دورية أكاديمية
Immunometabolism of Tissue-Resident Macrophages - An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies.
| العنوان: | Immunometabolism of Tissue-Resident Macrophages - An Appraisal of the Current Knowledge and Cutting-Edge Methods and Technologies. |
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| المؤلفون: | Zago G; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States., Saavedra PHV; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States., Keshari KR; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY, United States.; Molecular Pharmacology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States., Perry JSA; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, United States.; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, United States.; Department of Immunology and Microbial Pathogenesis, Weill Cornell Medical College, New York, NY, United States. |
| المصدر: | Frontiers in immunology [Front Immunol] 2021 May 07; Vol. 12, pp. 665782. Date of Electronic Publication: 2021 May 07 (Print Publication: 2021). |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Frontiers Research Foundation] Country of Publication: Switzerland NLM ID: 101560960 Publication Model: eCollection Cited Medium: Internet ISSN: 1664-3224 (Electronic) Linking ISSN: 16643224 NLM ISO Abbreviation: Front Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Lausanne : Frontiers Research Foundation] |
| مواضيع طبية MeSH: | Host-Pathogen Interactions/*immunology , Macrophages/*immunology , Macrophages/*metabolism , Metabolism/*immunology, Animals ; Biotechnology ; Homeostasis ; Humans ; Immunity/immunology ; Inflammation/immunology ; Inflammation/metabolism ; Molecular Imaging |
| مستخلص: | Tissue-resident macrophages exist in unique environments, or niches, that inform their identity and function. There is an emerging body of literature suggesting that the qualities of this environment, such as the types of cells and debris they eat, the intercellular interactions they form, and the length of time spent in residence, collectively what we call habitare , directly inform their metabolic state. In turn, a tissue-resident macrophage's metabolic state can inform their function, including whether they resolve inflammation and protect the host from excessive perturbations of homeostasis. In this review, we summarize recent work that seeks to understand the metabolic requirements for tissue-resident macrophage identity and maintenance, for how they respond to inflammatory challenges, and for how they perform homeostatic functions or resolve inflammatory insults. We end with a discussion of the emerging technologies that are enabling, or will enable, in situ study of tissue-resident macrophage metabolism. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2021 Zago, Saavedra, Keshari and Perry.) |
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| معلومات مُعتمدة: | P30 CA008748 United States CA NCI NIH HHS; R01 CA248364 United States CA NCI NIH HHS; R00 CA237728 United States CA NCI NIH HHS |
| فهرسة مساهمة: | Keywords: development; homeostasis; inflammation; metabolism; tissue-resident macrophages |
| تواريخ الأحداث: | Date Created: 20210524 Date Completed: 20211025 Latest Revision: 20211025 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8138590 |
| DOI: | 10.3389/fimmu.2021.665782 |
| PMID: | 34025667 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1664-3224 |
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| DOI: | 10.3389/fimmu.2021.665782 |