دورية أكاديمية
White matter microstructure alterations in cortico-striatal networks are associated with parkinsonism in schizophrenia spectrum disorders.
| العنوان: | White matter microstructure alterations in cortico-striatal networks are associated with parkinsonism in schizophrenia spectrum disorders. |
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| المؤلفون: | Wasserthal J; Division of Medical Imaging Computing (MIC), German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany., Maier-Hein KH; Division of Medical Imaging Computing (MIC), German Cancer Research Center (DKFZ), Heidelberg, Germany; Section of Automated Image Analysis, Heidelberg University Hospital, Heidelberg, Germany., Neher PF; Division of Medical Imaging Computing (MIC), German Cancer Research Center (DKFZ), Heidelberg, Germany; Medical Faculty Heidelberg, Heidelberg University, Heidelberg, Germany., Wolf RC; Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany., Northoff G; Mind, Brain Imaging and Neuroethics Research Unit, The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada., Waddington JL; School of Pharmacy and Biomolecular Sciences, Royal College of Surgeons in Ireland, Dublin, Ireland., Kubera KM; Center for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Germany., Fritze S; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Harneit A; Department of Psychiatry and Psychotherapy, Research Group System Neuroscience in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Geiger LS; Department of Psychiatry and Psychotherapy, Research Group System Neuroscience in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Tost H; Department of Psychiatry and Psychotherapy, Research Group System Neuroscience in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany., Hirjak D; Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. Electronic address: dusan.hirjak@zi-mannheim.de. |
| المصدر: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology [Eur Neuropsychopharmacol] 2021 Sep; Vol. 50, pp. 64-74. Date of Electronic Publication: 2021 May 10. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: Netherlands NLM ID: 9111390 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-7862 (Electronic) Linking ISSN: 0924977X NLM ISO Abbreviation: Eur Neuropsychopharmacol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam : Elsevier, c1990- |
| مواضيع طبية MeSH: | Parkinsonian Disorders*/complications , Parkinsonian Disorders*/diagnostic imaging , Parkinsonian Disorders*/pathology , Schizophrenia*/complications , White Matter*/diagnostic imaging , White Matter*/pathology, Anisotropy ; Brain ; Gray Matter/pathology ; Humans |
| مستخلص: | The specific role of white matter (WM) microstructure in parkinsonism among patients with schizophrenia spectrum disorders (SSD) is largely unknown. To determine whether topographical alterations of WM microstructure contribute to parkinsonism in SSD patients, we examined healthy controls (HC, n=16) and SSD patients with and without parkinsonism, as defined by Simpson-Angus Scale total score of ≥4 (SSD-P, n=33) or <4 (SSD-nonP, n=62). We used whole brain tract-based spatial statistics (TBSS), tractometry (along tract statistics using TractSeg) and graph analytics (clustering coefficient (CCO), local betweenness centrality (BC)) to provide a framework of specific WM microstructural changes underlying parkinsonism in SSD. Using these methods, post hoc analyses showed (a) decreased fractional anisotrophy (FA), as measured via tractometry, in the corpus callosum, corticospinal tract and striato-fronto-orbital tract, and (b) increased CCO, as derived by graph analytics, in the left orbitofrontal cortex (OFC) and left superior frontal gyrus (SFG), in SSD-P patients when compared to SSD-nonP patients. Increased CCO in the left OFC and SFG was associated with SAS scores. These findings indicate the prominence of OFC alterations and aberrant connectivity with fronto-parietal regions and striatum in the pathogenesis of parkinsonism in SSD. This study further supports the notion of altered "bottom-up modulation" between basal ganglia and fronto-parietal regions in the pathobiology of parkinsonism, which may reflect an interaction between movement disorder intrinsic to SSD and antipsychotic drug-induced sensorimotor dysfunction. (Copyright © 2021. Published by Elsevier B.V.) |
| فهرسة مساهمة: | Keywords: DTI; Parkinsonism; Schizophrenia spectrum disorders; Sensorimotor domain; White matter |
| تواريخ الأحداث: | Date Created: 20210513 Date Completed: 20220411 Latest Revision: 20220411 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.euroneuro.2021.04.007 |
| PMID: | 33984810 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1873-7862 |
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| DOI: | 10.1016/j.euroneuro.2021.04.007 |