دورية أكاديمية
ComparativeStudyofCRHMicroinjections Into PVN and CeA Nuclei on Food Intake, Ghrelin, Leptin, and Glucose Levels in Acute Stressed Rats.
العنوان: | ComparativeStudyofCRHMicroinjections Into PVN and CeA Nuclei on Food Intake, Ghrelin, Leptin, and Glucose Levels in Acute Stressed Rats. |
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المؤلفون: | Radahmadi M; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Izadi MS; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Rayatpour A; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran., Ghasemi M; Department of Physiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. |
المصدر: | Basic and clinical neuroscience [Basic Clin Neurosci] 2021 Jan-Feb; Vol. 12 (1), pp. 133-148. Date of Electronic Publication: 2021 Jan 01. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Iran University of Medical Sciences Country of Publication: Iran NLM ID: 101575211 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2008-126X (Print) Linking ISSN: 2008126X NLM ISO Abbreviation: Basic Clin Neurosci Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: Tehran : Iran University of Medical Sciences Original Publication: Tehran : Tehran University of Medical Sciences |
مستخلص: | Introduction: Corticotropin-Releasing Hormone (CRH) is involved in stress and energy homeostasis. On the other hand, CRH receptors also exist within the paraventricular nucleus (PVN) and Central Amygdala (CeA) nuclei. The present study compared the effect of CRH microinjections into PVN and CeA on three consecutive hours and cumulative food intake, internal regulatory factors of food intake, such as serum leptin and ghrelin, as well as blood glucose levels in rats under different acute psychological (Social Stress [SS] and Isolation Stress [IS] group) stresses. Methods: Sixty-six male Wistar rats were randomly allocated to 11 groups: Control, Sham, CRH-PVN, CRH-CeA, SS, IS, SS-CRH-PVN, SS-CRH-CeA, IS-CRH-PVN, and IS-CRH-CeA groups. The CRH (2 µg/kg in 0.5 µL saline) was injected into PVN and CeA nuclei in rats under everyday, acute social stress and isolation stress conditions. Results: Acute isolation and social stresses did not affect cumulative food intake. Whereas isolation stress led to changes in both leptin and glucose levels, social stress reduced only glucose levels. Cumulative food intake significantly decreased under acute CRH injection into the CeA and particularly into the PVN. Blood glucose significantly reduced in all the groups receiving CRH into their CeA. Conclusion: The PVN played a more important role compared to CeA on food intake. These nuclei probably employ different mechanisms for their effects on food intake. Besides, it seems that exogenously CRH injection into the PVN probably had a more anorectic effect than naturally activated CRH by stresses. Acute isolation stress had a greater impact than social stress on leptin level and cumulative food intake. Thus, elevated food intake related to leptin compared to ghrelin and glucose levels in the CRH-PVN group under acute social stress. Competing Interests: Conflict of interest The authors declared no conflict of interest. (Copyright© 2021 Iranian Neuroscience Society.) |
