دورية أكاديمية
Investigating the expression pattern of the angiopoietin-Tie system in ALL and its correlation with baseline characteristics.
العنوان: | Investigating the expression pattern of the angiopoietin-Tie system in ALL and its correlation with baseline characteristics. |
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المؤلفون: | Khosravi SZ; Immunology Research Center, Tabriz, Iran.; Division of Hematology and Transfusion Medicine, Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Ramshe SM; Student Research Committee, Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Farsani MA; HSCT Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Solali S; Division of Hematology and Transfusion Medicine, Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Moonesi M; Immunology Research Center, Tabriz, Iran.; Division of Hematology and Transfusion Medicine, Department of Immunology, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran., Hagh MF; Immunology Research Center, Tabriz, Iran.; Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. |
المصدر: | Blood research [Blood Res] 2021 Jun 30; Vol. 56 (2), pp. 79-85. |
نوع المنشور: | Journal Article |
اللغة: | English |
بيانات الدورية: | Publisher: Springer Nature Country of Publication: Korea (South) NLM ID: 101605247 Publication Model: Print Cited Medium: Print ISSN: 2287-979X (Print) Linking ISSN: 2287979X NLM ISO Abbreviation: Blood Res Subsets: PubMed not MEDLINE |
أسماء مطبوعة: | Publication: 2024- : [Cham, Switzerland] : Springer Nature Original Publication: Seoul : Korean Society of Hematology |
مستخلص: | Background: Acute lymphoblastic leukemia (ALL) is the most common type of leukemia in children. Several environmental and genetic factors are known to be involved in its development and progression. The angiopoietin-Tie system is one of the most critical factors in angiogenesis, and its possible role in solid tumors and leukemia has been previously investigated. In this study, we examined the expression of these genes in ALL patients (early pre-B-ALL and pre-B-ALL) and compared them with normal samples. Methods: Bone marrow samples were collected from 40 patients (aged 0‒19 yr) newly diagnosed with early pre-B-ALL or pre-B-ALL using molecular and flow cytometric tests and from 15 control individuals. For molecular tests, RNA extraction and cDNA synthesis were performed, and Ang1, Ang2, Ang4, Tie1 , and Tie2 gene expression was examined by real-time polymerase chain reaction. Results: Ang2, Tie1 , and Tie2 gene expression were significantly increased in patients with ALL, whereas Ang1 gene expression was decreased. The Ang4 gene did not show significant expression changes between the two groups. Conclusion: Changes in the expression of the Ang-Tie system indicate a possible role of angiogenesis in ALL prognosis. Moreover, such changes can be considered as potential diagnostic biomarkers or therapeutic targets. |
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فهرسة مساهمة: | Keywords: Acute lymphoblastic leukemia; Angiopoietin; Leukemia; Tie receptor |
تواريخ الأحداث: | Date Created: 20210525 Latest Revision: 20220424 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC8246033 |
DOI: | 10.5045/br.2021.2021024 |
PMID: | 34031276 |
قاعدة البيانات: | MEDLINE |
تدمد: | 2287-979X |
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DOI: | 10.5045/br.2021.2021024 |