دورية أكاديمية
أعرض في EDS

Esmolol during cardiopulmonary resuscitation reduces neurological injury in a porcine model of cardiac arrest.

التفاصيل البيبلوغرافية
العنوان: Esmolol during cardiopulmonary resuscitation reduces neurological injury in a porcine model of cardiac arrest.
المؤلفون: Ruggeri L; Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Nespoli F; Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Ristagno G; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy. gristag@gmail.com.; Department of Anesthesiology, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy. gristag@gmail.com., Fumagalli F; Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Boccardo A; Dipartimento Di Medicina Veterinaria, University of Milan, Lodi, Italy., Olivari D; Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Affatato R; Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Novelli D; Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., De Giorgio D; Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Romanelli P; Dipartimento Di Medicina Veterinaria, University of Milan, Lodi, Italy.; Mouse and Animal Pathology Lab (MAPLab), Fondazione UniMi, Milan, Italy., Minoli L; Dipartimento Di Medicina Veterinaria, University of Milan, Lodi, Italy.; Mouse and Animal Pathology Lab (MAPLab), Fondazione UniMi, Milan, Italy., Cucino A; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.; Department of Anesthesiology, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy., Babini G; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.; Department of Anesthesiology, Intensive Care and Emergency, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35, 20122, Milan, Italy., Staszewsky L; Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Zani D; Dipartimento Di Medicina Veterinaria, University of Milan, Lodi, Italy., Pravettoni D; Dipartimento Di Medicina Veterinaria, University of Milan, Lodi, Italy., Belloli A; Dipartimento Di Medicina Veterinaria, University of Milan, Lodi, Italy., Scanziani E; Dipartimento Di Medicina Veterinaria, University of Milan, Lodi, Italy.; Mouse and Animal Pathology Lab (MAPLab), Fondazione UniMi, Milan, Italy., Latini R; Istituto Di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy., Magliocca A; Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy.
المصدر: Scientific reports [Sci Rep] 2021 May 20; Vol. 11 (1), pp. 10635. Date of Electronic Publication: 2021 May 20.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Cardiopulmonary Resuscitation*, Heart Arrest/*drug therapy , Neurons/*pathology , Propanolamines/*therapeutic use, Animals ; Blood Gas Analysis ; Brain/pathology ; Disease Models, Animal ; Heart Arrest/blood ; Heart Arrest/complications ; Heart Arrest/physiopathology ; Hemodynamics/drug effects ; Male ; Nerve Degeneration/blood ; Nerve Degeneration/complications ; Nerve Degeneration/pathology ; Neurons/drug effects ; Perfusion ; Phosphopyruvate Hydratase/blood ; Pressure ; Propanolamines/pharmacology ; Swine
مستخلص: Primary vasopressor efficacy of epinephrine during cardiopulmonary resuscitation (CPR) is due to its α-adrenergic effects. However, epinephrine plays β1-adrenergic actions, which increasing myocardial oxygen consumption may lead to refractory ventricular fibrillation (VF) and poor outcome. Effects of a single dose of esmolol in addition to epinephrine during CPR were investigated in a porcine model of VF with an underlying acute myocardial infarction. VF was ischemically induced in 16 pigs and left untreated for 12 min. During CPR, animals were randomized to receive epinephrine (30 µg/kg) with either esmolol (0.5 mg/kg) or saline (control). Pigs were then observed up to 96 h. Coronary perfusion pressure increased during CPR in the esmolol group compared to control (47 ± 21 vs. 24 ± 10 mmHg at min 5, p < 0.05). In both groups, 7 animals were successfully resuscitated and 4 survived up to 96 h. No significant differences were observed between groups in the total number of defibrillations delivered prior to final resuscitation. Brain histology demonstrated reductions in cortical neuronal degeneration/necrosis (score 0.3 ± 0.5 vs. 1.3 ± 0.5, p < 0.05) and hippocampal microglial activation (6 ± 3 vs. 22 ± 4%, p < 0.01) in the esmolol group compared to control. Lower circulating levels of neuron specific enolase were measured in esmolol animals compared to controls (2[1-3] vs. 21[16-52] ng/mL, p < 0.01). In this preclinical model, β1-blockade during CPR did not facilitate VF termination but provided neuroprotection.
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المشرفين على المادة: 0 (Propanolamines)
EC 4.2.1.11 (Phosphopyruvate Hydratase)
MDY902UXSR (esmolol)
تواريخ الأحداث: Date Created: 20210521 Date Completed: 20211029 Latest Revision: 20211029
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8138021
DOI: 10.1038/s41598-021-90202-w
PMID: 34017043
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-90202-w