دورية أكاديمية
Development of Zoledronic Acid Containing Biomaterials for Enhanced Guided Bone Regeneration.
| العنوان: | Development of Zoledronic Acid Containing Biomaterials for Enhanced Guided Bone Regeneration. |
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| المؤلفون: | Küçüktürkmen B; Faculty of Pharmacy Department of Pharmaceutical Technology, Ankara University, Ankara, Turkey., Öz UC; Faculty of Pharmacy Department of Pharmaceutical Technology, Ankara University, Ankara, Turkey. Electronic address: umutcanoz@ankara.edu.tr., Toptaş M; Faculty of Dentistry Department of Periodontology, Bezmialem University, İstanbul, Turkey., Devrim B; Faculty of Pharmacy Department of Pharmaceutical Technology, Ankara University, Ankara, Turkey., Saka OM; Faculty of Pharmacy Department of Pharmaceutical Technology, Ankara University, Ankara, Turkey., Bilgili H; Faculty of Veterinary Medicine Department of Surgery, Ankara University, Ankara, Turkey., Deveci MS; Health Sciences University Gulhane Medical Faculty Pathology Department, Ankara, Turkey., Ünsal E; Faculty of Dentistry Department of Periodontology, Ankara University, Ankara, Turkey., Bozkır A; Faculty of Pharmacy Department of Pharmaceutical Technology, Ankara University, Ankara, Turkey. |
| المصدر: | Journal of pharmaceutical sciences [J Pharm Sci] 2021 Sep; Vol. 110 (9), pp. 3200-3207. Date of Electronic Publication: 2021 May 11. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 2985195R Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1520-6017 (Electronic) Linking ISSN: 00223549 NLM ISO Abbreviation: J Pharm Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2016- : New York, NY : Elsevier Original Publication: Easton, Pa., American Pharmaceutical Assn. |
| مواضيع طبية MeSH: | Biocompatible Materials* , Bone Regeneration*, Animals ; Bone and Bones ; Female ; Membranes, Artificial ; Rabbits ; Zoledronic Acid |
| مستخلص: | In recent years, biomaterial-based treatments, also called guided bone regeneration (GBR), which aim to establish a bone regeneration site and prevent the migration of gingival connective tissue and / or peripheral epithelium through the defective area during periodontal surgical procedures have come to the fore. In this report, we have developed a nanoparticle bearing thermosensitive in situ gel formulation of Pluronic F127 and poly(D,L-lactic acid) based membrane to reveal their utilization at GBR by in-vivo applications. In addition, the encouragement of the bone formation in defect area via inhibition of osteoclastic activity is intended by fabrication these biodegradable biomaterials at a lowered Zoledronic Acid (ZA) dose. Both of the developed materials remained stable under specified stability conditions (25 °C, 6 months) and provided the extended release profile of ZA. The in-vivo efficacy of nanoparticle bearing in situ gel formulation, membrane formulation and simultaneous application for guided bone regeneration was investigated in New Zealand female rabbits with a critical size defect of 0.5 × 0.5 cm in the tibia bone for eight weeks. Based on the histopathological findings, lamellar bone and primarily woven bone formations were observed after 8 weeks of post-implantation of both formulations, while fibrosis was detected only in the untreated group. Lamellar bone growth was remarkably achieved just four weeks after the simultaneous application of formulations. Consequently, the simultaneous application of ZA-membrane and ZA-nanoparticles loaded in-situ gel formulations offers enhanced and faster GBR therapy alternatives. Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. (Copyright © 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Guided bone regeneration; In-situ gel; Membrane; Nanoparticle; Zoledronic acid |
| المشرفين على المادة: | 0 (Biocompatible Materials) 0 (Membranes, Artificial) 6XC1PAD3KF (Zoledronic Acid) |
| تواريخ الأحداث: | Date Created: 20210513 Date Completed: 20211022 Latest Revision: 20211022 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.xphs.2021.05.002 |
| PMID: | 33984339 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1520-6017 |
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| DOI: | 10.1016/j.xphs.2021.05.002 |