دورية أكاديمية
أعرض في EDS

Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa.

التفاصيل البيبلوغرافية
العنوان: Distinctive genetic structure and selection patterns in Plasmodium vivax from South Asia and East Africa.
المؤلفون: Benavente ED; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Manko E; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Phelan J; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Campos M; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Nolder D; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.; Public Health England Malaria Reference Laboratory, London School of Hygiene & Tropical Medicine, London, UK., Fernandez D; Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Antioquia, Colombia., Velez-Tobon G; Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Antioquia, Colombia., Castaño AT; Grupo Malaria, Facultad de Medicina, Universidad de Antioquia, Antioquia, Colombia., Dombrowski JG; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Marinho CRF; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Aguiar ACC; Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, Brazil., Pereira DB; Research Center for Tropical Medicine of Rondonia, Porto Velho, Brazil., Sriprawat K; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Tak, Thailand., Nosten F; Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Tak, Thailand.; Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine Research Building, University of Oxford Old Road Campus, Oxford, UK., Moon R; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK., Sutherland CJ; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK.; Public Health England Malaria Reference Laboratory, London School of Hygiene & Tropical Medicine, London, UK., Campino S; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. Susana.campino@lshtm.ac.uk., Clark TG; Faculty of Infectious & Tropical Diseases, London School of Hygiene & Tropical Medicine, London, UK. taane.clark@lshtm.ac.uk.; Faculty of Epidemiology and Population Health, London School of Hygiene & Tropical Medicine, London, UK. taane.clark@lshtm.ac.uk.
المصدر: Nature communications [Nat Commun] 2021 May 26; Vol. 12 (1), pp. 3160. Date of Electronic Publication: 2021 May 26.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101528555 Publication Model: Electronic Cited Medium: Internet ISSN: 2041-1723 (Electronic) Linking ISSN: 20411723 NLM ISO Abbreviation: Nat Commun Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : Nature Pub. Group
مواضيع طبية MeSH: Genes, Protozoan* , Selection, Genetic*, Malaria, Vivax/*parasitology , Plasmodium vivax/*genetics, Africa, Eastern ; Antimalarials/pharmacology ; Antimalarials/therapeutic use ; Asia ; Drug Resistance/genetics ; Duffy Blood-Group System ; Genetic Loci ; Humans ; Malaria, Vivax/blood ; Malaria, Vivax/drug therapy ; Phylogeny ; Phylogeography ; Plasmodium vivax/drug effects ; Plasmodium vivax/pathogenicity ; Polymorphism, Single Nucleotide ; Protozoan Proteins/genetics ; Reticulocytes/parasitology
مستخلص: Despite the high burden of Plasmodium vivax malaria in South Asian countries, the genetic diversity of circulating parasite populations is not well described. Determinants of antimalarial drug susceptibility for P. vivax in the region have not been characterised. Our genomic analysis of global P. vivax (n = 558) establishes South Asian isolates (n = 92) as a distinct subpopulation, which shares ancestry with some East African and South East Asian parasites. Signals of positive selection are linked to drug resistance-associated loci including pvkelch10, pvmrp1, pvdhfr and pvdhps, and two loci linked to P. vivax invasion of reticulocytes, pvrbp1a and pvrbp1b. Significant identity-by-descent was found in extended chromosome regions common to P. vivax from India and Ethiopia, including the pvdbp gene associated with Duffy blood group binding. Our investigation provides new understanding of global P. vivax population structure and genomic diversity, and genetic evidence of recent directional selection in this important human pathogen.