References: | Psychoneuroendocrinology. 2007 Sep-Nov;32(8-10):966-80. (PMID: 17825994) Physiol Behav. 2015 Feb;139:459-67. (PMID: 25481360) Front Neuroendocrinol. 2012 Jan;33(1):67-84. (PMID: 21871477) Adv Biomed Res. 2018 Aug 29;7:118. (PMID: 30211131) J Psychosom Res. 2002 Oct;53(4):865-71. (PMID: 12377295) J Neuroendocrinol. 1996 Feb;8(2):103-12. (PMID: 8868257) Nat Neurosci. 2014 Sep;17(9):1240-8. (PMID: 25064852) Dialogues Clin Neurosci. 2002 Mar;4(1):31-46. (PMID: 22033745) Brain Res. 2002 Feb 1;926(1-2):181-5. (PMID: 11814422) Eur J Pharmacol. 2016 Feb 5;772:43-50. (PMID: 26712378) Basic Res Cardiol. 2011 May;106(3):473-83. (PMID: 21287352) Brain Res Brain Res Rev. 2001 Dec;38(1-2):247-89. (PMID: 11750934) Neuropeptides. 2004 Aug;38(4):201-11. (PMID: 15337372) Learn Mem. 2010 Oct 01;17(10):531-8. (PMID: 20889725) Peptides. 2000 Mar;21(3):345-51. (PMID: 10793215) J Clin Endocrinol Metab. 2002 Jan;87(1):240-4. (PMID: 11788653) Cell. 2001 Feb 23;104(4):531-43. (PMID: 11239410) Health Commun. 2017 Aug;32(8):1039-1042. (PMID: 27463703) Front Endocrinol (Lausanne). 2014 Apr 24;5:58. (PMID: 24795698) Psychoneuroendocrinology. 2015 Mar;53:49-59. (PMID: 25591115) Ann N Y Acad Sci. 2009 Oct;1179:106-19. (PMID: 19906235) Brain Res. 2005 Jun 28;1048(1-2):131-7. (PMID: 15919058) Metabolism. 2016 May;65(5):699-713. (PMID: 27085777) Peptides. 2013 Jul;45:9-14. (PMID: 23628372) Behav Brain Res. 2015 Apr 1;282:209-17. (PMID: 25601576) Regul Pept. 2006 May 15;134(2-3):114-7. (PMID: 16540188) Physiol Behav. 2011 Oct 24;104(5):675-83. (PMID: 21787797) Peptides. 2001 May;22(5):713-24. (PMID: 11337084) Physiol Behav. 2011 Jul 6;103(5):487-92. (PMID: 21497614) Psychoneuroendocrinology. 2014 Sep;47:232-40. (PMID: 24954303) Physiol Behav. 2007 Jul 24;91(4):449-58. (PMID: 17543357) Ann N Y Acad Sci. 2003 Apr;985:251-62. (PMID: 12724163) Int J Obes Relat Metab Disord. 2000 Jun;24 Suppl 2:S36-9. (PMID: 10997606) Neuropsychopharmacology. 2005 Sep;30(9):1589-97. (PMID: 15770236) J Exp Biol. 2012 Jul 1;215(Pt 13):2273-82. (PMID: 22675188) Physiol Behav. 2004 Jul;81(5):781-93. (PMID: 15234184) Neurobiol Learn Mem. 2007 Jan;87(1):67-71. (PMID: 16997585) Brain Res. 1988 Mar 8;443(1-2):63-9. (PMID: 2834018) Inflammopharmacology. 2017 Feb;25(1):69-79. (PMID: 27853890) Br J Nutr. 2007 Jul;98(1):17-25. (PMID: 17524176) Physiol Behav. 1985 Mar;34(3):359-61. (PMID: 3892557) Am J Physiol Regul Integr Comp Physiol. 2002 Dec;283(6):R1321-6. (PMID: 12429558) Neuropharmacology. 2012 Jul;63(1):3-17. (PMID: 22313528) Pharmacol Rev. 1991 Dec;43(4):425-73. (PMID: 1775506) Annu Rev Physiol. 2009;71:219-39. (PMID: 18928406) J Neuroendocrinol. 2001 Feb;13(2):113-28. (PMID: 11168837) Nutrition. 2007 Nov-Dec;23(11-12):887-94. (PMID: 17869482) Life Sci. 2006 Mar 13;78(16):1857-62. (PMID: 16289237) Behav Brain Res. 2013 Nov 1;256:636-45. (PMID: 24050889) Biochem Biophys Res Commun. 2004 Jan 16;313(3):635-41. (PMID: 14697239) J Chem Neuroanat. 2013 Dec;54:25-33. (PMID: 23774011) Peptides. 2002 Dec;23(12):2283-306. (PMID: 12535710) Brain Res. 2013 Nov 20;1539:73-86. (PMID: 24096214) Nat Rev Neurosci. 2002 Jul;3(7):563-73. (PMID: 12094212) J Exp Biol. 2017 Jan 1;220(Pt 1):92-102. (PMID: 28057832) Horm Metab Res. 2010 Sep;42(10):746-53. (PMID: 20665427) Pharmacogn Mag. 2015 Oct;11(Suppl 3):S388-96. (PMID: 26929572) Front Neurosci. 2013 Jun 17;7:109. (PMID: 23785312) Curr Opin Pharmacol. 2009 Dec;9(6):787-93. (PMID: 19758844) |
فهرسة مساهمة: | Keywords: Central amygdala; Corticotropin-releasing hormone; Food intake; Isolation stress; Paraventricular; Social stress |
تواريخ الأحداث: | Date Created: 20210517 Latest Revision: 20220423 |
رمز التحديث: | 20240628 |
مُعرف محوري في PubMed: | PMC8114857 |
DOI: | 10.32598/bcn.12.1.2346.1 |
PMID: | 33995935 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2008-126X |
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DOI: | 10.32598/bcn.12.1.2346.1 |