دورية أكاديمية
Nanoemulgel for Improved Topical Delivery of Desonide: Formulation Design and Characterization.
| العنوان: | Nanoemulgel for Improved Topical Delivery of Desonide: Formulation Design and Characterization. |
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| المؤلفون: | Ma Q; Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, 510006, China., Zhang J; Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, 510006, China., Lu B; Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, 510006, China., Lin H; Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, 510006, China. huaqing_@163.net., Sarkar R; Bright Future Pharmaceutical Lab. Ltd, Hong Kong, 999077, China., Wu T; Bright Future Pharmaceutical Lab. Ltd, Hong Kong, 999077, China., Li X; Guangdong Provincial Key Laboratory of Advanced Drug Delivery Systems, Guangdong Pharmaceutical University, Guangzhou, 510006, China. |
| المصدر: | AAPS PharmSciTech [AAPS PharmSciTech] 2021 May 24; Vol. 22 (5), pp. 163. Date of Electronic Publication: 2021 May 24. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: United States NLM ID: 100960111 Publication Model: Electronic Cited Medium: Internet ISSN: 1530-9932 (Electronic) Linking ISSN: 15309932 NLM ISO Abbreviation: AAPS PharmSciTech Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: New York : Springer Original Publication: Arlington, VA : American Association of Pharmaceutical Scientists, c2000- |
| مواضيع طبية MeSH: | Drug Delivery Systems*, Desonide/*administration & dosage , Emulsions/*chemistry , Nanogels/*administration & dosage, Administration, Topical ; Animals ; Colloids/metabolism ; Desonide/chemistry ; Excipients/metabolism ; Microscopy, Confocal ; Nanogels/chemistry ; Particle Size ; Rats ; Skin/metabolism ; Skin Absorption |
| مستخلص: | This research aimed to develop a novel drug delivery system to improve treatment of skin disorders. The system is comprised of a Carbopol 980-based nanoemulgel (NE-gel) containing a desonide (DES; 0.05%, w/w) nanoemulsion (NE), which has a small particle size, high encapsulation efficiency, good thermodynamic stability, good permeation ability, and high skin retention. DES-loaded NE (DES-NE) was prepared by high-pressure homogenization. The developed formulation was characterized by differential scanning calorimetry (DSC), X-ray diffraction, drug release, skin permeation, and drug retention. DES in vitro release and skin permeation studies with different formulations of artificial membrane and rat abdominal skin were performed with the Franz diffusion cell system. Confocal laser scanning microscopy (CLSM) was used to detect the localization and permeation pathways of drugs in the skin. Compared with commercially available gel (CA-gel) and NE, the NE-gel release process conformed to the Higuchi release model (R 2 = 0.9813). NE-gel prolonged the drug release time and allowed for reduced administration dose and frequency. The unit cumulative permeation of NE and NE-gel through the skin for 12 h was 63.13 ± 2.78 and 42.53 ± 2.06 μg/cm 2 , respectively, values significantly higher (p < 0.01) than that of the CA-gel (30.65 ± 1.25 μg/cm 2 ) and CA-cream (15.21 ± 0.97 μg/cm 2 ). The DES-NE and DES NE-gel skin drug retention was significantly higher than commercially available formulations (p < 0.01). Hence, the prepared NE-gel is a potential vehicle for improved topical DES delivery for better treatment of skin disorders. |
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| فهرسة مساهمة: | Keywords: dermatitis; desonide; nanoemulgel; nanoemulsion; topical drug delivery |
| المشرفين على المادة: | 0 (Colloids) 0 (Emulsions) 0 (Excipients) 0 (Nanogels) J280872D1O (Desonide) |
| تواريخ الأحداث: | Date Created: 20210525 Date Completed: 20210621 Latest Revision: 20210727 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1208/s12249-021-02035-5 |
| PMID: | 34031790 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1530-9932 |
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| DOI: | 10.1208/s12249-021-02035-5 |