References: Genetics. 2019 Aug;212(4):1337-1351. (PMID: 31209105)
J Antimicrob Chemother. 2014 Aug;69(8):2110-7. (PMID: 24855124)
Mol Ecol Resour. 2017 Jan;17(1):78-90. (PMID: 27863062)
PLoS Biol. 2007 Jul;5(7):e171. (PMID: 17579516)
Antimicrob Agents Chemother. 2009 Jun;53(6):2553-6. (PMID: 19364873)
J Natl Malar Soc. 1950 Dec;9(4):381-96. (PMID: 14804098)
Nat Genet. 2016 Aug;48(8):953-8. (PMID: 27348298)
Elife. 2019 Jun 17;8:. (PMID: 31205002)
Am J Trop Med Hyg. 2006 Oct;75(4):617-21. (PMID: 17038682)
PLoS One. 2011;6(5):e20212. (PMID: 21633513)
Infect Genet Evol. 2024 Jul 23;123:105643. (PMID: 39053565)
Lancet Infect Dis. 2014 Oct;14(10):982-91. (PMID: 25213732)
Nature. 2008 Oct 9;455(7214):757-63. (PMID: 18843361)
Lancet. 2019 Jul 27;394(10195):332-343. (PMID: 31229233)
FEBS Lett. 2016 Feb;590(4):482-92. (PMID: 26900081)
PLoS Genet. 2020 Feb 13;16(2):e1008576. (PMID: 32053607)
Am J Trop Med Hyg. 2017 Dec;97(6):1788-1796. (PMID: 29016343)
Nat Commun. 2018 Jul 3;9(1):2585. (PMID: 29968722)
Sci Rep. 2013;3:1008. (PMID: 23301149)
Nat Rev Genet. 2009 Sep;10(9):639-50. (PMID: 19687804)
PLoS One. 2019 Mar 18;14(3):e0213686. (PMID: 30883571)
Trends Parasitol. 2018 May;34(5):420-429. (PMID: 29530446)
Nat Genet. 2016 Aug;48(8):959-964. (PMID: 27348299)
PLoS One. 2017 May 11;12(5):e0177134. (PMID: 28493919)
PLoS Biol. 2006 Mar;4(3):e72. (PMID: 16494531)
Wellcome Open Res. 2016 Nov 15;1:4. (PMID: 28008421)
Bioinformatics. 2014 May 1;30(9):1292-4. (PMID: 24443379)
Nat Genet. 2011 May;43(5):491-8. (PMID: 21478889)
N Engl J Med. 2019 Jan 17;380(3):229-241. (PMID: 30650326)
Lancet. 2013 Sep 7;382(9895):900-11. (PMID: 23594387)
J Infect Dis. 2019 Oct 22;220(11):1738-1749. (PMID: 30668735)
Antimicrob Agents Chemother. 2014 Nov;58(11):6958-61. (PMID: 25155586)
Fly (Austin). 2012 Apr-Jun;6(2):80-92. (PMID: 22728672)
Genome Biol. 2017 Apr 28;18(1):78. (PMID: 28454557)
Nature. 2012 Jul 19;487(7407):375-9. (PMID: 22722859)
Genome Res. 2009 Sep;19(9):1655-64. (PMID: 19648217)
Malar J. 2020 Aug 24;19(1):299. (PMID: 32831093)
Cochrane Database Syst Rev. 2013 Oct 25;(10):CD008492. (PMID: 24163021)
Malar J. 2018 May 15;17(1):196. (PMID: 29764422)
Antimicrob Agents Chemother. 2009 Aug;53(8):3405-10. (PMID: 19433569)
mBio. 2020 Feb 25;11(1):. (PMID: 32098816)
Bioinformatics. 2004 Jan 22;20(2):289-90. (PMID: 14734327)
Bioinformatics. 2011 Apr 15;27(8):1157-8. (PMID: 21320865)
Curr Opin Microbiol. 2017 Dec;40:168-174. (PMID: 29229188)
معلومات مُعتمدة: MR/M01360X/1 United Kingdom MRC_ Medical Research Council; MR/T016124/1 United Kingdom MRC_ Medical Research Council; 106698/Z/14/Z United Kingdom WT_ Wellcome Trust; MR/N010469/1 United Kingdom MRC_ Medical Research Council; MR/R020973/1 United Kingdom MRC_ Medical Research Council; 100217/Z/12/A United Kingdom WT_ Wellcome Trust; MR/R025576/1 United Kingdom MRC_ Medical Research Council; BB/R013063/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; MR/M021157/1 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust
المشرفين على المادة: 0 (Antimalarials)
0 (Duffy Blood-Group System)
0 (Protozoan Proteins)
تواريخ الأحداث: Date Created: 20210527 Date Completed: 20210609 Latest Revision: 20240810
رمز التحديث: 20240812
مُعرف محوري في PubMed: PMC8154914
DOI: 10.1038/s41467-021-23422-3
PMID: 34039976
قاعدة البيانات: MEDLINE
الوصف
تدمد:2041-1723
DOI:10.1038/s41467-021-23422-3