دورية أكاديمية
أعرض في EDS

Broad Concordance in the Spatial Distribution of Adaptive and Neutral Genetic Variation across an Elevational Gradient in Deer Mice.

التفاصيل البيبلوغرافية
العنوان: Broad Concordance in the Spatial Distribution of Adaptive and Neutral Genetic Variation across an Elevational Gradient in Deer Mice.
المؤلفون: Schweizer RM; Division of Biological Sciences, University of Montana, Missoula, MT, USA., Jones MR; Division of Biological Sciences, University of Montana, Missoula, MT, USA.; Southwest Biological Science Center, U.S. Geological Survey, Flagstaff, AZ, USA., Bradburd GS; Ecology, Evolution, and Behavior Program, Department of Integrative Biology, Michigan State University, East Lansing, MI, USA., Storz JF; School of Biological Sciences, University of Nebraska, Lincoln, NE, USA., Senner NR; Division of Biological Sciences, University of Montana, Missoula, MT, USA.; Department of Biological Sciences, University of South Carolina, Columbia, SC, USA., Wolf C; Division of Biological Sciences, University of Montana, Missoula, MT, USA., Cheviron ZA; Division of Biological Sciences, University of Montana, Missoula, MT, USA.
المصدر: Molecular biology and evolution [Mol Biol Evol] 2021 Sep 27; Vol. 38 (10), pp. 4286-4300.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: United States NLM ID: 8501455 Publication Model: Print Cited Medium: Internet ISSN: 1537-1719 (Electronic) Linking ISSN: 07374038 NLM ISO Abbreviation: Mol Biol Evol Subsets: MEDLINE
أسماء مطبوعة: Publication: 2003- : New York, NY : Oxford University Press
Original Publication: [Chicago, Ill.] : University of Chicago Press, [c1983-
مواضيع طبية MeSH: Gene Flow* , Peromyscus*/genetics, Adaptation, Physiological/genetics ; Altitude ; Animals ; Genetic Variation ; Genetics, Population
مستخلص: When species are continuously distributed across environmental gradients, the relative strength of selection and gene flow shape spatial patterns of genetic variation, potentially leading to variable levels of differentiation across loci. Determining whether adaptive genetic variation tends to be structured differently than neutral variation along environmental gradients is an open and important question in evolutionary genetics. We performed exome-wide population genomic analysis on deer mice sampled along an elevational gradient of nearly 4,000 m of vertical relief. Using a combination of selection scans, genotype-environment associations, and geographic cline analyses, we found that a large proportion of the exome has experienced a history of altitude-related selection. Elevational clines for nearly 30% of these putatively adaptive loci were shifted significantly up- or downslope of clines for loci that did not bear similar signatures of selection. Many of these selection targets can be plausibly linked to known phenotypic differences between highland and lowland deer mice, although the vast majority of these candidates have not been reported in other studies of highland taxa. Together, these results suggest new hypotheses about the genetic basis of physiological adaptation to high altitude, and the spatial distribution of adaptive genetic variation along environmental gradients.
(© The Author(s) 2021. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.)
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معلومات مُعتمدة: R01 HL087216 United States HL NHLBI NIH HHS; R35 GM137919 United States GM NIGMS NIH HHS; S10 RR027303 United States RR NCRR NIH HHS; S10 RR029668 United States RR NCRR NIH HHS
فهرسة مساهمة: Keywords: clinal selection; gene–environment association; high-altitude adaptation; local adaptation; population structure
تواريخ الأحداث: Date Created: 20210526 Date Completed: 20220325 Latest Revision: 20230921
رمز التحديث: 20230921
مُعرف محوري في PubMed: PMC8476156
DOI: 10.1093/molbev/msab161
PMID: 34037784
قاعدة البيانات: MEDLINE
الوصف
تدمد:1537-1719
DOI:10.1093/molbev/msab161