دورية أكاديمية
Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents.
| العنوان: | Functional triterpenoids from medicinal fungi Ganoderma applanatum: A continuous search for antiadipogenic agents. |
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| المؤلفون: | Su HG; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, People's Republic of China; University of the Chinese Academy of Science, Beijing 100049, People's Republic of China., Wang Q; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, People's Republic of China; University of the Chinese Academy of Science, Beijing 100049, People's Republic of China., Zhou L; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, People's Republic of China., Peng XR; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, People's Republic of China. Electronic address: pengxingrong@mail.kib.ac.cn., Xiong WY; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, People's Republic of China; Key Laboratory of Medicinal Chemistry for Natural Resource, Yunnan University, Kunming, Yunnan 650500, People's Republic of China. Electronic address: xwy@ynu.edu.cn., Qiu MH; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Science, Kunming 650201, People's Republic of China. Electronic address: mhchiu@mail.kib.ac.cn. |
| المصدر: | Bioorganic chemistry [Bioorg Chem] 2021 Jul; Vol. 112, pp. 104977. Date of Electronic Publication: 2021 May 07. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 1303703 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1090-2120 (Electronic) Linking ISSN: 00452068 NLM ISO Abbreviation: Bioorg Chem Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Amsterdam : Elsevier Original Publication: New York, London, Academic Press. |
| مواضيع طبية MeSH: | Adipocytes/*drug effects , Adipogenesis/*drug effects , Anti-Obesity Agents/*pharmacology , Ganoderma/*chemistry , Triterpenes/*pharmacology, 3T3-L1 Cells ; Animals ; Anti-Obesity Agents/chemistry ; Anti-Obesity Agents/isolation & purification ; Cell Differentiation/drug effects ; Cell Survival/drug effects ; Cells, Cultured ; Dose-Response Relationship, Drug ; Lipids/analysis ; Mice ; Molecular Structure ; Structure-Activity Relationship ; Triterpenes/chemistry ; Triterpenes/isolation & purification |
| مستخلص: | Previously, we have demonstrated the antiadipogenic benefits of Ganoderma triterpenoids (GTs), which indicated GTs have potential therapeutic implications for obesity. In this study, the EtOAc extract of Ganoderma applanatum was further phytochemically investigated for searching new antiadipogenic agents, which led to the isolation of a total of 15 highly oxygenated lanostane triterpenoids, including 9 new compounds (1-9) and 6 known analogues (10-15). Structurally, ganodapplanoic acids A and B (1, 2) are two rearranged 6/6/5/6-fused lanostane-type triterpenoids with an unusual C-13/C-15 oxygen bridge moiety. In addition, the EtOAc extract (GAE) and isolates (1-4,6-15) were assayed for their antiadipogenic effects in 3T3-L1 adipocytes. The results revealed that compound 9 effectively repressed adipogenesis through down-regulating the expression of major proteins (PPARγ, CEBPβ and FAS) involving differentiation and adipogenesis in 3T3-L1 adipocytes. Thus, the present study further demonstrated the antiadipogenic potential of GTs and provided a possible perspective for obesity treatment. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: 3T3-L1 adipocytes; Antiadipogenic effects; Ganoderma applanatum; Lanostane triterpenoids |
| المشرفين على المادة: | 0 (Anti-Obesity Agents) 0 (Lipids) 0 (Triterpenes) |
| تواريخ الأحداث: | Date Created: 20210521 Date Completed: 20211022 Latest Revision: 20211022 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1016/j.bioorg.2021.104977 |
| PMID: | 34020237 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1090-2120 |
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| DOI: | 10.1016/j.bioorg.2021.104977 |