دورية أكاديمية
Investigating the expression pattern of the angiopoietin-Tie system in ALL and its correlation with baseline characteristics.
| العنوان: | Investigating the expression pattern of the angiopoietin-Tie system in ALL and its correlation with baseline characteristics. |
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| المؤلفون: | Khosravi SZ; Immunology Research Center, Tabriz, Iran.; Division of Hematology and Transfusion Medicine, Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Ramshe SM; Student Research Committee, Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Farsani MA; HSCT Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Solali S; Division of Hematology and Transfusion Medicine, Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Moonesi M; Immunology Research Center, Tabriz, Iran.; Division of Hematology and Transfusion Medicine, Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Hagh MF; Immunology Research Center, Tabriz, Iran.; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. |
| المصدر: | Blood research [Blood Res] 2021 Jun 30; Vol. 56 (2), pp. 79-85. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Nature Country of Publication: Korea (South) NLM ID: 101605247 Publication Model: Print Cited Medium: Print ISSN: 2287-979X (Print) Linking ISSN: 2287979X NLM ISO Abbreviation: Blood Res Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2024- : [Cham, Switzerland] : Springer Nature Original Publication: Seoul : Korean Society of Hematology |
| مستخلص: | Background: Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children. Several environmental and genetic factors are known to be involved in its development and progression. The angiopoietin-Tie system is one of the most critical factors in angiogenesis, and its possible role in solid tumors and leukemia has been previously investigated. In this study, we examined the expression of these genes in ALL patients (early pre-B-ALL and pre-B-ALL) and compared them with normal samples. Methods: Bone marrow samples were collected from 40 patients (aged 0‒19 yr) newly diagnosed with early pre-B-ALL or pre-B-ALL using molecular and flow cytometric tests and from 15 control individuals. For molecular tests, RNA extraction and cDNA synthesis were performed, and Ang1, Ang2, Ang4, Tie1 , and Tie2 gene expression was examined by real-time polymerase chain reaction. Results: Ang2, Tie1 , and Tie2 gene expression were significantly increased in patients with ALL, whereas Ang1 gene expression was decreased. The Ang4 gene did not show significant expression changes between the two groups. Conclusion: Changes in the expression of the Ang-Tie system indicate a possible role of angiogenesis in ALL prognosis. Moreover, such changes can be considered as potential diagnostic biomarkers or therapeutic targets. |
| References: | Cancer Cell. 2011 Apr 12;19(4):512-26. (PMID: 21481792) Science. 1997 Jul 4;277(5322):55-60. (PMID: 9204896) Pediatr Blood Cancer. 2007 Apr;48(4):387-92. (PMID: 16685739) J Signal Transduct. 2014;2014:173026. (PMID: 25371820) Hematology. 2016 Jul;21(6):325-31. (PMID: 26901808) Leukemia. 2007 Sep;21(9):1901-6. (PMID: 17597808) Cancer. 2002 Mar 1;94(5):1517-21. (PMID: 11920509) Blood Cancer J. 2017 Jun 30;7(6):e577. (PMID: 28665419) Microvasc Res. 2002 Jul;64(1):135-47. (PMID: 12074640) Br J Cancer. 2007 Oct 8;97(7):877-82. (PMID: 17848952) Leukemia. 2008 Feb;22(2):287-93. (PMID: 17943167) CA Cancer J Clin. 2020 Jan;70(1):7-30. (PMID: 31912902) Int J Radiat Biol. 2021;97(2):179-193. (PMID: 32970517) J Clin Oncol. 2005 Feb 20;23(6):1109-17. (PMID: 15718307) Intractable Rare Dis Res. 2016 Feb;5(1):6-16. (PMID: 26989643) Clin Sci (Lond). 2017 Jan 1;131(1):87-103. (PMID: 27941161) N Engl J Med. 2015 Oct 15;373(16):1541-52. (PMID: 26465987) Indian J Hematol Blood Transfus. 2009 Mar;25(1):17-22. (PMID: 23100966) Haematologica. 2006 Sep;91(9):1203-11. (PMID: 16956819) Indian J Hematol Blood Transfus. 2016 Jun;32(2):162-7. (PMID: 27065577) Leuk Res. 2001 Apr;25(4):279-85. (PMID: 11248324) Oncogene. 2000 Sep 14;19(39):4549-52. (PMID: 11002428) Mol Cell. 2010 Mar 12;37(5):643-55. (PMID: 20227369) FASEB J. 2004 Aug;18(11):1200-8. (PMID: 15284220) Ann Hematol. 2010 May;89(5):459-67. (PMID: 20054548) Leuk Res. 2002 Feb;26(2):163-8. (PMID: 11755466) Nat Rev Cancer. 2010 Aug;10(8):575-85. (PMID: 20651738) APMIS. 2019 Dec;127(12):737-745. (PMID: 31273832) Br J Cancer. 2011 Sep 27;105(7):975-82. (PMID: 21878936) Leuk Lymphoma. 2001 Jul;42(3):511-6. (PMID: 11699417) Leuk Lymphoma. 2003 Feb;44(2):213-22. (PMID: 12688336) Pathol Oncol Res. 2020 Jan;26(1):461-466. (PMID: 30443842) Int J Oncol. 2018 Mar;52(3):656-678. (PMID: 29286103) Cell. 1996 Dec 27;87(7):1161-9. (PMID: 8980223) Leuk Res. 2008 Jun;32(6):904-12. (PMID: 17904634) Asian Pac J Cancer Prev. 2018 May 26;20(3):705-710. (PMID: 30909668) |
| فهرسة مساهمة: | Keywords: Acute lymphoblastic leukemia; Angiopoietin; Leukemia; Tie receptor |
| تواريخ الأحداث: | Date Created: 20210525 Latest Revision: 20220424 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8246033 |
| DOI: | 10.5045/br.2021.2021024 |
| PMID: | 34031276 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2287-979X |
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| DOI: | 10.5045/br.2021.2021024 |