al. Twelve weeks CLA supplementation decreases the hip circumference in overweight and obese women. A double-blind, randomized, placebo-controlled trial. Acta Sci Pol Technol Aliment. 2016;15:107–13. (PMID: 2807104410.17306/J.AFS.2016.1.11) Gaullier JM, Halse J, Hoye K, Kristiansen K, Fagertun H, Vik H, et al. Conjugated linoleic acid supplementation for 1 y reduces body fat mass in healthy overweight humans. Am J Clin Nutr. 2004;79:1118–25. (PMID: 1515924410.1093/ajcn/79.6.1118) Gaullier JM, Halse J, Hoivik HO, Hoye K, Syvertsen C, Nurminiemi M, et al. Six months supplementation with conjugated linoleic acid induces regional-specific fat mass decreases in overweight and obese. Br J Nutr. 2007;97:550–60. (PMID: 1731371810.1017/S0007114507381324) Chen SC, Lin YH, Huang HP, Hsu WL, Houng JY, Huang CK. Effect of conjugated linoleic acid supplementation on weight loss and body fat composition in a Chinese population. Nutrition. 2012;28:559–65. (PMID: 2226157810.1016/j.nut.2011.09.008) Berven G, Bye A, Hals O, Blankson H, Fagertun H, Thom E, et al. Safety of conjugated linoleic acid (CLA) in overweight or obese human volunteers. Eur J Lipid Sci Technol. 2000;102:455–62. (PMID: 10.1002/1438-9312(200008)102:7<455::AID-EJLT455>3.0.CO;2-V) Blankson H, Stakkestad JA, Fagertun H, Thom E, Wadstein J, Gudmundsen O. Conjugated linoleic acid reduces body fat mass in overweight and obese humans. J Nutr. 2000;130:2943–8. (PMID: 1111085110.1093/jn/130.12.2943) Steck SE, Chalecki AM, Miller P, Conway J, Austin GL, Hardin JW, et al. Conjugated linoleic acid supplementation for twelve weeks increases lean body mass in obese humans. J Nutr. 2007;137:1188–93. (PMID: 1744958010.1093/jn/137.5.1188) Rao AV, Andrews K, Logan A. A double-blind, randomized-controlled trial of a nutritional supplement (abs+) containing conjugated linoleic acid (CLA) and epigallocatechin-gallate (EGCG) in human weight loss. J Herbs Spices Med Plants. 2007;12:67–76. (PMID: 10.1300/J044v12n03_05) Mangine GT, Gonzalez AM, Wells AJ, McCormack WP, Fragala MS, Stout JR, et al. The effect of a dietary supplement (N-oleyl-phosphatidyl-ethanolamine and epigallocatechin gallate) on dietary compliance and body fat loss in adults who are overweight: a double-blind, randomized control trial. Lipids Health Dis. 2012;11:127. (PMID: 23033919349082810.1186/1476-511X-11-127) Rondanelli M, Opizzi A, Solerte SB, Trotti R, Klersy C, Cazzola R. Administration of a dietary supplement (N-oleyl-phosphatidylethanolamine and epigallocatechin-3-gallate formula) enhances compliance with diet in healthy overweight subjects: a randomized controlled trial. Br J Nutr. 2009;101:457–64. (PMID: 1859058710.1017/S0007114508024008) Laleh P, Yaser K, Abolfazl B, Shahriar A, Mohammad AJ, Nazila F, et al. Oleoylethanolamide increases the expression of PPAR-Alpha and reduces appetite and body weight in obese people: a clinical trial. Appetite. 2018;128:44–9. (PMID: 2978783110.1016/j.appet.2018.05.129) Tominaga Y, Mae T, Kitano M, Sakamoto Y, Ikematsu H, Nakagawa K. Licorice flavonoid oil effects body weight loss by reduction of body fat mass in overweight subjects. J Health Sci. 2006;52:672–83. (PMID: 10.1248/jhs.52.672) Tominaga Y, Nakagawa K, Mae T, Kitano M, Yokota S, Arai T, et al. Licorice flavonoid oil reduces total body fat and visceral fat in overweight subjects: a randomized, double-blind, placebo-controlled study. Obes Res Clin Pract. 2009;3:I–IV. (PMID: 2434558710.1016/j.orcp.2009.04.005) Mahdavi R, Alizadeh M, Namazi N, Farajnia S. Changes of body composition and circulating adipokines in response to Nigella sativa oil with a calorie restricted diet in obese women. J Herb Med. 2016;6:67–72. (PMID: 10.1016/j.hermed.2016.03.003) Snitker S, Fujishima Y, Shen H, Ott S, Pi-Sunyer X, Furuhata Y, et al. Effects of novel capsinoid treatment on fatness and energy metabolism in humans: possible pharmacogenetic implications. Am J Clin Nutr. 2009;89:45–50. (PMID: 1905657610.3945/ajcn.2008.26561) Munro IA, Garg ML. Dietary supplementation with n-3 PUFA does not promote weight loss when combined with a very-low-energy diet. Br J Nutr. 2012;108:1466–74. (PMID: 2221484210.1017/S0007114511006817) Krotkiewski M. Value of VLCD supplementation with medium chain triglycerides. Int J Obes Relat Metab Disord. 2001;25:1393–400. (PMID: 1157160510.1038/sj.ijo.0801682) Kondo T, Kishi M, Fushimi T, Ugajin S, Kaga T. Vinegar intake reduces body weight, body fat mass, and serum triglyceride levels in obese Japanese subjects. Biosci Biotechnol Biochem. 2009;73:1837–43. (PMID: 1966168710.1271/bbb.90231) Shin HC, Kim SH, Park Y, Lee BH, Hwang HJ. Effects of 12-week oral supplementation of Ecklonia cava polyphenols on anthropometric and blood lipid parameters in overweight Korean individuals: a double-blind randomized clinical trial. Phytother Res. 2012;26:363–8. (PMID: 2171751610.1002/ptr.3559) Munguia L, Gutierrez-Salmean G, Hernandez M, Ortiz A, Sanchez ME, Najera N, et al. Beneficial effects of a flavanol-enriched cacao beverage on anthropometric and cardiometabolic risk profile in overweight subjects. Rev Mex Cardiol. 