دورية أكاديمية
أعرض في EDS

Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma.

التفاصيل البيبلوغرافية
العنوان: Caspase-8 deficiency induces a switch from TLR3 induced apoptosis to lysosomal cell death in neuroblastoma.
المؤلفون: Locquet MA; Childhood Cancers and Cell Death Laboratory, Cancer Research Center of Lyon (CRCL), INSERM 1052, CNRS 5286, Lyon, France., Ichim G; Cancer Cell Death Laboratory, Part of LabEx DEVweCAN, Cancer Initiation and Tumoral Cell Identity Department, CRCL, Lyon, France., Bisaccia J; Childhood Cancers and Cell Death Laboratory, Cancer Research Center of Lyon (CRCL), INSERM 1052, CNRS 5286, Lyon, France., Dutour A; Childhood Cancers and Cell Death Laboratory, Cancer Research Center of Lyon (CRCL), INSERM 1052, CNRS 5286, Lyon, France., Lebecque S; Childhood Cancers and Cell Death Laboratory, Cancer Research Center of Lyon (CRCL), INSERM 1052, CNRS 5286, Lyon, France.; Service D'Anatomie Pathologique, Hospices Civils de Lyon, Hôpital Lyon Sud, Pierre-Bénite, France., Castets M; Childhood Cancers and Cell Death Laboratory, Cancer Research Center of Lyon (CRCL), INSERM 1052, CNRS 5286, Lyon, France. marie.castets@lyon.unicancer.fr., Weber K; Childhood Cancers and Cell Death Laboratory, Cancer Research Center of Lyon (CRCL), INSERM 1052, CNRS 5286, Lyon, France. katrin.weber@lyon.unicancer.fr.
المصدر: Scientific reports [Sci Rep] 2021 May 19; Vol. 11 (1), pp. 10609. Date of Electronic Publication: 2021 May 19.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Apoptosis*/drug effects, Caspase 8/*metabolism , Neuroblastoma/*metabolism , Neuroblastoma/*pathology , Toll-Like Receptor 3/*metabolism, Cell Line, Tumor ; Enzyme Activation/drug effects ; Humans ; Interferon Type I/pharmacology ; Intracellular Membranes/drug effects ; Intracellular Membranes/metabolism ; Lysosomes/drug effects ; Lysosomes/metabolism ; Necroptosis/drug effects ; Permeability/drug effects ; Poly I-C/pharmacology
مستخلص: In cancer cells only, TLR3 acquires death receptor properties by efficiently triggering the extrinsic pathway of apoptosis with Caspase-8 as apical protease. Here, we demonstrate that in the absence of Caspase-8, activation of TLR3 can trigger a form of programmed cell death, which is distinct from classical apoptosis. When TLR3 was activated in the Caspase-8 negative neuroblastoma cell line SH-SY5Y, cell death was accompanied by lysosomal permeabilization. Despite caspases being activated, lysosomal permeabilization as well as cell death were not affected by blocking caspase-activity, positioning lysosomal membrane permeabilization (LMP) upstream of caspase activation. Taken together, our data suggest that LMP with its deadly consequences represents a "default" death mechanism in cancer cells, when Caspase-8 is absent and apoptosis cannot be induced.
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المشرفين على المادة: 0 (Interferon Type I)
0 (Toll-Like Receptor 3)
EC 3.4.22.- (Caspase 8)
O84C90HH2L (Poly I-C)
تواريخ الأحداث: Date Created: 20210520 Date Completed: 20211028 Latest Revision: 20211028
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8134575
DOI: 10.1038/s41598-021-89793-1
PMID: 34011952
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-89793-1