دورية أكاديمية
Broad Concordance in the Spatial Distribution of Adaptive and Neutral Genetic Variation across an Elevational Gradient in Deer Mice.
العنوان: | Broad Concordance in the Spatial Distribution of Adaptive and Neutral Genetic Variation across an Elevational Gradient in Deer Mice. |
---|---|
المؤلفون: | Schweizer RM; Division of Biological Sciences, University of Montana, Missoula, MT, USA., Jones MR; Division of Biological Sciences, University of Montana, Missoula, MT, USA.; Southwest Biological Science Center, U.S. Geological Survey, Flagstaff, AZ, USA., Bradburd GS; Ecology, Evolution, and Behavior Program, Department of Integrative Biology, Michigan State University, East Lansing, MI, USA., Storz JF; School of Biological Sciences, University of Nebraska, Lincoln, NE, USA., Senner NR; Division of Biological Sciences, University of Montana, Missoula, MT, USA.; Department of Biological Sciences, University of South Carolina, Columbia, SC, USA., Wolf C; Division of Biological Sciences, University of Montana, Missoula, MT, USA., Cheviron ZA; Division of Biological Sciences, University of Montana, Missoula, MT, USA. |
المصدر: | Molecular biology and evolution [Mol Biol Evol] 2021 Sep 27; Vol. 38 (10), pp. 4286-4300. |
نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S. |
اللغة: | English |
بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE |
أسماء مطبوعة: | Publication: 2003- : New York, NY : Oxford University Press Original Publication: [Chicago, Ill.] : University of Chicago Press, [c1983- |
مواضيع طبية MeSH: | Gene Flow* , Peromyscus*/genetics, Adaptation, Physiological/genetics ; Altitude ; Animals ; Genetic Variation ; Genetics, Population |
مستخلص: | When species are continuously distributed across environmental gradients, the relative strength of selection and gene flow shape spatial patterns of genetic variation, potentially leading to variable levels of differentiation across loci. Determining whether adaptive genetic variation tends to be structured differently than neutral variation along environmental gradients is an open and important question in evolutionary genetics. We performed exome-wide population genomic analysis on deer mice sampled along an elevational gradient of nearly 4,000 m of vertical relief. Using a combination of selection scans, genotype-environment associations, and geographic cline analyses, we found that a large proportion of the exome has experienced a history of altitude-related selection. Elevational clines for nearly 30% of these putatively adaptive loci were shifted significantly up- or downslope of clines for loci that did not bear similar signatures of selection. Many of these selection targets can be plausibly linked to known phenotypic differences between highland and lowland deer mice, although the vast majority of these candidates have not been reported in other studies of highland taxa. Together, these results suggest new hypotheses about the genetic basis of physiological adaptation to high altitude, and the spatial distribution of adaptive genetic variation along environmental gradients. (© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.) |
References: | Acta Physiol (Oxf). 2018 May;223(1):e13030. (PMID: 29316265) Mol Biol Evol. 2019 Nov 1;36(11):2591-2603. (PMID: 31273382) Annu Rev Ecol Evol Syst. 2019 Nov;50:503-526. (PMID: 33033467) Mol Ecol. 2017 Jan;26(1):107-122. (PMID: 27065228) Nat Genet. 2008 May;40(5):646-9. (PMID: 18425127) Evolution. 2018 Dec;72(12):2712-2727. (PMID: 30318588) Am J Hum Genet. 2007 Sep;81(3):559-75. (PMID: 17701901) Science. 1987 May 15;236(4803):787-92. (PMID: 3576198) Genet Epidemiol. 2013 Feb;37(2):136-41. (PMID: 22996348) Evol Lett. 2020 Jun 09;4(4):317-332. (PMID: 32774881) Annu Rev Anim Biosci. 2021 Feb 16;9:149-171. (PMID: 33228375) Science. 2010 Jul 2;329(5987):75-8. (PMID: 20595611) J Exp Biol. 2017 Oct 15;220(Pt 20):3616-3620. (PMID: 28839010) Pharmacol Rev. 2013 Dec 11;66(1):102-92. (PMID: 24335194) BMC Biol. 2021 Jun 22;19(1):128. (PMID: 34158035) Nucleic Acids Res. 2011 Jul;39(Web Server issue):W307-15. (PMID: 21646343) BMC Genomics. 2016 Feb 18;17:122. (PMID: 26892324) Genetics. 2012 Jan;190(1):203-16. (PMID: 22042573) Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14450-5. (PMID: 19667207) Hypertension. 