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Plume Dynamics Structure the Spatiotemporal Activity of Mitral/Tufted Cell Networks in the Mouse Olfactory Bulb.

التفاصيل البيبلوغرافية
العنوان: Plume Dynamics Structure the Spatiotemporal Activity of Mitral/Tufted Cell Networks in the Mouse Olfactory Bulb.
المؤلفون: Lewis SM; Department of Psychology, University of Washington, Seattle, WA, United States., Xu L; Department of Psychology, University of Washington, Seattle, WA, United States., Rigolli N; Dipartimento di Fisica, Istituto Nazionale Fisica Nucleare (INFN) Genova, Universitá di Genova, Genova, Italy.; CNRS, Institut de Physique de Nice, Université Côte d'Azur, Nice, France., Tariq MF; Graduate Program in Neuroscience, University of Washington, Seattle, WA, United States., Suarez LM; Department of Psychology, University of Washington, Seattle, WA, United States., Stern M; Department of Applied Mathematics, University of Washington, Seattle, WA, United States., Seminara A; CNRS, Institut de Physique de Nice, Université Côte d'Azur, Nice, France., Gire DH; Department of Psychology, University of Washington, Seattle, WA, United States.
المصدر: Frontiers in cellular neuroscience [Front Cell Neurosci] 2021 Apr 30; Vol. 15, pp. 633757. Date of Electronic Publication: 2021 Apr 30 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Frontiers Research Foundation Country of Publication: Switzerland NLM ID: 101477935 Publication Model: eCollection Cited Medium: Print ISSN: 1662-5102 (Print) Linking ISSN: 16625102 NLM ISO Abbreviation: Front Cell Neurosci Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne, Switzerland : Frontiers Research Foundation, 2007-
مستخلص: Although mice locate resources using turbulent airborne odor plumes, the stochasticity and intermittency of fluctuating plumes create challenges for interpreting odor cues in natural environments. Population activity within the olfactory bulb (OB) is thought to process this complex spatial and temporal information, but how plume dynamics impact odor representation in this early stage of the mouse olfactory system is unknown. Limitations in odor detection technology have made it difficult to measure plume fluctuations while simultaneously recording from the mouse's brain. Thus, previous studies have measured OB activity following controlled odor pulses of varying profiles or frequencies, but this approach only captures a subset of features found within olfactory plumes. Adequately sampling this feature space is difficult given a lack of knowledge regarding which features the brain extracts during exposure to natural olfactory scenes. Here we measured OB responses to naturally fluctuating odor plumes using a miniature, adapted odor sensor combined with wide-field GCaMP6f signaling from the dendrites of mitral and tufted (MT) cells imaged in olfactory glomeruli of head-fixed mice. We precisely tracked plume dynamics and imaged glomerular responses to this fluctuating input, while varying flow conditions across a range of ethologically-relevant values. We found that a consistent portion of MT activity in glomeruli follows odor concentration dynamics, and the strongest responding glomeruli are the best at following fluctuations within odor plumes. Further, the reliability and average response magnitude of glomerular populations of MT cells are affected by the flow condition in which the animal samples the plume, with the fidelity of plume following by MT cells increasing in conditions of higher flow velocity where odor dynamics result in intermittent whiffs of stronger concentration. Thus, the flow environment in which an animal encounters an odor has a large-scale impact on the temporal representation of an odor plume in the OB. Additionally, across flow conditions odor dynamics are a major driver of activity in many glomerular networks. Taken together, these data demonstrate that plume dynamics structure olfactory representations in the first stage of odor processing in the mouse olfactory system.
Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
(Copyright © 2021 Lewis, Xu, Rigolli, Tariq, Suarez, Stern, Seminara and Gire.)
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معلومات مُعتمدة: R00 DC013305 United States DC NIDCD NIH HHS; R01 DC018789 United States DC NIDCD NIH HHS
فهرسة مساهمة: Keywords: natural sensing; olfaction; olfactory navigation; plume dynamics; population dynamics; sensory processing
تواريخ الأحداث: Date Created: 20210520 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC8127944
DOI: 10.3389/fncel.2021.633757
PMID: 34012385
قاعدة البيانات: MEDLINE
الوصف
تدمد:1662-5102
DOI:10.3389/fncel.2021.633757