دورية أكاديمية
The difference in local, regional and distant breast cancer recurrence between the immediate and delayed DIEP flap procedure; a retrospective cohort study.
العنوان: | The difference in local, regional and distant breast cancer recurrence between the immediate and delayed DIEP flap procedure; a retrospective cohort study. |
---|---|
المؤلفون: | Joosen MEM; Department of General Surgery, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands. milou.joosen@mumc.nl., Schop SJ; Department of Plastic Surgery, Maastricht University Medical Center +, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., Reinhoudt LL; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., van Kuijk SMJ; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., Beugels J; Department of Plastic Surgery, Maastricht University Medical Center +, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., de Bruïne AP; Department of Pathology, VieCuri Medical Center, Tegelseweg 210, 5912 BL, Venlo, The Netherlands., Goudkade D; Department of Pathology, Zuyderland Medical Center Sittard-Geleen, Dr. H. van der Hoffplein 1, 6162 BG, Sittard-Geleen, The Netherlands., Heuts EM; Department of General Surgery, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., van der Hulst RRWJ; Department of Plastic Surgery, Maastricht University Medical Center +, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., de Grzymala AAP; Department of Plastic Surgery, Maastricht University Medical Center +, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands. andrzej.piatkowskidegrzymala@mumc.nl. |
المصدر: | Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Jul; Vol. 188 (2), pp. 389-398. Date of Electronic Publication: 2021 May 24. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE |
أسماء مطبوعة: | Publication: Dordrecht : Kluwer Academic Original Publication: The Hague ; Boston : M. Nijhoff, c1981- |
مواضيع طبية MeSH: | Breast Neoplasms*/epidemiology , Breast Neoplasms*/surgery , Mammaplasty*/adverse effects, Epigastric Arteries/surgery ; Female ; Humans ; Mastectomy ; Neoplasm Recurrence, Local/epidemiology ; Netherlands ; Retrospective Studies |
مستخلص: | Purpose: It has been hypothesized that autologous breast reconstruction can cause reactivation of dormant micro metastases by its extensive tissue trauma, influencing the risk of breast cancer recurrence. However, about the specific effect of timing on breast cancer recurrence in the deep inferior epigastric perforator (DIEP) flap reconstruction is not much known. In this study the rate of local, regional and distant recurrence between patients undergoing an immediate and delayed autologous DIEP flap breast reconstruction were evaluated. Methods: In this retrospective cohort study, breast cancer patients undergoing a DIEP flap breast reconstruction between 2010 and 2018 in three hospitals in the Netherlands were evaluated. Cox proportional hazards regression analyses were performed to assess the impact of different factors on breast cancer recurrence. The primary endpoint was local breast cancer recurrence. Secondary endpoints were regional and distant recurrence. Results: A total of 919 DIEP-flap reconstructions were done in 862 women of which 347 were immediate- and 572 were delayed DIEP flap reconstructions. After a median follow-up of 46 months and 86 months respectively (p < 0.001), local breast cancer recurrence occurred in 1.5% and in 1.7% of the patients resulting in an adjusted hazard ratio of 2.890 (p = 0.001, 95% CI 1.536, 5437). Conclusion: This study suggests an increased risk for breast cancer recurrence in women receiving a delayed DIEP flap reconstruction as compared to women receiving an immediate DIEP flap reconstruction. However, these data should be interpreted carefully as a result of selection bias. |
References: | Ann Plast Surg. 1994 Jan;32(1):32-8. (PMID: 8141534) Breast. 2018 Feb;37:72-79. (PMID: 29102781) Plast Reconstr Surg. 1998 Apr;101(4):964-8; discussion 969-70. (PMID: 9514328) Breast Cancer Res. 2008;10(5):R83. (PMID: 18844974) Br J Surg. 2018 Oct;105(11):1435-1445. (PMID: 29683203) N Engl J Med. 2002 Oct 17;347(16):1233-41. (PMID: 12393820) APMIS. 2008 Jul-Aug;116(7-8):730-41. (PMID: 18834415) Surg Clin North Am. 2007 Apr;87(2):453-67, x. (PMID: 17498537) Surgery. 2003 May;133(5):547-55. (PMID: 12773983) Am J Pathol. 1998 Sep;153(3):865-73. (PMID: 9736035) Breast Cancer Res Treat. 2018 Jun;169(2):349-357. (PMID: 29399731) Br J Plast Surg. 2005 Jun;58(4):493-7. (PMID: 15897033) J Plast Surg Hand Surg. 2019 Apr;53(2):119-124. (PMID: 30654667) Ann Oncol. 2012 Apr;23(4):866-9. (PMID: 21765042) N Engl J Med. 2008 Oct 9;359(15):1590-601. (PMID: 18843123) Breast J. 2007 Sep-Oct;13(5):470-8. (PMID: 17760668) Breast Cancer Res Treat. 2016 Jul;158(1):169-178. (PMID: 27306422) Brain Behav Immun. 2013 Mar;30 Suppl:S32-40. (PMID: 22504092) Breast Dis. 2006-2007;26:99-114. (PMID: 17473369) Ann Surg Oncol. 1998 Oct-Nov;5(7):620-6. (PMID: 9831111) Lancet Oncol. 2012 Apr;13(4):412-9. (PMID: 22373563) Br J Surg. 2018 Oct;105(11):1446-1453. (PMID: 29999520) BMC Cancer. 2018 Oct 19;18(1):994. (PMID: 30340548) Eur J Surg Oncol. 2000 Feb;26(1):17-9. (PMID: 10718173) Brain Behav Immun. 2003 Feb;17 Suppl 1:S27-36. (PMID: 12615183) Breast Cancer Res Treat. 2005 Sep;93(1):35-40. (PMID: 16184456) Cleve Clin J Med. 2008 Mar;75 Suppl 1:S30-3. (PMID: 18457195) Nat Cell Biol. 2013 Jul;15(7):807-17. (PMID: 23728425) Am J Surg. 2009 Feb;197(2):216-21. (PMID: 18614141) Br J Surg. 2011 May;98(5):659-66. (PMID: 21312190) Surgery. 2000 Mar;127(3):329-36. (PMID: 10715990) Ann Oncol. 2005 Sep;16(9):1449-57. (PMID: 15956037) Plast Reconstr Surg. 2016 Oct;138(4):772-780. (PMID: 27673514) Nat Clin Pract Oncol. 2007 Dec;4(12):699-710. (PMID: 18037874) |
فهرسة مساهمة: | Keywords: Autologous breast reconstruction; Breast cancer; Breast reconstruction; DIEP flap procedure; Oncological safety; Reconstructive surgery |
تواريخ الأحداث: | Date Created: 20210524 Date Completed: 20210708 Latest Revision: 20210721 |
رمز التحديث: | 20221213 |
مُعرف محوري في PubMed: | PMC8260410 |
DOI: | 10.1007/s10549-021-06199-3 |
PMID: | 34028673 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1573-7217 |
---|---|
DOI: | 10.1007/s10549-021-06199-3 |