دورية أكاديمية
أعرض في EDS

The difference in local, regional and distant breast cancer recurrence between the immediate and delayed DIEP flap procedure; a retrospective cohort study.

التفاصيل البيبلوغرافية
العنوان: The difference in local, regional and distant breast cancer recurrence between the immediate and delayed DIEP flap procedure; a retrospective cohort study.
المؤلفون: Joosen MEM; Department of General Surgery, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands. milou.joosen@mumc.nl., Schop SJ; Department of Plastic Surgery, Maastricht University Medical Center +, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., Reinhoudt LL; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., van Kuijk SMJ; Department of Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., Beugels J; Department of Plastic Surgery, Maastricht University Medical Center +, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., de Bruïne AP; Department of Pathology, VieCuri Medical Center, Tegelseweg 210, 5912 BL, Venlo, The Netherlands., Goudkade D; Department of Pathology, Zuyderland Medical Center Sittard-Geleen, Dr. H. van der Hoffplein 1, 6162 BG, Sittard-Geleen, The Netherlands., Heuts EM; Department of General Surgery, Maastricht University Medical Center+, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., van der Hulst RRWJ; Department of Plastic Surgery, Maastricht University Medical Center +, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands., de Grzymala AAP; Department of Plastic Surgery, Maastricht University Medical Center +, P. Debyelaan 25, 6229 HX, Maastricht, The Netherlands. andrzej.piatkowskidegrzymala@mumc.nl.
المصدر: Breast cancer research and treatment [Breast Cancer Res Treat] 2021 Jul; Vol. 188 (2), pp. 389-398. Date of Electronic Publication: 2021 May 24.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Kluwer Academic Country of Publication: Netherlands NLM ID: 8111104 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-7217 (Electronic) Linking ISSN: 01676806 NLM ISO Abbreviation: Breast Cancer Res Treat Subsets: MEDLINE
أسماء مطبوعة: Publication: Dordrecht : Kluwer Academic
Original Publication: The Hague ; Boston : M. Nijhoff, c1981-
مواضيع طبية MeSH: Breast Neoplasms*/epidemiology , Breast Neoplasms*/surgery , Mammaplasty*/adverse effects, Epigastric Arteries/surgery ; Female ; Humans ; Mastectomy ; Neoplasm Recurrence, Local/epidemiology ; Netherlands ; Retrospective Studies
مستخلص: Purpose: It has been hypothesized that autologous breast reconstruction can cause reactivation of dormant micro metastases by its extensive tissue trauma, influencing the risk of breast cancer recurrence. However, about the specific effect of timing on breast cancer recurrence in the deep inferior epigastric perforator (DIEP) flap reconstruction is not much known. In this study the rate of local, regional and distant recurrence between patients undergoing an immediate and delayed autologous DIEP flap breast reconstruction were evaluated.
Methods: In this retrospective cohort study, breast cancer patients undergoing a DIEP flap breast reconstruction between 2010 and 2018 in three hospitals in the Netherlands were evaluated. Cox proportional hazards regression analyses were performed to assess the impact of different factors on breast cancer recurrence. The primary endpoint was local breast cancer recurrence. Secondary endpoints were regional and distant recurrence.
Results: A total of 919 DIEP-flap reconstructions were done in 862 women of which 347 were immediate- and 572 were delayed DIEP flap reconstructions. After a median follow-up of 46 months and 86 months respectively (p < 0.001), local breast cancer recurrence occurred in 1.5% and in 1.7% of the patients resulting in an adjusted hazard ratio of 2.890 (p = 0.001, 95% CI 1.536, 5437).
Conclusion: This study suggests an increased risk for breast cancer recurrence in women receiving a delayed DIEP flap reconstruction as compared to women receiving an immediate DIEP flap reconstruction. However, these data should be interpreted carefully as a result of selection bias.
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فهرسة مساهمة: Keywords: Autologous breast reconstruction; Breast cancer; Breast reconstruction; DIEP flap procedure; Oncological safety; Reconstructive surgery
تواريخ الأحداث: Date Created: 20210524 Date Completed: 20210708 Latest Revision: 20210721
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8260410
DOI: 10.1007/s10549-021-06199-3
PMID: 34028673
قاعدة البيانات: MEDLINE
الوصف
تدمد:1573-7217
DOI:10.1007/s10549-021-06199-3