دورية أكاديمية
Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018.
| العنوان: | Genomic investigation of a dengue virus outbreak in Thiès, Senegal, in 2018. |
|---|---|
| المؤلفون: | Gaye A; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Ndiaye T; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Sy M; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Deme AB; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Thiaw AB; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Sene A; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Ndiaye C; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Diedhiou Y; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Mbaye AM; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Ndiaye I; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Tomkins-Tinch C; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA, USA., Gomis JF; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Badiane AS; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., MacInnis B; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Park DJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA., Ndiaye M; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal., Sy N; Service de Lutte AntiParasitaire, Thiès, Senegal., Sabeti PC; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA, USA.; Department of Immunology and Infectious Disease, Harvard School of Public Health, Boston, MA, USA.; Howard Hughes Medical Institute (HHMI), Chevy Chase, MD, USA., Siddle KJ; Broad Institute of MIT and Harvard, Cambridge, MA, USA.; Department of Organismal and Evolutionary Biology, Harvard University, Cambridge, MA, USA., Ndiaye D; Laboratoire de Parasitologie-Mycologie, Hôpital Aristide le Dantec, Université Cheikh Anta Diop de Dakar, BP 16477, Dakar, Senegal. daouda.ndiaye@ucad.edu.sn. |
| المصدر: | Scientific reports [Sci Rep] 2021 May 14; Vol. 11 (1), pp. 10321. Date of Electronic Publication: 2021 May 14. |
| نوع المنشور: | Journal Article; Observational Study; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: London : Nature Publishing Group, copyright 2011- |
| مواضيع طبية MeSH: | Dengue/*virology , Dengue Virus/*genetics , Disease Outbreaks/*statistics & numerical data, Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; DNA, Viral/isolation & purification ; Dengue/blood ; Dengue/diagnosis ; Dengue/epidemiology ; Dengue Virus/isolation & purification ; Female ; Genome, Viral ; Humans ; Male ; Middle Aged ; Molecular Epidemiology ; Phylogeny ; Senegal/epidemiology ; Serogroup ; Young Adult |
| مستخلص: | Dengue virus is a major and rapidly growing public health concern in tropic and subtropic regions across the globe. In late 2018, Senegal experienced its largest dengue virus outbreak to date, covering several regions. However, little is known about the genetic diversity of dengue virus (DENV) in Senegal. Here we report complete viral genomes from 17 previously undetected DENV cases from the city of Thiès. In total we identified 19 cases of DENV in a cohort of 198 individuals with fever collected in October and November 2018. We detected 3 co-circulating serotypes; DENV 3 was the most frequent accounting for 11/17 sequences (65%), 4 (23%) were DENV2 and 2 (12%) were DENV1. Sequences were most similar to recent sequences from West Africa, suggesting ongoing local circulation of viral populations; however, detailed inference is limited by the scarcity of available genomic data. We did not find clear associations with reported clinical signs or symptoms, highlighting the importance of testing for diagnosing febrile diseases. Overall, these findings expand the known range of DENV in Senegal, and underscore the need for better genomic characterization of DENV in West Africa. |
| References: | J Infect Dis. 2018 Jan 30;217(4):622-627. (PMID: 29325146) J Vis Exp. 2016 Jul 02;(113):. (PMID: 27403729) Nat Biotechnol. 2011 May 15;29(7):644-52. (PMID: 21572440) Int J Infect Dis. 2020 Feb;91:129-136. (PMID: 31821892) Emerg Infect Dis. 2011 Aug;17(8):1349-54. (PMID: 21801609) Trop Med Health. 2011 Dec;39(4 Suppl):3-11. (PMID: 22500131) Genome Biol. 2018 Nov 16;19(1):198. (PMID: 30445993) Sci Rep. 2017 Nov 9;7(1):15216. (PMID: 29123142) Clin Epidemiol. 2013 Aug 20;5:299-309. (PMID: 23990732) Science. 2017 Nov 17;358(6365):929-932. (PMID: 29097492) Annu Rev Virol. 2016 Sep 29;3(1):173-195. (PMID: 27501264) Malar J. 2016 Jan 28;15:47. (PMID: 26821709) Virus Evol. 2018 Jun 08;4(1):vey016. (PMID: 29942656) Biomed Res Int. 2017;2017:4248756. (PMID: 28626758) Emerg Infect Dis. 2014 Mar;20(3):456-9. (PMID: 24572297) Travel Med Infect Dis. 2019 Mar - Apr;28:107-108. (PMID: 30408524) Emerg Infect Dis. 2017 Feb;23(2):272-275. (PMID: 28098525) Nature. 2013 Apr 25;496(7446):504-7. (PMID: 23563266) Science. 2017 Mar 24;355(6331):1302-1306. (PMID: 28336667) PLoS Negl Trop Dis. 2019 Feb 13;13(2):e0007043. (PMID: 30759080) J Travel Med. 2019 Oct 14;26(7):. (PMID: 30407572) Lancet Infect Dis. 2018 Jun;18(6):684-695. (PMID: 29523497) Am J Trop Med Hyg. 2008 Aug;79(2):218-29. (PMID: 18689628) J Virol. 2013 Apr;87(8):4609-22. (PMID: 23408612) Diagnostics (Basel). 2020 Jun 16;10(6):. (PMID: 32560073) Nat Microbiol. 2019 Jan;4(1):10-19. (PMID: 30546099) Mol Biol Evol. 2018 Feb 1;35(2):518-522. (PMID: 29077904) Mol Biol Evol. 2015 Jan;32(1):268-74. (PMID: 25371430) Am J Trop Med Hyg. 2017 Sep;97(3_Suppl):89-98. (PMID: 28990913) Emerg Infect Dis. 2019 Apr;25(4):784-787. (PMID: 30882320) |
| معلومات مُعتمدة: | U01 AI151812 United States AI NIAID NIH HHS; U54 HG007480 United States HG NHGRI NIH HHS; United States HHMI Howard Hughes Medical Institute |
| المشرفين على المادة: | 0 (DNA, Viral) |
| تواريخ الأحداث: | Date Created: 20210515 Date Completed: 20211029 Latest Revision: 20211029 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8121849 |
| DOI: | 10.1038/s41598-021-89070-1 |
| PMID: | 33990632 |
| قاعدة البيانات: | MEDLINE |
Find this article in full text from Springer Verlag. 
Full Text Finder | تدمد: | 2045-2322 |
|---|---|
| DOI: | 10.1038/s41598-021-89070-1 |