دورية أكاديمية
New insights into the digestion and bioavailability of a high-melting-temperature solid triacylglycerol fraction in bovine milk fat.
| العنوان: | New insights into the digestion and bioavailability of a high-melting-temperature solid triacylglycerol fraction in bovine milk fat. |
|---|---|
| المؤلفون: | Ren Q; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, Heilongjiang, China. maying@hit.edu.cn., Fu L; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, Heilongjiang, China. maying@hit.edu.cn., Dudu OE; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, Heilongjiang, China. maying@hit.edu.cn., Zhang R; The Academy of Quality Inspection in Heilongjiang Province, Harbin 150023, Heilongjiang, China., Liu H; Syncho International Health Management Co., Ltd, Chengdu 610044, Sichuan, China and Dairy Nutrition and Function Key Laboratory of Sichuan Province, Chengdu 610000, Sichuan, China., Zheng Z; Institute of Quartermaster Engineering and Technology, Institute of System Engineering, Academy of Military Sciences, Beijing 100010, China., Ma Y; School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, Heilongjiang, China. maying@hit.edu.cn. |
| المصدر: | Food & function [Food Funct] 2021 Jun 21; Vol. 12 (12), pp. 5274-5286. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Royal Society of Chemistry Country of Publication: England NLM ID: 101549033 Publication Model: Print Cited Medium: Internet ISSN: 2042-650X (Electronic) Linking ISSN: 20426496 NLM ISO Abbreviation: Food Funct Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Cambridge : Royal Society of Chemistry |
| مواضيع طبية MeSH: | Digestion* , Temperature*, Glycolipids/*metabolism , Glycoproteins/*metabolism , Lipid Droplets/*metabolism , Milk/*metabolism , Triglycerides/*metabolism, Acetyl-CoA Carboxylase/metabolism ; Adipose Tissue/metabolism ; Animals ; Biological Availability ; Cattle ; Lipolysis/drug effects ; Liver/pathology ; Male ; Models, Animal ; Peptide YY ; Postprandial Period ; Rats ; Sterol Esterase/metabolism |
| مستخلص: | Clarifying the health risks associated with the consumption of high-melting-temperature solid triacylglycerol (TAG) from milk fat has profound significance for the nutritional evaluation and development of new dairy products. Our previous work effectively separated butterfat into solid/liquid fractions (30S and 30L) at 30 °C and successfully reconstituted milk fat globules (MFGs) with these fractions. The current study examined the postprandial digestive and daily metabolic properties of a high-melting-temperature solid TAG fraction by performing animal experiments (rats) with 30S-reconstituted MFG emulsion gavage for 240 min and 30S-containing diet administration for 4 weeks. Compared to the consumption of whole butterfat, 30S consumption altered apolipoprotein levels and did not lead to dyslipidaemia in the rats. Conversely, 30S administration induced significant body weight loss by enhancing satiety signals (glucagon-like peptide 1, GLP-1; cholecystokinin, CCK; and peptide YY, PYY), increasing faecal losses, and upregulating the level of hepatic lipolysis-associated enzymes (hormone-sensitive lipase, HSL; adipose triglyceride lipase, ATGL; and protein kinase A, PKA). The 30S diet efficiently improved adipocyte hypertrophy and reduced fat accumulation by downregulating the level of acetyl-CoA carboxylase (ACC) in adipose tissue. This study is of relevance to nutrition science and the dairy industry. |
| المشرفين على المادة: | 0 (Glycolipids) 0 (Glycoproteins) 0 (Triglycerides) 0 (milk fat globule) 106388-42-5 (Peptide YY) EC 3.1.1.13 (Sterol Esterase) EC 6.4.1.2 (Acetyl-CoA Carboxylase) |
| تواريخ الأحداث: | Date Created: 20210519 Date Completed: 20211123 Latest Revision: 20211123 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1039/d1fo00259g |
| PMID: | 34008635 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2042-650X |
|---|---|
| DOI: | 10.1039/d1fo00259g |