دورية أكاديمية
أعرض في EDS

Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease.

التفاصيل البيبلوغرافية
العنوان: Cardiovascular benefits of a home-based exercise program in patients with sickle cell disease.
المؤلفون: de Araujo Junior JA; Department of Internal Medicine, Sao Paulo State University Julio de Mesquita Filho-Unesp, Botucatu, Sao Paulo, Brazil., Antonelli Rossi DA; Department of Internal Medicine, Sao Paulo State University Julio de Mesquita Filho-Unesp, Botucatu, Sao Paulo, Brazil., Carneiro Valadão TF; Department of Internal Medicine, Sao Paulo State University Julio de Mesquita Filho-Unesp, Botucatu, Sao Paulo, Brazil., Milan-Mattos JC; Department of Physiotherapy, Federal University of Sao Carlos-UFSCar, São Carlos, Brazil., Catai AM; Department of Physiotherapy, Federal University of Sao Carlos-UFSCar, São Carlos, Brazil., Sato TO; Department of Physiotherapy, Federal University of Sao Carlos-UFSCar, São Carlos, Brazil., Hueb JC; Department of Internal Medicine, Sao Paulo State University Julio de Mesquita Filho-Unesp, Botucatu, Sao Paulo, Brazil., Zanati Bazan SG; Department of Internal Medicine, Sao Paulo State University Julio de Mesquita Filho-Unesp, Botucatu, Sao Paulo, Brazil., Hokama POM; Department of Internal Medicine, Sao Paulo State University Julio de Mesquita Filho-Unesp, Botucatu, Sao Paulo, Brazil., Hokama NK; Department of Internal Medicine, Sao Paulo State University Julio de Mesquita Filho-Unesp, Botucatu, Sao Paulo, Brazil., Roscani MG; Department of Internal Medicine, Sao Paulo State University Julio de Mesquita Filho-Unesp, Botucatu, Sao Paulo, Brazil.; Department of Medicine, Federal University of Sao Carlos-UFSCar, São Carlos, Brazil.
المصدر: PloS one [PLoS One] 2021 May 12; Vol. 16 (5), pp. e0250128. Date of Electronic Publication: 2021 May 12 (Print Publication: 2021).
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Anemia, Sickle Cell/*therapy, Adult ; Anemia, Sickle Cell/pathology ; Echocardiography ; Exercise/physiology ; Exercise Therapy/methods ; Female ; Humans ; Male ; Young Adult
مستخلص: Background: Physical inactivity is an important risk factor for cardiovascular disease. The benefits of exercise in patients with chronic diseases, including cardiovascular diseases, are well established. For patients with sickle cell disease, medical recommendation was to avoid physical exercise for fear of triggering painful crises or increasing the impairment of the cardiopulmonary function. Only recently, studies have shown safety in exercise programs for this population. Despite that, there is no report that assess the effects of physical exercise on cardiac parameters in patients with sickle cell disease.
Objective: This study aimed to evaluate the impact of regular physical exercise (a home-based program) on cardiovascular function in patients with sickle cell disease.
Design: A quasi-randomized prospective controlled trial.
Setting: During the years 2015 and 2016, we started recruiting among adult patients treated at a Brazilian Center for Patients with Sickle Cell Disease to participate in a study involving a home exercise program. The experimental (exercise) and control groups were submitted to clinical evaluation and cardiovascular tests before and after the intervention. Analysis of variance was applied to compare groups, considering time and group factors.
Participants: Twenty-seven adult outpatients with a sickle cell disease diagnosis.
Interventions: Exercise group (N = 14): a regular home-based aerobic exercise program, three to five times per week not exceeding give times per week, for eight weeks; no prescription for the control group (N = 13).
Main Outcome Measures: Echocardiographic and treadmill test parameters.
Results: The exercise group showed significant improvement in cardiovascular tests, demonstrated by increased distance traveled on a treadmill (p<0.01), increased ejection fraction (p < 0.01) and improvement of diastolic function assessed by mitral tissue Doppler E' wave on echocardiography (p = 0.04). None of the patients presented a sickle cell crisis or worsening of symptoms during the exercise program.
Conclusion: The selected home-based exercise program is safe, feasible, and promotes a favorable impact on functional capacity and cardiovascular function in sickle cell disease patients.
Competing Interests: The authors have declared that no competing interests exist.
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تواريخ الأحداث: Date Created: 20210512 Date Completed: 20211006 Latest Revision: 20231102
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8115779
DOI: 10.1371/journal.pone.0250128
PMID: 33979369
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0250128