دورية أكاديمية
أعرض في EDS

ComparativeStudyofCRHMicroinjections Into PVN and CeA Nuclei on Food Intake, Ghrelin, Leptin, and Glucose Levels in Acute Stressed Rats.

التفاصيل البيبلوغرافية
العنوان: ComparativeStudyofCRHMicroinjections Into PVN and CeA Nuclei on Food Intake, Ghrelin, Leptin, and Glucose Levels in Acute Stressed Rats.
المؤلفون: Radahmadi M; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Izadi MS; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Rayatpour A; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Ghasemi M; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
المصدر: Basic and clinical neuroscience [Basic Clin Neurosci] 2021 Jan-Feb; Vol. 12 (1), pp. 133-148. Date of Electronic Publication: 2021 Jan 01.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Iran University of Medical Sciences Country of Publication: Iran NLM ID: 101575211 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2008-126X (Print) Linking ISSN: 2008126X NLM ISO Abbreviation: Basic Clin Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: Tehran : Iran University of Medical Sciences
Original Publication: Tehran : Tehran University of Medical Sciences
مستخلص: Introduction: Corticotropin-Releasing Hormone (CRH) is involved in stress and energy homeostasis. On the other hand, CRH receptors also exist within the paraventricular nucleus (PVN) and Central Amygdala (CeA) nuclei. The present study compared the effect of CRH microinjections into PVN and CeA on three consecutive hours and cumulative food intake, internal regulatory factors of food intake, such as serum leptin and ghrelin, as well as blood glucose levels in rats under different acute psychological (Social Stress [SS] and Isolation Stress [IS] group) stresses.
Methods: Sixty-six male Wistar rats were randomly allocated to 11 groups: Control, Sham, CRH-PVN, CRH-CeA, SS, IS, SS-CRH-PVN, SS-CRH-CeA, IS-CRH-PVN, and IS-CRH-CeA groups. The CRH (2 µg/kg in 0.5 µL saline) was injected into PVN and CeA nuclei in rats under everyday, acute social stress and isolation stress conditions.
Results: Acute isolation and social stresses did not affect cumulative food intake. Whereas isolation stress led to changes in both leptin and glucose levels, social stress reduced only glucose levels. Cumulative food intake significantly decreased under acute CRH injection into the CeA and particularly into the PVN. Blood glucose significantly reduced in all the groups receiving CRH into their CeA.
Conclusion: The PVN played a more important role compared to CeA on food intake. These nuclei probably employ different mechanisms for their effects on food intake. Besides, it seems that exogenously CRH injection into the PVN probably had a more anorectic effect than naturally activated CRH by stresses. Acute isolation stress had a greater impact than social stress on leptin level and cumulative food intake. Thus, elevated food intake related to leptin compared to ghrelin and glucose levels in the CRH-PVN group under acute social stress.
Competing Interests: Conflict of interest The authors declared no conflict of interest.
(Copyright© 2021 Iranian Neuroscience Society.)
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فهرسة مساهمة: Keywords: Central amygdala; Corticotropin-releasing hormone; Food intake; Isolation stress; Paraventricular; Social stress
تواريخ الأحداث: Date Created: 20210517 Latest Revision: 20220423
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8114857
DOI: 10.32598/bcn.12.1.2346.1
PMID: 33995935
قاعدة البيانات: MEDLINE
الوصف
تدمد:2008-126X
DOI:10.32598/bcn.12.1.2346.1