دورية أكاديمية
Blood pressure, hematologic and biochemical changes following L-arginine supplementation in children with sickle cell anaemia already on hydroxyurea therapy.
| العنوان: | Blood pressure, hematologic and biochemical changes following L-arginine supplementation in children with sickle cell anaemia already on hydroxyurea therapy. |
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| المؤلفون: | Temiye EO; temiyeeo@hhlhhlll.com., Eimunjeze OP; Eimunjezeop@knlnlnlnll.com., Ogungbemi SI; igigigigigig@bbbk.com., Jaja SI; sjaja@unilag.edu.ng. |
| المصدر: | Nigerian journal of physiological sciences : official publication of the Physiological Society of Nigeria [Niger J Physiol Sci] 2020 Dec 31; Vol. 35 (2), pp. 131-134. Date of Electronic Publication: 2020 Dec 31. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Physiological Society of Nigeria Country of Publication: Nigeria NLM ID: 8811109 Publication Model: Electronic Cited Medium: Internet ISSN: 0794-859X (Print) Linking ISSN: 0794859X NLM ISO Abbreviation: Niger J Physiol Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Benin City, Nigeria : Physiological Society of Nigeria |
| مواضيع طبية MeSH: | Anemia, Sickle Cell*/drug therapy , Hydroxyurea*, Arginine ; Blood Pressure ; Child ; Dietary Supplements ; Humans |
| مستخلص: | Hydroxyurea is an approved therapy in the management of children suffering from sickle cell disease (SCD). In adults co-administration of hydroxyurea and L-Arginine in adult sufferers of SCD had shown some benefits. This study examined the effect of co-administration of hydroxyurea (15-35mg/kg/day) and L-Arginine (500 mg/day) for 6 weeks on blood pressure, haematological parameters, liver and antioxidant enzymes levels. The levels of these parameters when the subjects were on hydroxyurea alone were taken as control values. Results showed that the combined therapy (HU + L-Arginine) decreased SBP, DBP, MAP and PP (p <0.01 in each case) but increased %HbF, Hb and PCV (p< o.001 in each case). It elevated CAT, SOD, GPX (p < 0.001 in each case) but depressed MDA, AST, ALT and ALP (p < 0.001 in each case). The study shows that L-Arginine used as an adjunct to hydroxyurea therapy may be beneficial to children suffering from sickle cell anaemia. |
| المشرفين على المادة: | 94ZLA3W45F (Arginine) X6Q56QN5QC (Hydroxyurea) |
| تواريخ الأحداث: | Date Created: 20210519 Date Completed: 20211028 Latest Revision: 20211028 |
| رمز التحديث: | 20231215 |
| PMID: | 34009196 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0794-859X |
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