دورية أكاديمية
Effects of Single-Dose Versus Hypofractionated Focused Radiation on Vertebral Body Structure and Biomechanical Integrity: Development of a Rabbit Radiation-Induced Vertebral Compression Fracture Model.
| العنوان: | Effects of Single-Dose Versus Hypofractionated Focused Radiation on Vertebral Body Structure and Biomechanical Integrity: Development of a Rabbit Radiation-Induced Vertebral Compression Fracture Model. |
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| المؤلفون: | Perdomo-Pantoja A; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Holmes C; Department of Chemical and Biomedical Engineering, Florida A&M University-Florida State University College of Engineering, Tallahassee, Florida., Lina IA; Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Liauw JA; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Puvanesarajah V; Department of Orthopedic Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Goh BC; Harvard Combined Orthopaedic Residency Program, Harvard Medical School, Boston, Massachusetts., Achebe CC; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland., Cottrill E; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland., Elder BD; Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota., Grayson WL; Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland., Redmond KJ; Department of Radiation Oncology and Molecular Radiation Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland., Hur SC; Department of Mechanical Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland., Witham TF; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, Maryland. Electronic address: twitham2@jhmi.edu. |
| المصدر: | International journal of radiation oncology, biology, physics [Int J Radiat Oncol Biol Phys] 2021 Oct 01; Vol. 111 (2), pp. 528-538. Date of Electronic Publication: 2021 May 11. |
| نوع المنشور: | Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier, Inc Country of Publication: United States NLM ID: 7603616 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-355X (Electronic) Linking ISSN: 03603016 NLM ISO Abbreviation: Int J Radiat Oncol Biol Phys Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York, NY : Elsevier, Inc Original Publication: Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: | Disease Models, Animal* , Radiation Dose Hypofractionation*, Fractures, Compression/*etiology , Lumbar Vertebrae/*radiation effects , Radiosurgery/*adverse effects , Spinal Fractures/*etiology, Animals ; Biomechanical Phenomena ; Male ; Rabbits ; Spinal Neoplasms/radiotherapy ; Vertebral Body/radiation effects |
| مستخلص: | Purpose: Vertebral compression fracture is a common complication of spinal stereotactic body radiation therapy. Development of an in vivo model is crucial to fully understand how focal radiation treatment affects vertebral integrity and biology at various dose fractionation regimens. We present a clinically relevant animal model to analyze the effects of localized, high-dose radiation on vertebral microstructure and mechanical integrity. Using this model, we test the hypothesis that fractionation of radiation dosing can reduce focused radiation therapy's harmful effects on the spine. Methods and Materials: The L5 vertebra of New Zealand white rabbits was treated with either a 24-Gy single dose of focused radiation or 3 fractionated 8-Gy doses over 3 consecutive days via the Small Animal Radiation Research Platform. Nonirradiated rabbits were used as controls. Rabbits were euthanized 6 months after irradiation, and their lumbar vertebrae were harvested for radiologic, histologic, and biomechanical testing. Results: Localized single-dose radiation led to decreased vertebral bone volume and trabecular number and a subsequent increase in trabecular spacing and thickness at L5. Hypofractionation of the radiation dose similarly led to reduced trabecular number and increased trabecular spacing and thickness, yet it preserved normalized bone volume. Single-dose irradiated vertebrae displayed lower fracture loads and stiffness compared with those receiving hypofractionated irradiation and with controls. The hypofractionated and control groups exhibited similar fracture load and stiffness. For all vertebral samples, bone volume, trabecular number, and trabecular spacing were correlated with fracture loads and Young's modulus (P < .05). Hypocellularity was observed in the bone marrow of both irradiated groups, but osteogenic features were conserved in only the hypofractionated group. Conclusions: Single-dose focal irradiation showed greater detrimental effects than hypofractionation on the microarchitectural, cellular, and biomechanical characteristics of irradiated vertebral bodies. Correlation between radiologic measurements and biomechanical properties supported the reliability of this animal model of radiation-induced vertebral compression fracture, a finding that can be applied to future studies of preventative measures. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| تواريخ الأحداث: | Date Created: 20210514 Date Completed: 20210929 Latest Revision: 20210929 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1016/j.ijrobp.2021.04.050 |
| PMID: | 33989720 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1879-355X |
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| DOI: | 10.1016/j.ijrobp.2021.04.050 |