دورية أكاديمية
أعرض في EDS

Developing functional network connectivity of the dorsal anterior cingulate cortex mediates externalizing psychopathology in adolescents with child neglect.

التفاصيل البيبلوغرافية
العنوان: Developing functional network connectivity of the dorsal anterior cingulate cortex mediates externalizing psychopathology in adolescents with child neglect.
المؤلفون: Silveira S; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States., Boney S; East Carolina University Brody School of Medicine, Greenville, NC, United States., Tapert SF; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States., Mishra J; Department of Psychiatry, University of California San Diego, La Jolla, CA, United States. Electronic address: jymishra@health.ucsd.edu.
المصدر: Developmental cognitive neuroscience [Dev Cogn Neurosci] 2021 Jun; Vol. 49, pp. 100962. Date of Electronic Publication: 2021 May 13.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101541838 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-9307 (Electronic) Linking ISSN: 18789293 NLM ISO Abbreviation: Dev Cogn Neurosci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier
مواضيع طبية MeSH: Child Abuse* , Gyrus Cinguli* , Mental Disorders*, Adolescent ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Psychopathology ; Young Adult
مستخلص: Childhood adversity has been associated with elevated risk for psychopathology. We investigated whether development of functional brain networks important for executive function (EF) could serve as potential mediators of this association. We analyzed data of 475 adolescents, a subsample of the multisite longitudinal NCANDA (National Consortium on Alcohol and Neurodevelopment in Adolescence) cohort with completed measures of childhood trauma, resting-state functional brain connectivity data, and symptoms of internalizing and externalizing psychopathology at baseline and follow-up years 1-4. Using parallel process latent growth models, we found that childhood adversity was associated with increased risk for externalizing/internalizing behaviors. We specifically investigated whether functional connectivity of the dorsal anterior cingulate cortex (dACC) to brain regions within the cingulo-opercular (CO) network, a well-known EF network that underlies control of attention and self-regulation, mediates the association between adversity and symptoms of psychopathology. We found that childhood adversity, specifically child neglect was negatively associated with functional connectivity of the dACC within the CO network, and that this connectivity mediated the association between neglect and externalizing behaviors. Our study advances a mechanistic understanding of how childhood adversity may impact the development of psychopathology, highlighting the relevance of dACC functional networks particularly for externalizing psychopathology.
(Copyright © 2021 The Author(s). Published by Elsevier Ltd.. All rights reserved.)
معلومات مُعتمدة: U24 AA021697 United States AA NIAAA NIH HHS; U01 AA021696 United States AA NIAAA NIH HHS; U01 AA021691 United States AA NIAAA NIH HHS; U01 AA021681 United States AA NIAAA NIH HHS; U01 AA021695 United States AA NIAAA NIH HHS; U01 AA021692 United States AA NIAAA NIH HHS; U01 AA021690 United States AA NIAAA NIH HHS; U24 AA021695 United States AA NIAAA NIH HHS; U01 AA021697 United States AA NIAAA NIH HHS
فهرسة مساهمة: Keywords: Childhood adversity; Developmental psychopathology; Dorsal anterior cingulate cortex; Externalizing; Functional brain connectivity
تواريخ الأحداث: Date Created: 20210520 Date Completed: 20211015 Latest Revision: 20211015
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8142040
DOI: 10.1016/j.dcn.2021.100962
PMID: 34015723
قاعدة البيانات: MEDLINE
الوصف
تدمد:1878-9307
DOI:10.1016/j.dcn.2021.100962