دورية أكاديمية
Evaluation of Growth Differentiation Factor-15 in Patients with or without Coronary Artery Disease.
| العنوان: | Evaluation of Growth Differentiation Factor-15 in Patients with or without Coronary Artery Disease. |
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| المؤلفون: | Hassanzadeh Daloee S; Division of Cardiovascular Medicine, Vascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. hasanzadedaloeem@mums.ac.ir., Nakhaei N; Division of Cardiovascular Medicine, Vascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. crc@mums.ac.ir., Hassanzadeh Daloee M; Division of Cardiovascular Medicine, Vascular Surgery Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. aminim1@mums.ac.ir., Mahmoodi M; Immunology Research Center, BuAli Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran. mahmoudim@mums.ac.ir., Barzegar-Amini M; Allergy Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. arc@mums.ac.ir. |
| المصدر: | Acta bio-medica : Atenei Parmensis [Acta Biomed] 2021 May 12; Vol. 92 (2), pp. e2021051. Date of Electronic Publication: 2021 May 12. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Mattioli 1885 Country of Publication: Italy NLM ID: 101295064 Publication Model: Electronic Cited Medium: Internet ISSN: 2531-6745 (Electronic) Linking ISSN: 03924203 NLM ISO Abbreviation: Acta Biomed Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2003- : Fidenza, Parma : Mattioli 1885 Original Publication: Parma, Italy : Ateneo parmense, [2002]- |
| مواضيع طبية MeSH: | Coronary Artery Disease*, Adult ; Aged ; Aged, 80 and over ; Biomarkers ; Cholesterol, HDL ; Cholesterol, LDL ; Cross-Sectional Studies ; Female ; Growth Differentiation Factor 15 ; Humans ; Male ; Middle Aged ; Risk Factors |
| مستخلص: | Background: Growth-differentiation factor-15 (GDF-15) is a distant member of the transforming growth factor-beta cytokine superfamily expressed in human atherosclerotic plaque macrophages. In this study, we sought to compare GDF-15 between patients with coronary artery disease and control group. Methods: In this cross-sectional study, 176 subjects were enrolled, consisted of 88 coronary artery disease patients (CAD group) and 88 non-CAD participants (control group. Clinical and demographic data, comprising of family history of CAD, history, and lifestyle factors, hypertension, diabetes, and some blood parameters (e.g. glucose, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C)), triglyceride, high-sensitivity C-reactive protein (hs-CRP)). Results: Mean age of the patients was 55.5±11.1 years (age range: 28-80 years). Of all the participants, 91 (51.7%) were male and 85 (48.3%) female. Hs-CRP, LDL-C, and GDF-15 levels were significantly higher in the CAD patients (P=0.091, P=0.008, and P<0.001, respectively). Total cholesterol, hematocrit, and hemoglobin were significantly higher in the controls (P=0.002, P=0.011, and P=0.055, respectively). The area under the receiver operating characteristic curve yielded the satisfactory result of 0.9 (95% CI, 0.8-0.9; P<0.001). The optimum cut-off value of GDF-15 was 1233 ng/L with 71% specificity and 71% sensitivity for CAD diagnosis. Conclusion: These data suggest that serum GDF-15 might be useful in prediction of CAD. |
| References: | Science. 2016 Oct 28;354(6311):472-477. (PMID: 27789842) Eur Heart J. 2009 Oct;30(19):2346-53. (PMID: 19561023) Cell Tissue Res. 2004 Nov;318(2):325-33. (PMID: 15459768) J Diabetes Res. 2015;2015:490842. (PMID: 26273671) Int J Cardiol. 2016 Oct 1;220:815-24. (PMID: 27394979) Circ Res. 2006 Feb 17;98(3):351-60. (PMID: 16397141) Int J Emerg Med. 2011 Jun 24;4:37. (PMID: 21702934) PLoS One. 2017 Aug 3;12(8):e0182314. (PMID: 28771550) Int Urol Nephrol. 2016 Jun;48(6):839-44. (PMID: 27043030) Front Immunol. 2017 Aug 29;8:1040. (PMID: 28900428) Crit Rev Clin Lab Sci. 2018 Jun;55(4):246-263. (PMID: 29663841) Eur Heart J. 2009 May;30(9):1057-65. (PMID: 19168526) Cardiovasc Ther. 2016 Jun;34(3):138-43. (PMID: 26996787) Clin Cancer Res. 2005 Jun 15;11(12):4610-9. (PMID: 15958647) Herz. 2009 Dec;34(8):594-9. (PMID: 20024638) JAMA Cardiol. 2018 Dec 1;3(12):1160-1166. (PMID: 30427997) Eur J Endocrinol. 2012 Nov;167(5):671-8. (PMID: 22918303) Ups J Med Sci. 2018 Jun;123(2):86-93. (PMID: 29714603) Circ Res. 2007 Jan 5;100(1):61-9. (PMID: 17138942) Mediators Inflamm. 2018 Jun 3;2018:8278039. (PMID: 29967567) Clin Chem. 2017 Jan;63(1):140-151. (PMID: 28062617) Circ Res. 2006 Feb 17;98(3):342-50. (PMID: 16397142) Curr Cardiol Rev. 2016;12(1):37-46. (PMID: 26750722) Clin Chem. 2012 Nov;58(11):1582-91. (PMID: 22997280) Crit Pathw Cardiol. 2018 Jun;17(2):105-110. (PMID: 29768320) Circulation. 2017 Jan 17;135(3):264-279. (PMID: 27832613) J Acquir Immune Defic Syndr. 2018 May 1;78(1):105-110. (PMID: 29419569) |
| المشرفين على المادة: | 0 (Biomarkers) 0 (Cholesterol, HDL) 0 (Cholesterol, LDL) 0 (GDF15 protein, human) 0 (Growth Differentiation Factor 15) |
| تواريخ الأحداث: | Date Created: 20210514 Date Completed: 20210625 Latest Revision: 20220531 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8182609 |
| DOI: | 10.23750/abm.v92i2.9267 |
| PMID: | 33988174 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2531-6745 |
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| DOI: | 10.23750/abm.v92i2.9267 |