2015;26:78–86. Cardile V, Graziano AC, Venditti A. Clinical evaluation of Moro (Citrus sinensis (L.) Osbeck) orange juice supplementation for the weight management. Nat Prod Res. 2015;29:2256–60. (PMID: 2558836910.1080/14786419.2014.1000897) Dallas C, Gerbi A, Elbez Y, Caillard P, Zamaria N, Cloarec M. Clinical study to assess the efficacy and safety of a citrus polyphenolic extract of red orange, grapefruit, and orange (Sinetrol-XPur) on weight management and metabolic parameters in healthy overweight individuals. Phytother Res. 2014;28:212–8. (PMID: 2355402910.1002/ptr.4981) Choi HC, Kim SJ, Son KY, Oh BJ, Cho BL. Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial. Nutrition. 2013;29:1110–4. (PMID: 2373531710.1016/j.nut.2013.02.015) Kwak JH, Ahn CW, Park SH, Jung SU, Min BJ, Kim OY, et al. Weight reduction effects of a black soy peptide supplement in overweight and obese subjects: double blind, randomized, controlled study. Food Funct. 2012;3:1019–24. (PMID: 2273962410.1039/c2fo10244g) Arent SM, Walker AJ, Pellegrino JK, Sanders DJ, McFadden BA, Ziegenfuss TN, et al. The combined effects of exercise, diet, and a multi-ingredient dietary supplement on body composition and adipokine changes in overweight adults. J Am Coll Nutr. 2018;37:111–20. (PMID: 2911188910.1080/07315724.2017.1368039) Lopez HL, Ziegenfuss TN, Hofheins JE, Habowski SM, Arent SM, Weir JP, et al. Eight weeks of supplementation with a multi-ingredient weight loss product enhances body composition, reduces hip and waist girth, and increases energy levels in overweight men and women. J Int Soc Sports Nutr. 2013;10:22. (PMID: 23601452363982610.1186/1550-2783-10-22) Hackman RM, Havel PJ, Schwartz HJ, Rutledge JC, Watnik MR, Noceti EM, et al. Multinutrient supplement containing ephedra and caffeine causes weight loss and improves metabolic risk factors in obese women: a randomized controlled trial. Int J Obes (Lond). 2006;30:1545–56. (PMID: 10.1038/sj.ijo.0803283) Gonzalez MJ, Miranda-Massari JR, Ricart CM. Effect of a dietary supplement combination on weight management, adipose tissue, cholesterol and triglycerides in obese subjects. P R Health Sci J. 2004;23:121–4. (PMID: 15377061) Zemel MB, Bruckbauer A. Effects of a leucine and pyridoxine-containing nutraceutical on body weight and composition in obese subjects. Diabetes Metab Syndr Obes. 2013;6:309–15. (PMID: 24003309375570210.2147/DMSO.S49623) Ormsbee MJ, Rawal SR, Baur DA, Kinsey AW, Elam ML, Spicer MT, et al. The effects of a multi-ingredient dietary supplement on body composition, adipokines, blood lipids, and metabolic health in overweight and obese men and women: a randomized controlled trial. J Int Soc Sports Nutr. 2014;11:37. (PMID: 25093015412073010.1186/1550-2783-11-37) Kalman D, Colker CM, Stark R, Minsch A, Wilets I, Antonio J. Effect of pyruvate supplementation on body composition and mood. Curr Ther Res. 1998;59:793–802. (PMID: 10.1016/S0011-393X(98)85105-9) Cha YS, Kim SR, Yang JA, Back HI, Kim MG, Jung SJ, et al. Kochujang, fermented soybean-based red pepper paste, decreases visceral fat and improves blood lipid profiles in overweight adults. Nutr Metab (Lond). 2013;10:24. (PMID: 23442518359963610.1186/1743-7075-10-24) Romain C, Alcaraz PE, Chung LH, Cases J. Regular consumption of HolisFiit, a polyphenol-rich extract-based food supplement, improves mind and body well-being of overweight and slightly obese volunteers: a randomized, double-blind, parallel trial. Int J Food Sci Nutr. 2017;68:840–8. (PMID: 2827690110.1080/09637486.2017.1292221) Gonzalez AM, Sell KM, Ghigiarelli JJ, Spitz RW, Accetta MR, Mangine GT. Effect of multi-ingredient supplement containing satiereal, naringin, and vitamin D on body composition, mood, and satiety in overweight adults. J Diet Suppl. 2018;15:965–76. (PMID: 2933662810.1080/19390211.2017.1407385) Liber A, Szajewska H. Effects of inulin-type fructans on appetite, energy intake, and body weight in children and adults: systematic review of randomized controlled trials. Ann Nutr Metab. 2013;63:42–54. (PMID: 2388718910.1159/000350312) |
المشرفين على المادة: | 0 (Fructans) 0 (Linoleic Acids, Conjugated) 0 (Mannans) 36W3E5TAMG ((1-6)-alpha-glucomannan) 9012-76-4 (Chitosan) |
تواريخ الأحداث: | Date Created: 20210512 Date Completed: 20220128 Latest Revision: 20230202 |
رمز التحديث: | 20231215 |
DOI: | 10.1038/s41366-021-00839-w |
PMID: | 33976376 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1476-5497 |
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DOI: | 10.1038/s41366-021-00839-w |