دورية أكاديمية
أعرض في EDS

Redox imbalance is related to HIV and pregnancy.

التفاصيل البيبلوغرافية
العنوان: Redox imbalance is related to HIV and pregnancy.
المؤلفون: Martinez Manfio V; Department of Tropical Diseases- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil., Tasca KI; Department of Microbiology and Immunology- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil., Garcia JL; Department of Medical Clinics- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil., de Oliveira Góis J; Department of Tropical Diseases- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil., Correa CR; Department of Medical Clinics- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil., de Souza LDR; Department of Tropical Diseases- São Paulo State University-UNESP/Botucatu-Brazil, Botucatu, São Paulo, Brazil.
المصدر: PloS one [PLoS One] 2021 May 21; Vol. 16 (5), pp. e0251619. Date of Electronic Publication: 2021 May 21 (Print Publication: 2021).
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Public Library of Science Country of Publication: United States NLM ID: 101285081 Publication Model: eCollection Cited Medium: Internet ISSN: 1932-6203 (Electronic) Linking ISSN: 19326203 NLM ISO Abbreviation: PLoS One Subsets: MEDLINE
أسماء مطبوعة: Original Publication: San Francisco, CA : Public Library of Science
مواضيع طبية MeSH: Protein Carbonylation*, Catalase/*blood , HIV Infections/*blood , Malondialdehyde/*blood , Pregnancy Complications, Infectious/*blood , Superoxide Dismutase/*blood, Adolescent ; Adult ; Biomarkers/blood ; Female ; Humans ; Oxidation-Reduction ; Pregnancy
مستخلص: Redox imbalance may compromise the homeostasis of physiological processes indispensable to gestational development in HIV-infected women. The present study aims to evaluate markers of the redox system in the development of pregnancy of these women. HIV-positive pregnant women, HIV-negative pregnant women and non-pregnant were studied. Redox markers superoxide dismutase (SOD), catalase (CAT), protein carbonylation and malondialdehyde (MDA) were assessed at first or second trimester, third trimester and postpartum from pregnant and from non-pregnant women. According to the longitudinal analysis model, CAT activity was increased in the postpartum in HIV-positive women and before delivery in HIV-negative women. Increased carbonylation was observed in the pre-delivery period of HIV-negative pregnant women and MDA concentrations were higher in HIV-positive pregnant women compared to those non-infected by HIV at all times. According to the factorial model, higher SOD and CAT activities were observed in HIV-positive women in the initial months of pregnancy and in non-pregnant women. Carbonylation at third trimester was more evident in HIV-negative pregnant women. MDA levels were higher in HIV-positive pregnant women. Increased oxidative stress may occur in HIV-infected pregnant women. Nevertheless, the HIV virus is not solely responsible for this process; instead, mechanisms inherent to the pregnancy seem to play a role in this imbalance.
Competing Interests: The authors have declared that no competing interests exist.
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المشرفين على المادة: 0 (Biomarkers)
4Y8F71G49Q (Malondialdehyde)
EC 1.11.1.6 (Catalase)
EC 1.15.1.1 (Superoxide Dismutase)
تواريخ الأحداث: Date Created: 20210521 Date Completed: 20211018 Latest Revision: 20240402
رمز التحديث: 20240402
مُعرف محوري في PubMed: PMC8139510
DOI: 10.1371/journal.pone.0251619
PMID: 34019550
قاعدة البيانات: MEDLINE
الوصف
تدمد:1932-6203
DOI:10.1371/journal.pone.0251619