1994 Jul;24(1):63-9. (PMID: 8021009) PLoS Genet. 2018 Sep 6;14(9):e1007650. (PMID: 30188897) Bioinformatics. 2010 Mar 1;26(5):589-95. (PMID: 20080505) Evolution. 2014 Jan;68(1):48-62. (PMID: 24102503) Genome Res. 2008 Aug;18(8):1354-61. (PMID: 18493019) Am J Physiol Regul Integr Comp Physiol. 2019 Sep 1;317(3):R407-R417. (PMID: 31242021) Mol Ecol. 2016 Jun;25(12):2870-86. (PMID: 27126783) Comp Biochem Physiol B Biochem Mol Biol. 2018 Oct;224:98-104. (PMID: 29175484) Nucleic Acids Res. 2007 Jul;35(Web Server issue):W193-200. (PMID: 17478515) J Exp Biol. 2013 Apr 1;216(Pt 7):1160-6. (PMID: 23197099) Philos Trans R Soc Lond B Biol Sci. 2019 Jul 22;374(1777):20180235. (PMID: 31154977) PLoS Genet. 2014 Jul 31;10(7):e1004466. (PMID: 25078401) Science. 2010 Jul 2;329(5987):72-5. (PMID: 20466884) Mol Ecol. 2018 May;27(9):2215-2233. (PMID: 29633402) Curr Zool. 2018 Apr;64(2):193-196. (PMID: 30402059) PLoS Genet. 2014 Aug 07;10(8):e1004412. (PMID: 25102153) Genetics. 2018 Sep;210(1):33-52. (PMID: 30026187) N Am J Med Sci (Boston). 2011 Oct 1;4(4):183-190. (PMID: 22389749) Front Genet. 2018 Mar 13;9:68. (PMID: 29593776) Proc Natl Acad Sci U S A. 2012 May 29;109(22):8635-40. (PMID: 22586089) J Biol Chem. 1995 Sep 22;270(38):22434-9. (PMID: 7673230) Mol Ecol. 2016 Jan;25(1):357-79. (PMID: 26562361) Mol Ecol Resour. 2014 May;14(3):652-63. (PMID: 24373504) J Exp Biol. 2010 Aug 1;213(Pt 15):2565-74. (PMID: 20639417) J Mammal. 2019 May 23;100(3):910-922. (PMID: 31138949) Evolution. 2011 Jul;65(7):1897-911. (PMID: 21729046) Genetics. 1975 Jul;(3):595-615. (PMID: 1232026) Front Mol Biosci. 2015 Oct 28;2:60. (PMID: 26579528) Nucleic Acids Res. 2020 Jan 8;48(D1):D498-D503. (PMID: 31691815) J Biol Chem. 2021 Jan-Jun;296:100461. (PMID: 33639161) Science. 2018 Jun 22;360(6395):1355-1358. (PMID: 29930138) Science. 1992 Apr 24;256(5056):532-5. (PMID: 1373909) Bioinformatics. 2011 Aug 1;27(15):2156-8. (PMID: 21653522) J Exp Biol. 2020 Mar 11;223(Pt 5):. (PMID: 32054682) Am J Physiol Regul Integr Comp Physiol. 2018 Nov 1;315(5):R1027-R1037. (PMID: 30183337) Mol Biol Evol. 2014 May;31(5):1200-5. (PMID: 24520091) Evolution. 1999 Aug;53(4):1280-1287. (PMID: 28565539) Nat Genet. 1997 Nov;17(3):318-23. (PMID: 9354797) Monogr Popul Biol. 1977;10:1-246. (PMID: 409931) PLoS Genet. 2019 Nov 7;15(11):e1008420. (PMID: 31697676) Acta Physiol (Oxf). 2017 Dec;221(4):266-282. (PMID: 28640969) J Comp Physiol B. 2021 Mar;191(2):385-396. (PMID: 33533958) Proc Biol Sci. 2020 May 27;287(1927):20192750. (PMID: 32429808) Mol Biol Evol. 2020 Aug 1;37(8):2309-2321. (PMID: 32243546) Nucleic Acids Res. 2016 Jul 8;44(W1):W83-9. (PMID: 27098042) Mol Biol Evol. 2015 Aug;32(8):1962-76. (PMID: 25851956) Evolution. 1983 May;37(3):454-471. (PMID: 28563316) J Physiol. 2017 Jul 15;595(14):4785-4801. (PMID: 28418073) Am J Physiol Regul Integr Comp Physiol. 2015 May 1;308(9):R779-91. (PMID: 25695288) Nucleic Acids Res. 2000 Jan 1;28(1):27-30. (PMID: 10592173) Bioinformatics. 2010 Aug 15;26(16):2064-5. (PMID: 20591904) Bioinformatics. 2009 Aug 15;25(16):2078-9. (PMID: 19505943) Genetics. 2008 Sep;180(1):367-79. (PMID: 18716337) Am J Physiol Regul Integr Comp Physiol. 2017 Mar 1;312(3):R400-R411. (PMID: 28077391) J Neurochem. 2009 Jul;110(2):622-30. (PMID: 19457096) Mol Biol Evol. 2021 Jun 25;38(7):2677-2691. (PMID: 33751123) Mol Biol Evol. 2015 Apr;32(4):978-97. (PMID: 25556236) Sci Rep. 2015 Sep 25;5:14256. (PMID: 26404527) J Physiol. 2020 Dec;598(23):5411-5426. (PMID: 32886797) Proc Natl Acad Sci U S A. 2015 May 19;112(20):6401-6. (PMID: 25941385) |
معلومات مُعتمدة: | R01 HL087216 United States HL NHLBI NIH HHS; R35 GM137919 United States GM NIGMS NIH HHS; S10 RR027303 United States RR NCRR NIH HHS; S10 RR029668 United States RR NCRR NIH HHS |
فهرسة مساهمة: | Keywords: clinal selection; gene–environment association; high-altitude adaptation; local adaptation; population structure |
تواريخ الأحداث: | Date Created: 20210526 Date Completed: 20220325 Latest Revision: 20230921 |
رمز التحديث: | 20230921 |
مُعرف محوري في PubMed: | PMC8476156 |
DOI: | 10.1093/molbev/msab161 |
PMID: | 34037784 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1537-1719 |
---|---|
DOI: | 10.1093/molbev/msab161 |