دورية أكاديمية
أعرض في EDS

Placental Vascular Abnormalities in Association With Prenatal and Long-Term Health Characteristics Among HIV-Exposed Uninfected Adolescents and Young Adults.

التفاصيل البيبلوغرافية
العنوان: Placental Vascular Abnormalities in Association With Prenatal and Long-Term Health Characteristics Among HIV-Exposed Uninfected Adolescents and Young Adults.
المؤلفون: Fourman LT; Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Mueller SB; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and., Boutin A; Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Zheng I; Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Pan CS; Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Gerard ME; Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Stanley TL; Metabolism Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA.; Pediatric Endocrinology, Massachusetts General Hospital, Harvard Medical School, Boston, MA., Roberts DJ; Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; and.
المصدر: Journal of acquired immune deficiency syndromes (1999) [J Acquir Immune Defic Syndr] 2021 Sep 01; Vol. 88 (1), pp. 103-109.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Lippincott Williams & Wilkins, Inc Country of Publication: United States NLM ID: 100892005 Publication Model: Print Cited Medium: Internet ISSN: 1944-7884 (Electronic) Linking ISSN: 15254135 NLM ISO Abbreviation: J Acquir Immune Defic Syndr Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Hagerstown, MD : Lippincott Williams & Wilkins, Inc., c1999-
مواضيع طبية MeSH: HIV Infections/*complications , Placenta/*blood supply , Pregnancy Complications, Infectious/*virology, Adolescent ; Cohort Studies ; Female ; Humans ; Placenta/pathology ; Pregnancy ; Pulmonary Disease, Chronic Obstructive ; Young Adult
مستخلص: Background: HIV-exposed uninfected (HEU) individuals are predisposed to adverse health outcomes, which in part may stem from the influence of an altered intrauterine milieu on fetal programming. The placenta serves as a readout for the effects of the maternal environment on the developing fetus and may itself contribute to the pathogenesis of disease.
Setting: US academic health system.
Methods: We leveraged a previously established registry-based cohort of HEU adolescents and young adults to identify 26 subjects for whom placental histopathology was available. We further obtained placental tissue from 29 HIV-unexposed pregnancies for comparison. We examined differences in placental histopathology between the groups and related villous vascularity in the HEU group to prenatal maternal characteristics and long-term health outcomes.
Results: Placentas from HEU pregnancies demonstrated a higher blood vessel count per villus as compared with controls (5.9 ± 1.0 vs. 5.4 ± 0.8; P = 0.05), which was independent of maternal prenatal age, race, body mass index, smoking status, hemoglobin, and gestational age. Furthermore, within the HEU group, lower CD4+ T-cell count during pregnancy was associated with greater placental vascularity (r = -0.44; P = 0.03). No significant relationships were observed between placental blood vessel count per villus and body mass index z-score or reactive airway disease among HEU individuals later in life.
Conclusions: Placentas from HEU pregnancies demonstrated increased villous vascularity compared with HIV-unexposed controls in proportion to the severity of maternal immune dysfunction. Further studies are needed to examine intrauterine exposure to hypoxia as a potential mechanism of fetal programming in HIV.
Competing Interests: The remaining authors have no funding or conflicts of interest to disclose.
(Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.)
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معلومات مُعتمدة: K23 HD100266 United States HD NICHD NIH HHS; P30 DK040561 United States DK NIDDK NIH HHS
تواريخ الأحداث: Date Created: 20210525 Date Completed: 20211230 Latest Revision: 20230927
رمز التحديث: 20230927
مُعرف محوري في PubMed: PMC8373807
DOI: 10.1097/QAI.0000000000002734
PMID: 34034303
قاعدة البيانات: MEDLINE
الوصف
تدمد:1944-7884
DOI:10.1097/QAI.0000000000002734