دورية أكاديمية
Inclusion complex of clausenidin with hydroxypropyl-β-cyclodextrin: Improved physicochemical properties and anti-colon cancer activity.
العنوان: | Inclusion complex of clausenidin with hydroxypropyl-β-cyclodextrin: Improved physicochemical properties and anti-colon cancer activity. |
---|---|
المؤلفون: | Al-Abboodi AS; Basic Science Branch, Faculty of Dentistry, University of Al-Qadisiyah, Al-Diwaniyah, Iraq., Al-Sheikh WM; Basic Science Branch, Faculty of Dentistry, University of Al-Qadisiyah, Al-Diwaniyah, Iraq., Eid EEM; Depratemnt of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Saudi Arabia., Azam F; Depratemnt of Pharmaceutical Chemistry and Pharmacognosy, Unaizah College of Pharmacy, Qassim University, Saudi Arabia., Al-Qubaisi MS; Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. |
المصدر: | Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society [Saudi Pharm J] 2021 Mar; Vol. 29 (3), pp. 223-235. Date of Electronic Publication: 2021 Feb 03. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Saudi Pharmaceutical Society Country of Publication: Saudi Arabia NLM ID: 9705695 Publication Model: Print-Electronic Cited Medium: Print ISSN: 1319-0164 (Print) Linking ISSN: 13190164 NLM ISO Abbreviation: Saudi Pharm J Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: Riyadh : Saudi Pharmaceutical Society Original Publication: Riyadh, Kingdom of Saudi Arabia : The Society, |
مستخلص: | The long-term objective of the present study was to prepare, physicochemically characterize and determine the anticancer of clausenidin/hydroxypropyl-β-cyclodextrin (Clu/HPβCD) inclusion complex. We used differential scanning calorimetry, X-ray diffractometer, fourier transform infrared spectroscopy, ultraviolet-visible spectrophotometer and 13 C and 1 H nuclear magnetic resonance followed by in vitro anticancer assays. The orientation and intermolecular interactions of Clausenidin within cyclodextrin cavity were also ascertained by molecular docking simulation accomplished by AutoDock Vina. The guest molecule was welcomed by the hydrophobic cavity of the host molecule and sustained by hydrogen bond between host/guest molecules. The constant drug release with time, and increased solubility were found after successful complexation with HPβCD as confirmed by physicochemical characterizations. Clausenidin had greater cytotoxic effect on colon cancer HT29 cells when incorporated into HPβCD cavity than dissolved in DMSO. Also, from a comparison of cell viability between normal and cancer cells, a reduced side effect was observed. The Clu/HPβCD inclusion complex triggered reactive oxygen species-mediated cytotoxicity in HT29 cells. The inclusion complex-treated HT29 cells showed cell cycle arrest and death by apoptosis associated with caspases activation. The presence of HPβCD seems to aid the anticancer activity of clausenidin. (© 2021 The Author(s).) |
References: | Nat Prod Res. 2013;27(23):2216-8. (PMID: 23767409) Drug Des Devel Ther. 2017 Jun 07;11:1681-1692. (PMID: 28652706) Sci Rep. 2019 Feb 13;9(1):1882. (PMID: 30760785) Carbohydr Polym. 2020 Mar 1;231:115769. (PMID: 31888829) Molecules. 2017 Oct 31;22(11):. (PMID: 29088059) Curr Med Chem. 2018;25(10):1094-1159. (PMID: 28799496) Int J Nanomedicine. 2013;8:4115-29. (PMID: 24204141) J Ethnopharmacol. 2016 Dec 24;194:549-558. (PMID: 27729282) Phys Chem Chem Phys. 2016 Jun 1;18(22):15205-17. (PMID: 27206059) Planta Med. 2003 Feb;69(2):155-7. (PMID: 12624822) Int J Nanomedicine. 2013;8:2497-508. (PMID: 23885175) Molecules. 2018 May 11;23(5):. (PMID: 29751694) Curr Drug Discov Technol. 2009 Dec;6(4):299-305. (PMID: 20025598) Drug Des Devel Ther. 2017 Nov 23;11:3309-3319. (PMID: 29200826) Phytother Res. 2005 Aug;19(8):728-31. (PMID: 16177980) Int J Mol Sci. 2016 Oct 18;17(10):. (PMID: 27763535) J Comput Chem. 2010 Jan 30;31(2):455-61. (PMID: 19499576) Asian Pac J Cancer Prev. 2018 Apr 25;19(4):917-922. (PMID: 29693341) Biomed Pharmacother. 2019 Oct;118:109340. (PMID: 31545284) Bioorg Med Chem. 2009 Aug 15;17(16):6137-43. (PMID: 19635670) Eur J Pharm Sci. 2019 May 15;133:167-182. (PMID: 30902654) Molecules. 2019 Jul 13;24(14):. (PMID: 31337024) |
فهرسة مساهمة: | Keywords: Cell cycle; Clausenidin; Drug release; Hydroxypropyl-β-cyclodextrin; Physicochemical characterization; Reactive oxygen species |
تواريخ الأحداث: | Date Created: 20210513 Latest Revision: 20220218 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC8085604 |
DOI: | 10.1016/j.jsps.2021.01.006 |
PMID: | 33981171 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1319-0164 |
---|---|
DOI: | 10.1016/j.jsps.2021.01.006 |