التفاصيل البيبلوغرافية
| العنوان: |
A Review of Hypertrophic Scar and Keloid Treatment and Prevention in the Pediatric Population: Where Are We Now? |
| المؤلفون: |
Menchaca AD; Center for Regenerative Medicine, Department of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA.; Department of General Surgery, Indiana University, Indianapolis, Indiana, USA., Style CC; Center for Regenerative Medicine, Department of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA., Olutoye OO; Center for Regenerative Medicine, Department of Pediatric Surgery, Nationwide Children's Hospital, The Ohio State University, Columbus, Ohio, USA.; Department of Surgery, The Ohio State University, Columbus, Ohio, USA. |
| المصدر: |
Advances in wound care [Adv Wound Care (New Rochelle)] 2022 May; Vol. 11 (5), pp. 255-279. Date of Electronic Publication: 2021 Jul 14. |
| نوع المنشور: |
Journal Article; Review |
| اللغة: |
English |
| بيانات الدورية: |
Publisher: Mary Ann Liebert, Inc Country of Publication: United States NLM ID: 101590593 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2162-1918 (Print) Linking ISSN: 21621918 NLM ISO Abbreviation: Adv Wound Care (New Rochelle) Subsets: MEDLINE |
| أسماء مطبوعة: |
Original Publication: New Rochelle, N.Y. : Mary Ann Liebert, Inc. |
| مواضيع طبية MeSH: |
Cicatrix, Hypertrophic*/prevention & control , Keloid*/pathology , Keloid*/prevention & control , Lasers, Gas*/therapeutic use, Animals ; Carbon Dioxide ; Child ; Humans ; Reproducibility of Results |
| مستخلص: |
Significance: This body of work gives a concise and comprehensive overview for the clinician and scientist on the latest treatment modalities for hypertrophic scars (HTS) and keloids in the pediatric population, as well as the most promising methods of prevention currently being investigated. This review will serve as a guide to the clinician for treatment selection and as an efficient tool for the scientist to achieve a comprehensive overview of the scientific literature to guide their future experiments aimed at pathologic scar prevention. Recent Advances: Current studies in the literature suggest carbon dioxide (CO 2 ) laser and E-light (bipolar radiofrequency, intense pulsed light, and cooling) are two of the most effective treatment modalities for HTS, while surgical excision+CO 2 laser+triamcinolone injection was one of the most successful treatments for keloids. In animal models, drug impregnated electrospun nanofiber dressings offer encouraging results for HTS prevention, while Kelulut honey showed promising results for keloid prevention. Critical Issues: Treatment outcome reproducibility is hindered by small cohorts of patients, inadequate-follow up, and variability in assessment tools. Prevention studies show multiple ways of achieving the same result, yet fall short of complete prevention. Furthermore, some studies that have purported full prevention have not been validated. Future Directions: To establish a standard of care, large clinical trials of the most successful modalities in small cohorts are needed. The key for prevention will be validation in animal models of the most successful methods, followed by translational and clinical studies. |
| فهرسة مساهمة: |
Keywords: hypertrophic scar; keloid; pediatric; prevention; treatment |
| المشرفين على المادة: |
142M471B3J (Carbon Dioxide) |
| تواريخ الأحداث: |
Date Created: 20210525 Date Completed: 20220504 Latest Revision: 20220504 |
| رمز التحديث: |
20240628 |
| DOI: |
10.1089/wound.2021.0028 |
| PMID: |
34030473 |
| قاعدة البيانات: |
MEDLINE |
